Fragment-Based Drug Discovery: A Practical Approach / Edition 1

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Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery.
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Editorial Reviews

From the Publisher
"This is a useful book for readers already familiar with the basic aspects of drug design and discovery." (ChemMedChem, October 2009)

"This book provides an excellent resource for those in pharmaceutical research who are interested in fragment-based drug discovery. Most of the topics are covered in enough detail that this book could be used as a guide for those initiating a program in fragment-based drug discovery." (Journal of the American Chemical Society, April 29, 2009)

"As the authors eloquently state in Chapter 2, 'Where there is a validated target and a will, there is a (drug discovery) way.'" (Journal of Medicinal Chemistry, 2009)

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Product Details

  • ISBN-13: 9780470058138
  • Publisher: Wiley
  • Publication date: 12/31/2008
  • Edition number: 1
  • Pages: 296
  • Product dimensions: 6.80 (w) x 9.80 (h) x 0.90 (d)

Table of Contents

1 Introduction to Fragment-based Drug Discovery Mike Cherry Cherry, Mike Tim Mitchell Mitchell, Tim 1

2 Designing a Fragment Process to Fit Your Needs Edward R. Zartler Zartler, Edward R. Michael J. Shapiro Shapiro, Michael J. 15

3 Assembling a Fragment Library Mark Brewer Brewer, Mark Osamu Ichihara Ichihara, Osamu Christian Kirchhoff Kirchhoff, Christian Markus Schade Schade, Markus Mark Whittaker Whittaker, Mark 39

4 Practical Aspects of Using NMR in Fragment-based Screening Johan Schultz Schultz, Johan 63

5 Application of Protein-Ligand NOE Matching to the Rapid Evaluation of Fragment Binding Poses William J. Metzler Metzler, William J. Brian L. Claus Claus, Brian L. Patricia A. McDonnell McDonnell, Patricia A. Stephen R. Johnson Johnson, Stephen R. Valentina Goldfarb Goldfarb, Valentina Malcolm E. Davis Davis, Malcolm E. Luciano Mueller Mueller, Luciano Keith L. Constantine Constantine, Keith L. 99

6 Target-immobilized NMR Screening: Validation and Extension to Membrane Proteins Virginie Fruh Fruh, Virginie Robert J. Heetebrij Heetebrij, Robert J. Gregg Siegal Siegal, Gregg 135

7 In Situ Fragment-based Medicinal Chemistry: Screening by Mass Spectrometry Sally-Ann Poulsen Poulsen, Sally-Ann Gary H. Kruppa Kruppa, Gary H. 159

8 Computational Approaches to Fragment and Substructure Discovery and Evaluation Eelke van der Horst van der Horst, Eelke Adriaan P. IJzerman IJzerman, Adriaan P. 199

9 Virtual Fragment Scanning: Current Trends, Applications and Web-based Tools Bradley Feuston Feuston, Bradley M. Katharine Holloway Holloway, M. Katharine Georgia McGaughey McGaughey, Georgia J. Christopher Culberson Culberson, J. Christopher 223

10 Capture Methods forFragment-based Discovery Stig K. Hansen Hansen, Stig K. Daniel A. Erlanson Erlanson, Daniel A. 245

11 Identification of High-affinity [beta]-Secretase Inhibitors Using Fragment-based Lead Generation Jeffrey S. Albert Albert, Jeffrey S. Philip D. Edwards Edwards, Philip D. 261

Index 281

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