Frailty Syndrome: Basic and Clinical Aspects

by Maria Carmen Gómez Cabre (Editor), Jose Vina (Editor), Leocadio Rodríguez Mañas (Editor)

Overview

Frailty, a geriatric syndrome with a defined phenotype, which was introduced by Linda Fried and Jeremy Walston; it is widely cited. The importance of this syndrome cannot be overstated: Frailty has an enormous relevance in clinical settings, and there are clear biological bases behind its phenotype. This book covers both biological and clinical aspects, including interactions with diseases like diabetes.

Product Details

ISBN-13:	9781032503882
Publisher:	CRC Press
Publication date:	10/31/2025
Series:	Oxidative Stress and Disease
Pages:	272
Product dimensions:	7.00(w) x 10.00(h) x (d)

About the Author

José Viña  (ORCID 0000-0001-9709-0089) studied Medicine at the University of Valencia. He obtained his doctorate with Hans Krebs in Oxford, Professor of Physiology Valencia, and leads the FRESHAGE group that works on healthy aging, exercise and Alzheimer's disease. He has received two honorary doctorates from the Universities of Buenos Aires and Rennes. President of the International Society of Free Radicals (SFRR-I) Dr. Viña has been cited more than 21.000 times, resulting in an h-index of 79 (data taken from:  https://exaly.com/author/ 2255005/jose-vina/rankings)

 

Maria Carmen Gómez Cabrera ORCID: 0000-0003-4000-1684 is a full professor in the Department of Physiology at the Faculty of Medicine, University of Valencia. Her research focuses on the physiology of skeletal muscle and the mechanisms underlying muscle dysfunction, including the loss of strength and muscle mass associated with aging, periods of immobilisation or physical inactivity, and certain pathological conditions. Maria Carmen is the author of over 140 peer-reviewed international publications. Her contributions to exercise redox biology, healthy aging, frailty and sarcopenia have garnered over 14,000 citations, reflecting an h-index of 50.

 

Leocadio Rodríguez Mañas (ORCID: 0000-0002-6551-1333). Head of the Geriatrics Service of the Getafe University Hospital (Madrid) and Scientific Director of the Spanish Center for Biomedical Research on Frailty and Healthy Aging (CIBERFES) (Ministry of Science and Innovation and Ministry of Health). Coordinator of the Toledo Study of Healthy Aging. His research has been mainly focused on frailty and functional decline and diabetes in older people, the mechanisms involved, its operational definition (diagnostics tools) and its management (RCTs), including the use of the technology in the covering of the different requirements of the older frail people or at risk of frailty. He has participated in the preparation of technical reports on these topics for national and international organizations

Table of Contents

Chapter 01 Unveiling Vulnerability: Frailty in the Lens of Intrinsic Capacity

Chapter 02 Clinical management of frailty: Advances and Challenges

Chapter 03 Biomarkers of frailty

Chapter 04 Physical activity and exercise in the prevention and treatment of frailty

Chapter 05 Nutrition and Frailty: Epidemiological and Clinical Facts

Chapter 06 Physical functionbased programs in frailty

Chapter 07 Diabetes and frailtyinteractions and clinical implications

Chapter 08 Complexity and Disentanglement of Frailty: The biopsychosocial model of frailty and resilience

Chapter 09 The Impact of Polyphenol Intake on Cognitive Decline: Insights from Plasma and Urine Biomarker Analysis

Chapter 10 The role of the microbiota in aging and frailty

Chapter 11 Frailty in Experimental Animals: Models and Scores