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Francis Crick: Discoverer of the Genetic Code (Eminent Lives Series)

Overview

Francis Crick—the quiet genius who led a revolution in biology by discovering, quite literally, the secret of life—will be bracketed with Galileo, Darwin, and Einstein as one of the greatest scientists of all time. In his fascinating biography of the scientific pioneer who uncovered the genetic code—the digital cipher at the heart of heredity that distinguishes living from non-living things—acclaimed bestselling science writer Matt Ridley traces Crick's life from middle-class mediocrity in the English Midlands ...

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Francis Crick: Discoverer of the Genetic Code

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Overview

Francis Crick—the quiet genius who led a revolution in biology by discovering, quite literally, the secret of life—will be bracketed with Galileo, Darwin, and Einstein as one of the greatest scientists of all time. In his fascinating biography of the scientific pioneer who uncovered the genetic code—the digital cipher at the heart of heredity that distinguishes living from non-living things—acclaimed bestselling science writer Matt Ridley traces Crick's life from middle-class mediocrity in the English Midlands through a lackluster education and six years designing magnetic mines for the Royal Navy to his leap into biology at the age of thirty-one and its astonishing consequences. In the process, Ridley sheds a brilliant light on the man who forever changed our world and how we understand it.

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Editorial Reviews

From Barnes & Noble
Biographer Matt Ridley harbors no doubts that Francis Crick (1916-2004) belongs in HarperCollins's Eminent Lives series. Indeed, this award-winning science writer thinks that the "father of the genetic code" was a scientific innovator of the caliber of Einstein, Darwin, and Galileo. Ridley knew Crick, but his high estimate of the British physicist/molecular biologist/neuroscientist isn't based on friendship. Instead, the author of Genome argues that Crick's work in identifying the precise correspondence between specific DNA bases and the proteins they encode provided a truly epoch-making breakthrough. By delineating Crick's scientific work and sometimes difficult personality far beyond the now-familiar story of his initial Nobel Prize-winning double helix discovery, Ridley manages to flesh out one of the great names of modern science.
James D. Watson
“Matt Ridley’s Francis Crick perceptively and warmly recounts the extraordinary life of the 20th century’s most important biologist.”
Nicholas Wade
“Ridley has captured the wonder of an unparalleled scientific mind at work and at play.”
Kay Redfield Jamison
“Lucid and riveting . . . Completely captivating, a lively and deeply intriguing account of one of biology’s most imaginative scientists.”
Aaron Klug
“Matt Ridley’s book reads beautifully, the science flowing along with the life, to form a unity.”
David Quammen
“This is a wonderful book—deeply substantive, lucid, trenchant, and witty. It tells the biggest story in modern biology.”
Brenda Maddox
“Ridley captures Crick’s audacity, brilliance and, not least, eloquence…An excellent first biography”
Praise for Eminent Lives Series: FRANCIS CRICK and CHARLES DARWIN
Los Angeles Times Book Review
“A nimble biography.”
San Francisco Chronicle
“The reader gets a strong sense of how these men lived, what they achieved and how they achieved it.”
New York Times Book Review
“Thoughtful. . .aptly conjures a forgotten scientific landscape. . .”
BioScience
“Enjoyable…Ridley does an excellent job of escorting readers on [an] intellectual roller coaster ride.”
San Francisco Chronicle
“The reader gets a strong sense of how these men lived, what they achieved and how they achieved it.”
New York Times Book Review
“Thoughtful. . .aptly conjures a forgotten scientific landscape. . .”
Los Angeles Times Book Review
“A nimble biography.”
BioScience
“Enjoyable…Ridley does an excellent job of escorting readers on [an] intellectual roller coaster ride.”
Nicholas Wade
Mr. Ridley has created a vivid portrait that explains Crick’s scientific work with clarity, deftly outlines his career and provides sharp insights into the nature of Crick’s remarkable creativity.
— The New York Times
Publishers Weekly
Francis Crick (1916-2004) is a natural addition to the Eminent Lives series. Best known for his codiscovery of the structure of DNA alongside James Watson, Crick is a canonical figure in modern science; award-winning British science writer Ridley (The Agile Gene) is an expert and distinguished author of popular books on biological science. But one wishes the strictures of this series gave Ridley more space in which to work; the prose is crisp and forthright, but he barely has enough room to recount the basic contours of Crick's voracious scientific career, leaving the reader with but a few fleeting glimpses of the man's deeper character. Readers of Watson's The Double Helix who pick up this book looking for a similarly idiosyncratic portrait of a scientific life will be disappointed, but one might argue that this spare, straightforward volume is a more fitting tribute to a scientist who lived a relatively modest public life while striving to understand the basic workings of life and consciousness. (June 1) Copyright 2006 Reed Business Information.
Library Journal
An award-winning science writer adds to the "Eminent Lives" series. Copyright 2006 Reed Business Information.
Kirkus Reviews
Short biography of a giant in molecular biology. English science writer Ridley (Nature Via Nurture, 2003, etc.) posits that Francis Crick (1916-2004) was one of the greats, on par with Einstein, Darwin and Galileo. That claim may surprise those familiar with him primarily as James Watson's coauthor on the famous paper describing DNA's double helix. But the author, who knew Crick, argues that his work to establish the precise correspondence between specific DNA bases and the proteins they encode is a discovery as crucial as gravity or evolution. Ridley traces Crick's origins from a middle-class family of modest means. (His grandfather, an amateur naturalist, once exchanged letters with Darwin.) Trained as a physicist, Crick worked on defense projects involving mines and torpedoes during WWII and came out of the war with no clear direction. He decided to try biology, with a quixotic notion of finding the key to life. Landing a slot at Cambridge University's Cavendish Laboratory, he quickly established himself as a nonstop talker with an annoying laugh. Though a good theorist, he had problems with authority figures and was expected to leave once he finished his doctorate. Then Watson came to Cambridge; their joint assault on the structure of DNA is one of the best-known stories in modern science. Ridley covers the key details with keen insights into the pair's relationship, then moves on to Crick's role in solving the triplet code embedded in the DNA molecule. Nor does the text neglect his later work in both molecular biology and in attempting to solve the problem of consciousness. Crick comes across as a likable, highly motivated man without undue foibles; portraits of his coworkers and theperiod are also sharply drawn. A well-written addition to the publisher's "Eminent Lives" series.
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Product Details

  • ISBN-13: 9780061148453
  • Publisher: HarperCollins Publishers
  • Publication date: 11/3/2009
  • Series: Eminent Lives Series
  • Pages: 213
  • Sales rank: 1,410,262
  • Product dimensions: 5.20 (w) x 7.90 (h) x 0.60 (d)

Meet the Author

Matt Ridley is the author of several award-winning books, including Genome, The Agile Gene, and The Red Queen, which have sold more than 800,000 copies in twenty-seven languages worldwide. He lives in England.

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Read an Excerpt

Francis Crick

Discoverer of the Genetic Code
By Matt Ridley

HarperCollins Publishers, Inc.

Copyright © 2006 Matt Ridley
All right reserved.

ISBN: 006082333X

Chapter One

Crackers

Francis harry compton crick was born on 8 June 1916, at the height of World War I. The day before he was born, the news had broken that Lord Kitchener, Britain's celebrated minister of war, had been killed on board a cruiser bound for Russia. When Crick was a few weeks old, the first day of the battle of the Somme would claim 20,000 British lives. Far away from all this death, Crick was born at home in Holmfield Way in Northampton, a middle-class street in a middle-size town in the middle of the English Midlands. He was the son of a shoe manufacturer, Northampton being the shoemaking capital of Britain. Its streets were full of workshops and factories where leather-aproned workers still hammered and stitched soles, heels, and uppers. Shoemaking was an increasingly mechanised trade, thanks partly to the invention of one Thomas Crick of Leicester, who in 1853 took out a patent for an improved method of fixing uppers to soles with tacks or rivets instead of stitches. But, perhaps fortunately for posterity, Thomas Crick was no ancestor of Francis, who consequently was spared the distractions of great wealth.

Crick's Y chromosome had not wandered far in two centuries, or perhaps formuch longer. Crick is not an uncommon surname in the Midlands, the village of Crick in Northamptonshire being its probable origin. In 1861 Francis's great-grandfather Charles Crick was a fairly prosperous farmer, employing 20 men and boys on his 231 acres at Pindon End farm near the lace-making village of Hanslope just 10 miles south of Northampton. Charles's second son, Walter Drawbridge Crick, born in 1857, took a job as a clerk in the goods department of the London and Northwestern Railway, whose track bisected his father's farm. He soon switched to working as a travelling salesman for a shoemaker called Smeed and Warren. In 1880, when he was just 22 years old, he joined two others to start his own boot and shoe factory: Latimer, Crick, and Gunn, at Green Street, Northampton. (The churchyard at Hanslope has several Latimers buried in it, as well as some Cricks, so perhaps Latimer was a family friend.) The business thrived and expanded to Madras in India. At one time it also had five shops in London, and later it made military boots for those doomed young men at the Somme. By 1898 William Latimer and Thomas Gunn had retired, leaving Walter Crick the sole owner of the firm. He did well enough to build a substantial stone mansion, Nine Springs Villa, on Billing Road on the eastern side of Northampton. But five years later Walter Crick (at age 47) died of a heart attack, leaving the firm in the hands of his widow, Sarah -- who survived him by 31 years -- and two of his four sons, Walter and Harry, who carried on the business until it failed during the Depression.

The original Walter's enthusiasm for shoes, lucrative though it was, seems to have come second to his passion for science, and for collecting -- fossils, books, stamps, coins, porcelain, and furniture. His friends found him energetic and argumentative. Said one, in terms that might later have been applied to the grandson: "He was just as fond of springing a new and carefully stored fact into a discussion as he was of trumping a suit the first time round." He was an amateur naturalist of some local repute, who eventually wrote a two-part survey of the Liassic foraminifera of Northamptonshire and had two gastropods named after him. On foot and bicycle, he wandered the lanes of Northamptonshire collecting fossils and turning over rocks to look for snails. It was a tiny mollusc that caused Walter, grandfather of the greatest biologist of the twentieth century, to forge a brief link with the greatest biologist of the nineteenth: Charles Darwin.

It happened thus. On Saturday, 18 February 1882, Walter Crick was out hunting for water beetles (a curious occupation in winter, surely). We know this because later that day he wrote hesitantly to Darwin to report what he had found. "I secured a female Dytiscus marginalis," he told the great evolutionist, "with a small bivalve [cockle] that I think is Sphaerium corneum very firmly attached to its leg." Darwin replied three days later with a barrage of questions. He wanted to know the length and breadth of the shell, and how much of the leg (which leg?) had been caught; and he suggested a communication to the magazine Nature. To a young railway clerk turned shoemaker with (to judge by his handwriting) only a rudimentary education, this reply must have been a matter for some excitement. Crick replied with not only the answers, but also the beetle and the shell. Both arrived alive, so Darwin put the "wretched" insect in a bottle with chopped laurel leaves, "that it may die an easy and quicker death." He then sent both specimens off to an expert on shells for identification, but the expert was away and the specimens were returned, broken, by a servant. Meanwhile, Crick had returned to the same pond on a Sunday and found a dead frog with a cockle of the same kind attached to its foot. On 6 April, Darwin published a letter in Nature describing Crick's cockles, as a triumphant vindication of his long-held theory that peripatetic molluscs hitch lifts with other animals to get from pond to pond. It was to be Darwin's last publication: 13 days later, he died.

Walter and Sarah Crick had five children, born between 1886 and 1898. They were destined to grow to adulthood just as the relative peace and freedom of Edwardian England vanished, and they suffered their share of disappointments in the 30 years of war and slump that followed. The eldest, Walter, as senior director of the business, gets the family's blame for the failure of the shoe firm in the mid-1930s. One of the causes -- or consequences -- may have been his passionate interest in a . . .

Continues...


Excerpted from Francis Crick by Matt Ridley Copyright © 2006 by Matt Ridley. Excerpted by permission.
All rights reserved. No part of this excerpt may be reproduced or reprinted without permission in writing from the publisher.
Excerpts are provided by Dial-A-Book Inc. solely for the personal use of visitors to this web site.

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Table of Contents

Prologue: Life Itself 1

Chapter 1 Crackers 3

Chapter 2 Three Friends 17

Chapter 3 Cambridge 29

Chapter 4 Watson 45

Chapter 5 Triumph 59

Chapter 6 Codes 77

Chapter 7 Brenner 97

Chapter 8 Triplets and Chapels 115

Chapter 9 The Prize 127

Chapter 10 Never in a Modest Mood 145

Chapter 11 Outer Space 163

Chapter 12 California 179

Chapter 13 Consciousness 191

Epilogue: The Astonishing Hypothesisér 207

Sources and Acknowledgements 211

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Sort by: Showing all of 2 Customer Reviews
  • Posted January 9, 2010

    Francis Crick - A Tour de Force by Matt Ridley

    This book is a stunner. It describes in detail the life of Francis Crick, a giant in the field of molecular biology. It describes in detail the sequence of events and the technical achievements in Crick's life. It does so in a way that educates the reader about significant technical facts discovered by Crick that will materially assist the reader in learning how significant scientific discovery is done. One can only hope that Ridley will do other scientific biographies. The only contemporary of Ridley that readily comes to mind who approaches this level of achievement in scientific biography is James Gleich (Genius - The Life and Science of Richard Feynman, and other works). A must read for anyone doing serious science.

    1 out of 1 people found this review helpful.

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  • Anonymous

    Posted December 30, 2006

    Fun-ny

    I did not read this book, but I just had to comment on the title. I absolutely love how it portrays the story of the man who discovered DNA (without any help from James Watson or Rosalind Franklin)! The best take ever!

    Was this review helpful? Yes  No   Report this review
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