Francisella Tularensis: Biology, Pathogenicity, Epidemiology, and Biodefense / Edition 1

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This is the first book on tularemia. With the biodefense initiative, there has been a major boost by the NIH to fund studies on bioterrorism agents, including Francisella, which is classified as a A bioterrorism agent. With the major interest in biodefense and the major threats of bioterrorism, Francisella tularensis has become a major interest for microbiologists, cell biologists, immunologists, and infectious disease experts. The volume explores the mechanisms of pathogenesis, genetics and genetic manipulations, genomics and metagenomics, identification of vaccine candidates, animal models to study the disease process, mechanisms of protective immunity, pathophysiology, vaccine development, genetic susceptibility, more effective therapies, clinical diagnosis, and routine and rapid microbiological diagnostic tools.

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Product Details

Table of Contents


1. Tularemia: History, Epidemiology, Pathogen Physiology, andClinical Manifestations: Anders Sjostedt.

2. Molecular Ecology, Epidemiology and Evolution ofFrancisella: Paul Keim, Anders Johannson, and DavidWagner.

3. Genetics and Genetic Manipulations in FrancisellaTularensis: Tom Zahrt and Dara Frank.

4. Francisella Tularensis: Genomics and Proteomics:Richard Titball and Joseph Petrosino.

5. The Francisella Pathogenicity Island: Francis E. Nanoand Crystal Schmerk.

6. Molecular and Genetic Bases of Pathogenesis in FrancisellaTularensis: Jeffrey R. Barker and Karl E. Klose.

7. Uptake and Intracellular Fate of FrancisellaTularensis in Human Macrophages: Daniel Clemens and Marcus A.Horwitz.

8. Type II Secretion and Type IV Pili of Francisella:Tina Guina and Ake Forsberg.

9. The Structure and Function of Francisella LPS: JohnGunn and Robert Ernst.

10. Francisella Tularensis Activation of theInflammasome: David S. Weiss, Thomas Henry, and Denise M.Monack.

11. Animal Models of Francisella Tularensis Infection: C.Rick Lyons and Terry Wu.

12. Mucosal Immunopathogenesis of Francisella Tularensis:Dennis W. Metzger, Chandra Shekhar Bakshi, and GirishKirimanjeswara.

13. Innate and Adaptive Immunity to Francisella: Karen L.Elkins, Siobhán C. Cowley, and Catharine M. Bosio.

14. Vaccines against Francisella Tularensis: J. WayneConlan and Petra C.F. Oyston.

15. Pneumonic Tularemia on Martha's Vineyard: Clinical,Epidemiologic and Ecological Characteristics: Bela T. Matyas, HenryS. Nieder, Sam R. Telford III.

16. New Approaches to Diagnosis and Therapy of Tularemia: ArneTärnvik and May Chu.

17. Biosafety and Selectable Markers: Richard W. Titball, AndersSjostedt, Martin S. Pavelka Jr., and Francis Nano.

Index of Contributors

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