Free Radical Damage and its Control / Edition 1

Free Radical Damage and its Control / Edition 1

by C.A. Rice-Evans
     
 

ISBN-10: 044489716X

ISBN-13: 9780444897169

Pub. Date: 02/09/1994

Publisher: Elsevier Science

This book provides a comprehensive treatise on the chemical and biochemical consequences of damaging free radical reactions, the implications for the pathogenesis of disease and how this might be controlled endogenously and by radical scavenging drugs. Oxidative stress may be influenced by exogenous agents of oxidative stress, radiation, trauma, drug activation,

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Overview

This book provides a comprehensive treatise on the chemical and biochemical consequences of damaging free radical reactions, the implications for the pathogenesis of disease and how this might be controlled endogenously and by radical scavenging drugs. Oxidative stress may be influenced by exogenous agents of oxidative stress, radiation, trauma, drug activation, oxygen excess, or by exogenous oxidative stress which is associated with many pathological states including chronic inflammatory disorders, cardiovascular disease, injury to the central nervous system, and connective tissue damage. This and many other such aspects are presented clearly and in depth.

The development of antioxidant drugs depends on the understanding of the mechanisms underlying the generation of excessive free radicals in vivo, the factors controlling their release and the site of their action. This excellent volume presents an up-to-date account of the current state of knowledge in these areas.

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Product Details

ISBN-13:
9780444897169
Publisher:
Elsevier Science
Publication date:
02/09/1994
Series:
New Comprehensive Biochemistry Series, #28
Edition description:
New Edition
Pages:
412
Product dimensions:
1.00(w) x 6.14(h) x 9.21(d)

Table of Contents

Preface
List of contributors
Ch. 1Chemistry of iron and copper in radical reactions3
Ch. 2Some chemical and biochemical constraints of oxidative stress in living cells25
Ch. 3Ferryl iron and protein free radicals67
Ch. 4Antioxidants and free radical scavengers113
Ch. 5Formation of free radicals and mechanisms of action in normal biochemical processes and pathological states131
Ch. 6Free radicals and cell proliferation155
Ch. 7Therapeutic iron-chelating agents189
Ch. 8Free radicals in central nervous system injury217
Ch. 9Ultraviolet radiation (UVA, UVB) and skin antioxidants239
Ch. 10Free radicals and atherosclerosis257
Ch. 11Chemical aspects of free radical reactions in connective tissue281
Ch. 12Free radicals and connective tissue damage301
Ch. 13Free radicals in toxicology with an emphasis on electron spin resonance investigations319
Ch. 14Radical generation and detection in myocardial injury333
Ch. 15Free radical pathways in the inflammatory response361
Index385

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