Free Radicals and Oxidative Stress: Environment, Drugs and Food Additives

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Editorial Reviews

Booknews
The ramifications for biology and medicine of antioxidants, reactive oxygen species, and reactive nitrogen species, are the main theme of the 19 papers. They discuss the basic chemistry of free radicals, including nitric oxide; how the side-effects of certain drugs and air pollutants can be mediated by free radicals; the mechanisms of action of antioxidants in foods, both as dietary phytochemicals and in food preservation; the use of antioxidants in treatment of human disease; and other aspects. The collection begins with an outline of the paradox that aerobic organisms cannot survive without oxygen, which is inherently dangerous to their survival. Distributed in the US by Ashgate. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

Table of Contents

Preface
Abbreviations
Oxidative stress: the paradox of aerobic life 1
Nitric oxide and reactive oxygen species in vascular injury 33
Ultraviolet radiation and free radical damage to skin 47
Thiyl radicals in biological systems: significant or trivial? 55
The chemistry of lipid alkoxyl radicals and their role in metal-amplified lipid peroxidation 65
How to characterize an antioxidant: an update 73
Plant polyphenols: free radical scavengers or chain-breaking antioxidants? 103
Plant carotenoids and related molecules: important dietary antioxidants 117
Therapeutic iron chelators and their potential side-effects 127
Oxidative damage by ozone and nitrogen dioxide: synergistic toxicity in vivo but no evidence of synergistic oxidative damage in extracellular fluid 139
Biological and biochemical effects of air pollutants: synergistic effects of sulphite 153
Myeloperoxidase as a generator of drug free radicals 163
Radicals from one-electron reduction of nitro compounds, aromatic N-oxides and quinones; the kinetic basis for hypoxia-selective, bioreductive drugs 171
Side-effects of drugs used in the treatment of rheumatoid arthritis 195
Tamoxifen as an antioxidant and cardioprotectant 209
Antioxidant agents in raw materials and processed foods 221
Antioxidants in food packaging: a risk factor? 235
Free radicals and food irradiation 247
Atherogenic and anti-atherogenic factors in the human diet 259
Subject index 273
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