Free Radicals, Cardiovascular Dysfunction and Protection Strategies

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Editorial Reviews

From The Critics
Reviewer: Solomon Aronson, MD(University of Chicago Pritzker School of Medicine)
Description: This book is written as a thesis or grant proposal rather than as a textbook summary of myocardial reperfusion injury and therapeutic strategies.
Purpose: The authors state that their objective is to provide an overview of the role of free radicals in ischemia-reperfusion science; this intention is worthy and well timed. They fall short, however, of clearly synthesizing and presenting the data. The style of writing shifts back and forth without notice from that of a textbook delivering a constructive review and summary of established data to one that presents nonproven proposals and speculations.
Audience: Because the authors do not optimally reach either the clinician on one hand or the basic scientist on the other, this book is lacking a true target audience.
Features: The illustrations are all black-and-white, and most of them are simply reproductions of figures and tables from original manuscripts, rather than composites or summary tables. The book is not attractive.
Assessment: This book, as part of the Medical Intelligence Series, is written and organized to provide a current, however brief, overview of work in progress. The authors have devoted the latter chapters of the book to describe their own work in the field of ischemia-reperfusion science.
Solomon Aronson
This book is written as a thesis or grant proposal rather than as a textbook summary of myocardial reperfusion injury and therapeutic strategies. The authors state that their objective is to provide an overview of the role of free radicals in ischemia-reperfusion science; this intention is worthy and well timed. They fall short, however, of clearly synthesizing and presenting the data. The style of writing shifts back and forth without notice from that of a textbook delivering a constructive review and summary of established data to one that presents nonproven proposals and speculations. Because the authors do not optimally reach either the clinician on one hand or the basic scientist on the other, this book is lacking a true target audience. The illustrations are all black-and-white, and most of them are simply reproductions of figures and tables from original manuscripts, rather than composites or summary tables. The book is not attractive. This book, as part of the Medical Intelligence Series, is written and organized to provide a current, however brief, overview of work in progress. The authors have devoted the latter chapters of the book to describe their own work in the field of ischemia-reperfusion science.

2 Stars from Doody
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Product Details

Table of Contents

1 Introduction 1
2 Biochemistry of Oxygen and Nitrogen Metabolites 3
3 Mechanism of Oxygen Radicals Generation in Myocardium 9
4 Detection of Free Radicals During Ischemia-Reperfusion 19
5 Oxygen Radicals in Myocardial Injury 28
6 Myocardial Stunning 40
7 Nitric Oxide in Ischemia-Reperfusion 45
8 Myocardial Protection by Antioxidants 51
9 Histidine and Myocardial Protection 58
10 Ischemic Preconditioning 68
11 Heat Shock Proteins and Myocardial Protection 77
References 84
Index 109
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