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This latest edition has been comprehensively rewritten and updated (over 80% of the text is new), while maintaining the clarity of its predecessor. There is expanded coverage of isoprostanes and related compounds, mechanisms of oxidative damage to DNA and proteins (and the repair of such damage), the free radical theory of aging and the roles played by reactive species in signal transduction, cell death, human reproduction, and other important biological events. Greater emphasis has also been placed on the methods available to measure reactive species and oxidative damage (and their potential pitfalls), as well as the importance of antioxidants in the human diet.
This book is recommended as a comprehensive introduction to the field for students, clinicians and researchers, and an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.
Disc. oxygen toxicity, antioxidant defenses, oxi- dative stress, detection of free radicals, beneficial uses.
|List of abbreviations|
|1||Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive oxygen species||1|
|2||The chemistry of free radicals and related 'reactive species'||36|
|4||Oxidative stress: adaptation, damage, repair and death||246|
|5||Detection of free radicals and other reactive species: trapping and fingerprinting||351|
|6||Reactive species as useful biomolecules||430|
|7||Oxidative stress and antioxidant protection: some special cases||485|
|8||Free radicals, 'reactive species' and toxicology||544|
|9||Free radicals, other reactive species and disease||617|
|10||Ageing, nutrition, disease and therapy: a role for antioxidants?||784|
|App. I||Some basic chemistry for the life scientist||860|
|App. II||Some basic molecular biology for the chemist||880|