Free Radicals in Biology and Medicine / Edition 4

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Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing.

This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.

Disc. oxygen toxicity, antioxidant defenses, oxi- dative stress, detection of free radicals, beneficial uses.

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Editorial Reviews

Doody's Review Service
Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: This book comprehensively covers free radical biology. The prior edition was published eight years ago and new material justifies the new edition.
Purpose: The goal is to offer a full treatment of free radicals in the biological setting. Given their widespread importance, this is a worthy aim and the book is generally successful.
Audience: The intended audience, according to the authors, is the biologist or clinician with an interest in the area, but I would broaden the audience that would find this material of interest. The authors have long experience in the field and are well qualified.
Features: There is much misinformation available about free radicals and their various roles in biology. If one doubts this, review the contents of the dietary supplement shelf at your local supermarket. This fourth edition provides the reader with a comprehensive review of the field. The book is arranged in a logical fashion that indirectly also caters to the relatively naive reader. Initial chapters cover basic chemistry and defense mechanism (including dietary concerns). This section is followed by chapters on cellular responses and measurement of the various members of the oxygen radical family. Concluding chapters cover useful and destructive roles for oxygen radicals, their involvement in disease states, and an ending chapter reviews theories related to aging. A short appendix introduces the reader to the basics of chemistry. The extensive bibliography is grouped at the end but is divided by chapter so that key references remain readily accessible. The authors deserve credit for their generally lucid presentation, especially of complex material. Anyone interested in free radicals generally, and reactive oxygen species in particular, will find much of value here. Senior scientists working in the area will also encounter useful peripheral material.
Assessment: This is a comprehensive and informative volume. Even casual reading unearths useful information.
Halliwell (medical biochemistry, King's College, London) and Gutteridge (pharmacology, King's College) direct their discussion primarily to biologists and clinicians, and assume virtually no knowledge of chemistry. Their goal is to lead readers gently into an understanding of what free radicals are, how they are generated, and how they can react. Then they evaluate the role of radical reactions in several biological systems. The first edition appeared in 1985, and the 1989 second edition is here updated with the extensive information provided by modern techniques of molecular, cellular, and structural biology. They also cite at least one reference for each finding. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780198568698
  • Publisher: Oxford University Press
  • Publication date: 5/10/2007
  • Edition description: REV
  • Edition number: 4
  • Pages: 704
  • Product dimensions: 9.70 (w) x 7.40 (h) x 1.70 (d)

Meet the Author

Barry Halliwell, Executive Director, Graduate School for Integrative Sciences and Engineering, National University of Singapore,John M. C. Gutteridge

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Table of Contents

List of abbreviations
1 Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive oxygen species 1
2 The chemistry of free radicals and related 'reactive species' 36
3 Antioxidant defences 105
4 Oxidative stress: adaptation, damage, repair and death 246
5 Detection of free radicals and other reactive species: trapping and fingerprinting 351
6 Reactive species as useful biomolecules 430
7 Oxidative stress and antioxidant protection: some special cases 485
8 Free radicals, 'reactive species' and toxicology 544
9 Free radicals, other reactive species and disease 617
10 Ageing, nutrition, disease and therapy: a role for antioxidants? 784
App. I Some basic chemistry for the life scientist 860
App. II Some basic molecular biology for the chemist 880
Index 899
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