From Molecules to Networks: An Introduction to Cellular and Molecular Neuroscience / Edition 2

Hardcover (Print)
Rent from
(Save 69%)
Est. Return Date: 12/01/2014
Buy New
Buy New from
Buy Used
Buy Used from
(Save 37%)
Item is in good condition but packaging may have signs of shelf wear/aging or torn packaging.
Condition: Used – Good details
Used and New from Other Sellers
Used and New from Other Sellers
from $40.78
Usually ships in 1-2 business days
(Save 58%)
Other sellers (Hardcover)
  • All (11) from $40.78   
  • New (3) from $83.87   
  • Used (8) from $40.78   


An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphologic, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this 2e to reflect the significant advances of the past 5 years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease.

• Written and edited by leading experts in the field, the second edition completely and comprehensively updates all chapters of this unique textbook

• Discusses emerging new understanding of non-classical molecules that affect neuronal signaling

• Full colour, professional graphics throughout

• Includes two new chapters: Information Processing in Neural Networks - describes the principles of operation of neural networks and the key circuit motifs that are common to many networks in the nervous system. Molecular and Cellular Mechanisms of Neurodegenerative Disease - introduces the progress made in the last 20 years in elucidating the cellular and molecular mechanisms underlying brain disorders, including Amyotrophic Lateral Sclerosis (ALS), Parkinson disease, and Alzheimer’s disease.

• Companion website for students provides quizzes to aidtheircomprehension of this material. Manual site for instructors providesfigures in Powerpointandsolutions to quizzes.

Audience: Researchers in neuroscience and neurology as well as graduate students in neuroscience and medical students.

Read More Show Less

Editorial Reviews

From the Publisher
“John H. Byrne and James L. Roberts, who treated us to a superb textbook in their first edition of From Molecules to Networks, have now returned with another outstanding effort in the second edition. They have not only updated their comprehensive book but added to it important new sections on the molecular biology of neurological disorders and on the logic of informational processing by neural networks, the two key themes emerging in modern neuroscience. This book will be welcomed by students and experienced scientists alike as a coherent and valuable resource on cellular and molecular neuroscience.” —Eric R. Kandel, Howard Hughes Medical Institute; Columbia University College of Physicians and Surgeons, New York, USA

“The world of neuroscience is extraordinarily broad and complex, ranging from molecular biology through neurotransmission to neuronal networks and brain disease. How can one convey to the student and professional coherently the ‘big picture’ without sacrificing critical detail? In the second edition of their now classic volume, John Byrne and James Roberts accomplish this task with rigor, elegance and, remarkable lucidity…The volume will be indispensable both for student and advanced researcher …” —Solomon H Snyder, Distinguished Service Professor of Neuroscience, Pharmacology and Psychiatry, Johns Hopkins University, Baltimore, USA

“The development of systems biology across all of biological sciences has underlined the need for a neuroscience book whose goal is to span the range from molecular mechanisms to the neural substrate of behavior. The first edition of Byrne and Roberts was ahead of its time in doing what has now become the fashion. That was a wonderful book, and the second edition is even better. A ‘must have’.” —Charles F. Stevens, Professor and Vincent J. Coates Chair in Molecular Neurobiology, The Salk Institute for Biological Studies, San Diego, USA

“This second edition brings up to date a superb neuroscience book, further enhancing its unique original strength—elegance thoroughness, and clarity, contextually presented.” —Rodolfo Llinas, Thomas and Susanne Murphy Professor of Neuroscience and Chairman, New York University Langone Medical Center, New York, USA

From The Critics
Reviewer: Celso Agner, MD, MS, MSc(University of Illinois at Chicago College of Medicine)
Description: The field of neuroscience has been one of the most progressive over the past few decades. The introduction of molecular biology allowed for the description of new classes of membrane proteins and, in particular, signal receptors in the nervous system. A review of this fascinating and rapid-paced field is necessary for anyone who studies the central nervous system.
Purpose: The field of neuroscience has been one of the most progressive over the past few decades. The introduction of molecular biology allowed for the description of new classes of membrane proteins and, in particular, signal receptors in the nervous system. A review of this fascinating and rapid-paced field is necessary for anyone who studies the central nervous system.
Audience: Graduate and postgraduate students and neurologists/neurosurgeons interested in the field of neuroscience are the primary audiences for this book. The authors are credible authorities from recognized institutions in the U.S. and Europe and have all extensively published in the topics they write about.
Features: The 39 authors contribute 18 chapters. The book starts off by addressing the basic neuroscience, progressing to the molecular biology of each of the structures and behaviors described and finishing with a comprehensive description of behaviors and memory. At first glimpse, it seems just like any other book in neuroscience. However, each chapter is accompanied by mathematical models to reproduce the behaviors described. In addition, a CD with all the illustrations is included, which is a very helpful tool for graduate students, who frequently need to present their data in conferences and inside their departments. The book is affordable for graduate students which, in my view, is an important aspect to consider.
Assessment: Overall, this is an affordable good book for graduate, postgraduate, and professionals such as neurologists and neurosurgeons. It is a great buy for general and neuroscience libraries.

3 Stars from Doody
Read More Show Less

Product Details

  • ISBN-13: 9780123741325
  • Publisher: Elsevier Science
  • Publication date: 1/23/2009
  • Edition description: Older Edition
  • Edition number: 2
  • Pages: 656
  • Sales rank: 985,859
  • Product dimensions: 8.70 (w) x 11.00 (h) x 1.40 (d)

Meet the Author

Professor, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Heidelberger is an accomplished cellular neurophysiologist specializing in mechanisms of neurotransmitter release. She received her doctoral training under the guidance of Gary Matthews and her postdoctoral training under the direction of Nobel Laureate Erwin Neher. Dr. Heidelberger is a former president and executive board member of the Biophysical Society's Subgroup on Exocytosis and Endocytosis and serves on the editorial board of the Journal of Neurophysiology. She has directed and taught graduate-level courses in cellular neurophysiology and membrane biophysics for more than a decade.

The William Wheless III Professor, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Waxham’s multi-disciplinary laboratory focuses on the molecular and cellular mechanisms of synaptic function and plasticity. He has developed and directed graduate-level courses in cellular and molecular neurobiology for more than two decades.

The June and Virgil Waggoner Professor and Chair, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Byrne is an internationally acclaimed Neuroscientist. He received his PhD under the direction of Noble Prize winner, Eric Kandel. Dr. Byrne is a prolific author and Editor-in-Chief of Learning and Memory (CSHP).

Read More Show Less

Read an Excerpt

A comprehensive textbook on cellular and molecular neuroscience intended for advanced undergraduate, graduate, and medical students.
Read More Show Less

Table of Contents

1. Cellular Components of Nervous Tissue
Patrick R. Hof, Esther A. Nimchinsky, Grahame Kidd, Luz Claudio, and Bruce D. Trapp
2. Subcellular Organization of the Nervous System: Organelles and Their Functions
Scott Brady, David R. Colman, and Peter Brophy
3. Energy Metabolism in the Brain
Gerald A. Dienel
4. Electronic Properties of Axons and Dendrites
John H. Byrne and Gordon M. Shepherd
5. Membrane Potential and Action Potential
David A. McCormick
6. Molecular Properties of Ion Channels
David Matthew Young, Yuh Nung Jan, and Lily Yeh Jan
7. Dynamical Properties of Excitable Membranes
Douglas A. Baxter and John H. Byrne
8. Release of Neurotransmitters
Robert S. Zucker, Dimitri M. Kullmann, and Thomas L. Schwarz
9. Pharmacology and Biochemistry of Synaptic Transmission: Classic Transmitters
Ariel Y. Deutch and Robert H. Roth
10. Peptides, Growth Factors, Gasses and Other Neurotransmitters
Ariel Y. Deutch, Andrea Giuffrida and James L. Roberts
11. Neurotransmitter Receptors
M. Neal Waxham
12. Intracellular Signalling
Howard Schulman
13. Regulation of Neuronal Gene Expression and Protein Synthesis
James L. Roberts and James R. Lundblad
14. Mathematical Modeling and Analysis of Intracellular Signaling Pathways
Paul D. Smolen, Douglas A. Baxter, and John H. Byrne
15. Connexin- and Pannexin-Based Channels in the Nervous System: Gap Junctions and More
Juan C. Sáez and Bruce J. Nicholson
16. Postsynaptic Potentials and Synaptic Integration
John H. Byrne
17. Complex Information Processing in Dendrites
John H. Byrne and Gordon M. Shepherd
18. Information Processing in Neural Networks
James J. Knierim
19. Learning and Memory: Basic Mechanisms
John H. Byrne, Kevin S. LeBar, Joseph E. LeDoux, Glenn E. Schafe, Richard F. Thompson, and J. David Sweatt
20. Molecular and Cellular Mechanisms of Neurodegenerative Disease
Mark R. Cookson, Randy Strong, P. John Hart, and James L. Roberts
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)