Frontiers in Brain Repair / Edition 1

Frontiers in Brain Repair / Edition 1

by Rahul Jandial
     
 

ISBN-10: 1441958185

ISBN-13: 9781441958181

Pub. Date: 04/01/2010

Publisher: Springer New York

* Provide a representative survey of the current science of brain repair - Provids the reader with a broad introduction into molecular imaging, stem cell biology, cell therapy, animal models, central nervous system malignancies, stroke, and neurodegeneration In the rapidly-evolving landscape of neurosciences, it is no easy task to select a limited array of topics

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Overview

* Provide a representative survey of the current science of brain repair - Provids the reader with a broad introduction into molecular imaging, stem cell biology, cell therapy, animal models, central nervous system malignancies, stroke, and neurodegeneration In the rapidly-evolving landscape of neurosciences, it is no easy task to select a limited array of topics to present in a text such as this. The current volume takes as its purpose to provide a representative survey of the current science of brain repair for those seeking to establish a foundation in the field or to replenish a prior knowledge base that may have lapsed in its currency. It also hopes to offer insights into what remains elusive to our collective investigations, defining the "frontiers" of brain repair for those that are currently immersed in the exciting intersection of biological advances and neuroscientific discoveries. In Chapter 1 the fundamentals of imaging transplanted cells is discussed with emphasis on animal models as well as the horizon for clinical trials. Then, detailed methods on the culture of neural stem cells is reviewed as a foundation for approaching therapeutic goals. Chapter 3 presents the broad scope of animal models that serve as the foundation for developmental and pre-clinical investigation, with mention of recent genetically engineered mouse models that represent the best models for studying disease development and treatment. Chapter 4 provides background on the delivery techniques to animals and patients that are available, providing vital information on the subtleties of technique necessary for optimal cellular grafting. Chapters 5 and 6 discuss new and evolving information on the origins of brain tumors and the indelible role of stromal and microenvironmental influences on oncogenesis and tumor progression. Subsequently, the utility of neural stem cells as cellular vehicles to deliver chemotherapeutics to broad neuropathology is revie

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Product Details

ISBN-13:
9781441958181
Publisher:
Springer New York
Publication date:
04/01/2010
Series:
Advances in Experimental Medicine and Biology Series, #671
Edition description:
2010
Pages:
134
Product dimensions:
6.70(w) x 10.20(h) x 0.50(d)

Table of Contents

In Vivo Imaging of Cellular Transplants.- Culture and Manipulation of Neural Stem Cells.- Animal Models of Neurological Disease.- Stem Cell Transplantation Methods.- Stem Cell Origin of Brain Tumors.- The Tumor Microenvironment.- Exploitation of Genetically Modified Neural Stem Cells for Neurological Disease.- Biological Horizons for Targeting Brain Malignancy.- Stem Cells in the Treatment of Stroke.- Gene- and Cell-Based Approaches for Neurodegenerative Disease.

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