Frontiers in Cerebrovascular Disease: Mechanisms, Diagnosis, and Treatment

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Armonk, New York, U.S.A. 1997 Hardcover New 0879936746. FLAWLESS COPY, AVOID WEEKS OF DELAY ELSEWHERE. --clean and crisp, tight and bright pages, with no writing or markings to ... the text. -- Read more Show Less

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Overview

With stroke now being considered as a "brain attack", this timely collection presents an excellent selection of the leading-edge research and therapy necessary for a more aggressive understanding and approach to stroke patients.

The text focuses on such key topics as:


  • Vascular factors in thrombosis
  • Advances in neuroimaging
  • Pathways of ischemic cell death
  • Protective and restorative mechanisms
  • Emerging therapy of ischematic stroke
  • Mechanisms of ischemic brain injury

Combining the experiences, research and speculation of basic scientists and clinicians, this reference does much more than serve as a mere update - it is guaranteed to challenge and enrich your own thinking on the topic.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Cathy M. Helgason, MD (University of Illinois at Chicago College of Medicine)
Description: This book contains the proceedings of the 20th Princeton Conference on Cerebrovascular Disease held in Memphis in March, 1996.
Purpose: The purpose is to enshrine the proceedings for posterity, a worthy goal. The book focuses on research and therapy of cerebrovascular disease and is a compilation of presentation-based papers on thrombosis, advances in neuroimaging, pathways of cell death, protective and restorative mechanisms, and therapy for stroke and brain ischemic injury.
Audience: The book is intended for all whose interest is in current advances in research of cerebrovascular disease.
Features: Unique to this book is the combined presentation of clinical and basic science research issues. It is judiciously illustrated and the references are current and pertinent. The size of the book is such that it can be read easily at a desk top or in a comfortable arm chair.
Assessment: This is an excellent addition to any library shelf on stroke; in fact, such a shelf would be incomplete without it.
Cathy M. Helgason
This book contains the proceedings of the 20th Princeton Conference on Cerebrovascular Disease held in Memphis in March, 1996. The purpose is to enshrine the proceedings for posterity, a worthy goal. The book focuses on research and therapy of cerebrovascular disease and is a compilation of presentation-based papers on thrombosis, advances in neuroimaging, pathways of cell death, protective and restorative mechanisms, and therapy for stroke and brain ischemic injury. The book is intended for all whose interest is in current advances in research of cerebrovascular disease. Unique to this book is the combined presentation of clinical and basic science research issues. It is judiciously illustrated and the references are current and pertinent. The size of the book is such that it can be read easily at a desk top or in a comfortable arm chair. This is an excellent addition to any library shelf on stroke; in fact, such a shelf would be incomplete without it.
Booknews
Chapters based on presentations made at the 20th Princeton Conference on Cerebrovascular Disease held in March, 1996 in Memphis, Tennessee present current efforts in research and therapy. Contributors focus on vascular factors in thrombosis, advances in neuroimaging, pathways of ischemic cell death, protective and restorative mechanisms, emerging therapy of ischemic stroke, and the frontiers and mechanisms of ischemic brain injury. Annotation c. by Book News, Inc., Portland, Or.

5 Stars! from Doody
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Product Details

Table of Contents

Contributors
Preface
Pt. 1 Vascular Factors in Thrombosis
Ch. 1 Cerebral Vascular Effects of Atherosclerosis and Homocysteine: Potential Target for Gene Therapy 3
Ch. 2 Current Trends in the Development of Antithrombotic Agents 15
Ch. 3 Shear Stress in Thrombosis and Atherosclerosis 39
Pt. 2 Advances in Neuroimaging, Utilization, Therapeutic Decision Making, Adhesion Molecules, and Other Factors Contributing to Microvascular Occlusion
Ch. 4 An Assessment of Human Ischemic Stroke by MRI Generated Signatures of Histopathology 51
Ch. 5 The Role of Adhesion Molecules in Acute Cerebral Ischemia 63
Ch. 6 Blood-Brain Barrier and Endothelial Damage in Cerebral Ischemia 85
Ch. 7 Secondary Ischemic Neuronal Damage May Involve Multiple Factors Acting as an Aggregate of Minor Causes 95
Ch. 8 Modulatory Sites of NMDA Receptors and Regulation of Long-Term Consequences of Ischemia 103
Ch. 9 Cerebral Ischemia and Reperfusion Injury in Mitochondrial Manganese Superoxide Dismutase-Deficient Mice: Role of Superoxide Radicals 121
Pt. 3 Pathways of Ischemic Cell Death
Ch. 10 Glutamate Receptors: From In Vitro Studies to Mouse Models 135
Ch. 11 Cell Signaling Following Ischemia 139
Ch. 12 Nitric Oxide Neurotoxicity in Models of Ischemic Damage 149
Ch. 13 Morphological Comparisons Between Apoptosis and Necrosis in Postischemic Neuronal Death 167
Ch. 14 An Epidemic of Vascular Cognitive Impairment? 179
Pt. 4 Protective and Restorative Mechanisms
Ch. 15 Cellular Actions of Tumor Necrosis Factor and Secreted Amyloid Precursor Protein in Ischemic Brain Injury 189
Ch. 16 Cytoskeletal Proteins in Neuronal Development 211
Ch. 17 Neuronal Death and Subsequent Synaptic Reorganization: Hypothetical Mechanism for Lesion-Induced Epilepsy 217
Ch. 18 Intracerebral Hemorrhage as a Complication of Thrombolytic Therapy 235
Comments on Intracranial Hemorrhage in Thrombolytic Therapy of Acute Ischemic Stroke 245
Ch. 19 Baseline CT and Effects of Time to Treatment on Hemorrhages, Mortality, and Clinical Outcome in ECASS: Post Hoc Analysis 249
Pt. 5 Frontiers in Mechanisms of Ischemic Brain Injury
Ch. 20 Mechanisms of Ischemic Brain Damage: The Mitochondrial Hypothesis Revisited 261
Ch. 21 Zinc and Selective Neuronal Death 275
Ch. 22 Cellular Mechanisms of Neuronal Protection by Metabolic Glutamate Receptors 281
Ch. 23 Postischemic Gene Expression and Ischemic Brain Damage: Role of Inducible Nitric Oxide Synthase 299
Ch. 24 Peroxynitrite as a Mediator of Injury in Brain Ischemia, Atherosclerosis, and Amyotrophic Lateral Sclerosis 315
Ch. 25 DNA Fragmentation in Focal Brain Ischemia 339
Index 347
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