Function and Regulation of Cellular Systems / Edition 1

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Current biological research demands the extensive use of sophisticated mathematical methods and computer-aided analysis of experiments and data. This highly interdisciplinary volume focuses on structural, dynamical and functional aspects of cellular systems and presents corresponding experiments and mathematical models.
The book may serve as an introduction for biologists, mathematicians and physicists to key questions in cellular systems which can be studied with mathematical models. Recent model approaches are presented with applications in cellular metabolism, intra- and intercellular signaling, cellular mechanics, network dynamics and pattern formation. In addition, applied issues such as tumor cell growth, dynamics of the immune system and biotechnology are included.

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Product Details

Table of Contents


Part I Metabolic Networks and Engineering

Introduction to Part I
Reinhart Heinrich, Thomas Höfer

A Functional Dynamics Approach to Modelling of Glycolysis
Hynne Finn, Sune Dano, Preben G. Sørensen

Temperature-Compensation in Biological Clocks: Models and Experiments
Peter Ruoff

Metabolic Control Analysis of the ATPase Network in Contracting Muscle:
Regulation of Contractile Function and ATP Free Energy Potential

Jeroen A.L. Jeneson, Hans V. Westerhoff, Martin J. Kushmerick

En Route for Systems Biology: In Silico Pathway Analysis and Metabolite
Jochen Förster, Mats Åkesson Jens Nielsen

Part II Intracellular Signal Transduction

Introduction to Part II
Thomas Höfer, Reinhart Heinrich

Presynaptic Calcium Dynamics of Neurons in Answer to Various Stimulation
Michael Meyer-Hermann, Frido Erler, Gerhard Soff

Mathematical Modeling of Signaling Cascades: Principles and Future
Birgit Schöberl, Martin Ginkel, Ernst Dieter Gilles, Gertrud Müller

Collective Behavior of Membrane Channels: Electro-physiological Studies on Gap Junctions
Paramita Ghosh, Debasish Bose, Subhendu Ghosh

Modelling of Periodic Intercellular Ca2+ Waves
Antonio Politi, Thomas Höfer

Travelling Waves as a Mechanism of Pattern Generation in Discrete Cell
Erik Plahte, Leiv Øyehaug

Design and Operation: Keys to Understanding Biological Systems
Eberhard O. Voit

Part III Cellular Materials: Mechanics and Motility

Introduction to Part III
Erwin Frey, Wolfgang Alt

Biopolymer Dynamics
Chris Wiggins, Loïc Le Goff

Micromechanics of Molecular Motors: Experiments and Theory
Andrea Parmeggiani, Christoph F. Schmidt

The Role of Osteocalcin in the Remodeling of Biomimetic
Hydroxyapatite-Collagen Materials for Bone Replacement
Wolfgang Pompe, K... Flade, Michael Gelinsky, B ... Knepper-Nicolai, A
... Reinstorf

Cell Shape Normalization of Normal and Haploinsufficient NF1-Melanocytes by Micro-Structured Substrate Interaction
Ralf Kemkemer, Hans Gruler, Dieter Kaufmann, Joachim Spatz

Quantification of Shear Stress-Induced Cell Migration in Endothelial
Peter Dieterich, Jochen Seebach, Hans-J. Schnittler

Part IV Complex Network Dynamics in Biological Cells

Introduction to Part IV
Alexander S. Mikhailov

Constructive and Dynamical Systems Approach to Life
Kunihiko Kaneko

Coherent Dynamics in Networks of Single Protein Molecules
Hans-Philipp Lerch, Pedro Stange, Benno Hess

Gene Regulatory Networks: A Discrete Model of Dynamics and Topological
Thimo Rohlf, Stefan Bornholdt

Evolutionary Reconstruction of Networks
Mads Ipsen

Modelling Simple Biochemical Networks
Rengaswamy Maithreye, Somdatta Sinha

On the Evolution of Information in the Constituents of Regulatory Gene
Jan T. Kim, Thomas Martinetz, Daniel Polani

Part V Interacting Cell Systems

Introduction to Part V
Dirk Drasdo, A ... Stevens

Biological Relevance of Tissue Liquidity and Viscoelasticity
Gabor Forgacs

Reinforcement of Cytoskeleton-Matrix Bonds and Tensiotaxis: A Cell-Based
Till Bretschneider

Simulation of Haematopoietic Stem Cell Organisation Using a Single Cell
Based Model Approach
Ingo Röder, Markus Löffler

Pattern Formation in an Interacting Cell System: Rippling in
Myxobacterial Aggregates
Uwe Börner, Andreas Deutsch, Markus Bär

Part VI How Cells Construct an Organism: Experiments and Modelling

Introduction to Part VI
Markus Kirkilionis

Molecular and Cellular Analysis of the Novo Pattern Formation in Hydra
Ulrich Technau, Bert Hobmayer, Fabian Rentzsch, Thomas W. Holstein

The Small Freshwater Polyp Hydra as a Model for Axis Formation in Higher
Hans Meinhardt

Cell Migration, Cell Fate and Pattern Formation During Head Development in Lungfishes and Amphibians
Lennart Olsson

How Cells Construct an Organism: The Directions of Theoretical Research
Markus Kirkilionis

Part VII Tumors, Diseases and the Immune System

Introduction to Part VII
M ... Or-Guil, A... Stevens, Dirk Drasdo

Cell-Based Models of Avascular Tumor Growth
Dirk Drasdo, Sabine Dormann, Stefan Höhme, Andreas Deutsch

Solid Tumor Invasion: The Importance of Cell Adhesion
Alexander R.A. Anderson

Interrelationship of Tumour and Immune System
Peter Walden

Nonlinear Dynamics and Statistical Physics of Models for the Immune
Ulrich Behn, Markus Brede, Jan Richter

Shastic Model of Influenza Virus Fusion
Susanne Schreiber, Kai Ludwig, Hermann-Georg Holzhütter, Andreas

Spatio-Temporal Aspects of a Dynamical Disease: Waves of Spreading
Markus A. Dahlem, Thomas Mair, Stefan C. Müller

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