Functional Imaging in the Epilepsies

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Addresses all aspects of functional imaging in diagnosis and management of epilepsy, describing the latest tools and techniques and discussing their roles and limitations. Chapters are arranged in sections on single-photon emission computed tomography in the epilepsies, positron emission tomography, nuclear magnetic resonance imaging, and integrated functional neuroimaging applications. Although the output of most techniques covered is brain images, this work emphasizes that primary data sets contain a wealth of information that increasingly sophisticated analysis techniques are beginning to unveil. Includes summary chapters. Material originated at the fall 1998 International Symposium of Functional Neuroimaging in the Epilepsies. Henry teaches neurology at Emory University. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780781722667
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 7/28/2000
  • Series: Advances in Neurology Series
  • Edition number: 1
  • Pages: 352

Table of Contents

Contributing Authors
1 Overview of Functional Neuroimaging in Epilepsy 1
2 SPECT: Methodology 11
3 SPECT: Neurobiology of Periictal Blood Flow Alterations 33
4 SPECT: Ictal Perfusion in Localization-related Epilepsies 41
5 SPECT: Ictal Perfusion in Childhood Epilepsies 51
6 Radiotracers and Analytical Approaches in Positron and Single-Photon Emission Tomography 61
7 PET Image Acquisition and Analysis 69
8 PET: Activation of Cerebral Blood Flow and Glucose Metabolism 87
9 PET: Cerebral Blood Flow and Glucose Metabolism - Presurgical Localization 105
10 PET: Cerebral Blood Flow and Glucose Metabolism - Pathophysiology and Drug Effects 121
11 PET: Central Benzodiazepine Neuroreceptor Mapping in Localization-related Epilepsies 131
12 PET: Central Benzodiazepine Neuroreceptor Mapping in Generalized Epilepsies 137
13 PET: Opiate Neuroreceptor Mapping 145
14 PET: Cholinergic Neuroreceptor Mapping 157
15 PET: Mapping of Serotonin Synthesis 165
16 Imaging Monoamine Oxidase B Receptor Mapping 173
17 fMRI: Methodology - Acquisition and Processing 177
18 Methodology: EEG-correlated fMRI 187
19 Ictal fMRI: Methods and Models 203
20 fMRI: Methodology - Sensorimotor Function Mapping 213
21 fMRI: Methodology - Cognitive Function Mapping 221
22 MRS Methodology 235
23 Proton MRS: Lactate 247
24 Proton MRS: N-Acetyl Aspartate, Creatine, and Choline 253
25 Proton MRS: GABA and Glutamate 261
26 Phosphorus MRS: pH, ATP, PCr 273
27 Diffusion-weighted MRI: Periictal Studies 279
28 Functional Neuroimaging in Localization of the Ictal Onset Zone 285
29 Functional Neuroimaging in Presurgical Localization of Essential Cortical Processing Zones 297
30 Functional Imaging Studies of Epilepsy Therapies 305
Subject Index 319
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