Functional Neuroimaging in Clinical Populations

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Bringing together leading experts, this volume reviews cutting-edge applications of neuroimaging techniques in the study of brain injury, brain disease, and normal aging. It provides up-to-date descriptions of EEG, MEG, PET and fMRI; discusses salient methodological issues; presents significant clinical advances that have been brought about through the use of these procedures. Specific disorders addressed include epilepsy, aphasia, traumatic brain injury, multiple sclerosis, alcoholism, autism, schizophrenia, and stroke. Analyzing what functional imaging has revealed about the causes and mechanisms of sensory, motor, and cognitive disturbances associated with these conditions, the book also explores implications for cognitive rehabilitation. More than 60 illustrations, including 24 in full color.

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Editorial Reviews

Doody's Review Service
Reviewer: Michael Joel Schrift, DO, MA (University of Illinois at Chicago College of Medicine)
Description: The clinical-pathological correlation was essential in placing medicine on a scientific basis over 100 years ago. Unfortunately for psychiatry and much of neurology, the study of brain-behavior relationships was limited, prior to the last two decades, to patients with focal brain lesions. But lesions are not synonymous with function. The advent of functional brain imaging has catalyzed a revolution and paradigm shift in the understanding of brain-behavior relationships and has given rise to the field of cognitive neuroscience. Thus the cognitive and behavioral consequences of focal brain lesions such as aphasia and the brain activations that occur when a normal individual performs language-related tasks that engage specific brain regions complement one another and provide a much richer understanding of the brain and its mechanisms. This book, written and edited by nationally recognized cognitive neuroscientists, is an outstanding review of the literature on functional imaging in neuropsychiatric disorders and is a welcome contribution to the field.
Purpose: The purpose is to summarize the clinically oriented functional imaging studies to date and to demonstrate the opportunities available in the clinical neurosciences that have been created by the availabilities of these new tools.
Audience: The intended audience includes neuropsychologists, neuropsychiatrists, and graduate students in cognitive neuroscience.
Features: The first of the book's three parts focuses on the underlying principles involved in functional brain imaging with chapters on PET, fMRI, EEG, and MEG. Part 2 reviews neuroimaging methods with application of the BOLD technique to neurologically impaired patients; network analysis in regards to normal and abnormal neural systems operations. Part 3 is clinically oriented, with chapters reviewing functional brain imaging studies in autism, neurosurgical planning in temporal lobe epilepsy, aphasia, traumatic brain injury, multiple sclerosis, alcohol intoxication, schizophrenia, aging, stroke recovery, and functional brain imaging implications for neurorehabilitation. This is a scholarly work, with pertinent and recent citations of the scientific literature at the end of each chapter. The index is especially helpful in a book covering a variety of disorders.
Assessment: This is an excellent book summarizing the field of functional brain imaging in neuropsychiatric disorders. If you are interested in keeping abreast of the scientific revolution in cognitive neuroscience, then this book is required reading.
From the Publisher

"This book is a highly useful reference for neuropsychologists and their students interested in imaging research. The contributors provide succinct and easily understood summaries of acquisition techniques, methods of analysis, and clinical applications of fMRI, PET, and other imaging modalities."--Paul Malloy, PhD, Butler Hospital and Brown University Medical School

"In the past two decades, there has been a revolution in the ability of investigators to observe alterations of physiological functions as well as neurotransmitters and the deposition of abnormal products in specific anatomic sites of the brain. Now these functional imaging techniques are beginning to influence the clinical practice of neurology and psychiatry. This excellent volume contains comprehensive reviews of these advances, written by many of the leaders in this field. For clinicians who deal with brain disorders and for clinical investigators, this book should be essential reading."--Kenneth M. Heilman, MD, Department of Neurology, University of Florida College of Medicine

"This is one of the first texts to focus on clinical applications of functioning neuroimaging, not just basic research. The book provides an excellent review of PET, fMRI, MEG, and EEG techniques, and highlights their potential for furthering the diagnosis and treatment of neurological and neuropsychiatric disorders. The contributors are leaders in their respective areas of study, and together they offer an up-to-date review and integration of this burgeoning field. The quality of writing and depth of coverage make this text an ideal selection for graduate courses in cognitive neuroscience and clinical neuropsychology."--Erin D. Bigler, PhD, Department of Psychology, Brigham Young University

Archives of Neurology

"The editors state in their preface that their volume represents an initial attempt to demonstrate the opportunities available in clinical neuroscience, and they definitely succeed in this purpose. This is a timely book for everybody interested in the present state of clinical applications for functional neuroimaging."--Archives of Neurology
Journal of Clinical and Experimental Neuropsychology

"The editors and contributors have done an exemplary job in balancing two elements critical to any book focused on functional neuroimaging in clinical conditions. First, the book maintains a superb balance of technical detail and simple explanation. Indeed, the work is among the best I have read that consistently provides sufficient detail to describe highly technical elements of imaging, without overburdening the reader through the process. An important application of this is that the book will appeal to a broad readership, including individuals with solid backgrounds in one or more aspects of the imaging methodologies reviewed in the book, but also to individuals with solid backgrounds in one or more aspects of the imaging methodologies with less defined experience in functional neuroimaging....Second, the editors and contributors effectively communicate multiple themes throughout the book, including the basic technical underpinnings of functional imaging, methodological applications and limits of these approaches, as well as the outcomes that have informed us about specific clinical conditions....A separate strength of this book in comparison to others that have been written on the topic to date is the focus on clinical populations....This an excellent book that reviews the basics of signal generation, key elements of methodology, and outcomes from research in clinical populations. The focus on clinical populations provides new information about brain organization and function, and this is a unique aspect compared to other available texts. Given these strengths, I anticipate that both research- and clinically oriented neuropsychologists will very much appreciate this book as an opportunity to 'see the brain action.'"--Journal of Clinical and Experimental Neuropsychology
The Journal of Nervous and Mental Disease

"This volume does double duty as an introduction to the currently used major functioning imaging tools, and their use in evaluating selected clinical populations....This is a useful introduction to its field, suitable for residents and graduate students."--The Journal of Nervous and Mental Disease
Archives of Clinical Neuropsychology

"An excellent single resource for the current status of clinical functional neuroimaging....It demonstrates the great potential of functional neuroimaging as well as the numerous challenges faced by this young field. It would be an ideal text for a speciality graduate seminar as well as a useful desk reference....After you finish the book, you will have a historical and current perspective on functional neuroimaging and may even appreciate the evolution in brain-behavior research we are currently experiencing....Has a sense of optimism and provides clear direction for future research. It seems to capture the mood and energy of a changing field. The careful reader will be abundantly rewarded for digesting this volume."--Archives of Clinical Neuropsychology
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Product Details

  • ISBN-13: 9781593854799
  • Publisher: Guilford Publications, Inc.
  • Publication date: 6/25/2007
  • Edition description: New Edition
  • Pages: 414
  • Product dimensions: 6.28 (w) x 10.88 (h) x 1.04 (d)

Meet the Author

Frank G. Hillary, PhD, is Assistant Professor in the Department of Psychology at Pennsylvania State University and holds faculty positions in the Departments of Neurology and Psychiatry at Hershey Medical Center in Hershey, Pennsylvania, and in the Department of Radiology at the University of Medicine and Dentistry of New Jersey-New Jersey Medical School in Newark. Dr. Hillary’s research examines neural plasticity and recovery from brain injury and disease in humans using various MRI techniques, such as magnetic resonance spectroscopy, diffusion tensor imaging, and fMRI. His current work examining the influence of brain trauma on the fMRI signal is funded by the National Institutes of Health.

John DeLuca, PhD, ABPP, is the Director of Neuroscience Research and Vice President for Research Training at the Kessler Medical Rehabilitation Research and Education Corporation; Professor in the Departments of Physical Medicine and Rehabilitation and Neurosciences at the University of Medicine and Dentistry of New Jersey-New Jersey Medical School; and a licensed psychologist in New Jersey and New York. Dr. DeLuca is currently studying disorders of memory and information processing in a variety of clinical populations, including multiple sclerosis, aneurysmal subarachnoid hemorrhage, chronic fatigue syndrome, and traumatic brain injury. He has published more than 300 articles, abstracts, and chapters, and serves on the editorial boards of several journals, including the Archives of Physical Medicine and Rehabilitation, Rehabilitation Psychology, and Neuropsychology Review. Dr. DeLuca is a recipient of early career awards from the American Psychological Association (Division 40, Clinical Neuropsychology) and the National Academy of Neuropsychology, as well as the Distinguished Researcher Award from the New Jersey Psychological Association.

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Table of Contents

I. Principles of Functional Imaging

1. Principles of Positron Emission Tomography, Balázs Gulyás and Nils Sjöholm

2. Principles of Functional Magnetic Resonance Imaging, Peter A. Bandettini

3. Principles of Electroencephalography and Magnetoencephalography, Anto Bajic and Susumu Sato

II. Neuroimaging Methods

4. Considerations for the Application of BOLD Functional Magnetic Resonance Imaging to Neurologically Impaired Populations, Adam Gazzaley and Mark D’Esposito

5. Network Analysis of the Human Brain: Applications to Understanding Normal and Abnormal Neural System Operations, Anthony R. McIntosh and Cheryl L. Grady

III. Clinical Applications

6. Functional Neuroimaging of Developmental Disorders: Lessons from Autism Research, Ralph-Axel Müller

7. Functional Magnetic Resonance Imaging in Neurosurgical Planning: Language, Memory, and Seizure Outcome in Temporal Lobe Epilepsy, Brenna C. McDonald and Andrew J. Saykin

8. Functional Neuroimaging of Impaired Language in Aphasia, Bruce Crosson

9. Functional Neuroimaging of Traumatic Brain Injury, Helen M. Genova, Neal M. Fitzpatrick, and Frank G. Hillary

10. Functional Neuroimaging in Multiple Sclerosis, Gerald T. Voelbel, Nancy D. Chiaravalloti, and John DeLuca

11. Alcohol Intoxication and Brain Imaging: Challenges and Findings, Vince D. Calhoun and Godfrey D. Pearlson

12. Functional Neuroimaging in Schizophrenia, J. Daniel Ragland

13. Testing Hypotheses of Age-Related Performance Changes Using Functional Magnetic Resonance Imaging, Bart Rypma

14. Functional Neuroimaging in Recovery from Stroke, Elizabeth R. Orr, Rachelle W. Rodriguez, and Steven C. Cramer

15. Implications of Functional Neuroimaging in Neurorehabilitation, Joseph H. Ricker

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