Fundamentals of Biochemistry: Life at the Molecular Level / Edition 4

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Voet and Pratt's 4th edition of Principles ofBiochemistry, challenges readers to better understand thechemistry behind the biological structure and reactions occurringin living systems. The latest edition continues this tradition,and additionally incorporates coverage of recent research andan expanded focus on preparing and supporting students throughoutthe course. With the addition of new conceptualassessment content to WileyPLUS, providing the opportunityto assess conceptual understanding of key introductorybiochemistry concepts and retrain themselves on theirmisconceptions

WileyPLUS sold separately from text.

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Editorial Reviews

Doody's Review Service
Reviewer: Sophie La Salle, PhD (Midwestern University Chicago College of Osteopathic Medicine)
Description: This book offers a broad, in-depth foundation of basic biochemical concepts by anchoring the biological content in its chemistry roots. This edition has been updated with the latest findings in biochemistry and their connection to human health, artwork to provide a clearer learning experience, and approaches to favor active learning. The previous edition was published in 2008.
Purpose: It serves many purposes, including delivering a solid foundation in modern biochemistry, developing problem-solving skills, and providing the historical background behind important biochemical discoveries. It is a complete guide to foundational biochemistry.
Audience: Although written for health sciences undergraduate and graduate students, the book may be used by premedical, medical, and other healthcare graduate students as a thorough reference. The authors are highly regarded educators, researchers, and teachers.
Features: Five major sections - an introduction, biomolecules, enzymes, metabolism and gene expression and replication — cover topics in modern biochemistry in the context of their chemical basis to help students understand the molecular foundation of biochemical reactions. In light of recent research findings, there is an emphasis on human health and diseases as well as novel pharmacological effectors. The book is well organized and beautifully illustrated, the artwork has been extensively revised, and process diagrams are clearly identified. It is enhanced with features that promote learning and self-assessment. For example, it includes "Key Concepts," reviews chemical principles when appropriate, provides sample calculations, contains "Checkpoint Questions" at the end of every section, and presents new end-of-chapter problems. It also contains a helpful glossary and a detailed index. The book is designed to provide a strong foundation in biochemistry by fostering student understanding rather than memorization.
Assessment: This is a magnificent textbook on biochemistry principles. (Readers looking for a quick review are advised to choose another book.) This edition includes up-to-date information and favors active learning by expanding its pedagogical tools and approaches. This book is of comparable caliber and coverage as Lehninger Principles of Biochemistry, 6th edition, Nelson and Cox, (W.H. Freeman, 2013). Students will certainly acquire a solid basis in biochemistry with this textbook.
From The Critics
Donald Voet (U. of Pennsylvania) and Judith G. Voet (Swarthmore), two of this text's three authors (the third is Charlotte W. Pratt) already have under their belts a larger text, . The present text retains the philosophy of the earlier book, but it is less detailed and constitutes a re-vamped treatment of the subject both in organization and style. The material is organized to correspond with how the authors teach the course, but detailed division into sections and subsections allows instructors with other ideas to organize courses to their own tastes without apprehension that they've missed critical information. The included CD-ROM contains a variety of interactive three-dimensional molecular graphics displays and animations. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780470547847
  • Publisher: Wiley
  • Publication date: 1/11/2012
  • Edition description: New Edition
  • Edition number: 4
  • Pages: 1200
  • Sales rank: 157,939
  • Product dimensions: 8.80 (w) x 11.10 (h) x 1.80 (d)

Meet the Author

Donald Voet received a B.S. in Chemistry from the California Institute of Technology, a Ph.D. in Chemistry from Harvard University with William Lipscomb, and did postdoctoral research in the Biology Department at MIT with Alexander Rich. Upon completion of his postdoctoral research, Don took up a faculty position in the Chemistry Department at the University of Pennsylvania where, for the past 38 years, he has taught a variety of Biochemistry courses as well as general Chemistry. His major area of research is the X-ray crystallography of molecules of biological interest. He has been a visiting scholar at Oxford University, The University of California at San Diego, and the Weizmann Institute of Science in Israel. Together with Judith G. Voet, he is Co-Editor-in-Chief of the journal Biochemistry and Molecular Biology Education. He is a member of the Education Committee of the International Union of Biochemistry and Molecular Biology. His hobbies include backpacking, scuba diving, skiing, travel, photography, and writing Biochemistry textbooks.

Judith ("Judy") Voet received her B.S. in Chemistry from Antioch College and her Ph.D. in Biochemistry from Brandeis University with Robert H. Abeles. She has done postdoctoral research at the University of Pennsylvania, Haverford College, and the Fox Chase Cancer Center. Her main area of research involves enzyme reaction mechanisms and inhibition. She taught Biochemistry at the University of Delaware before moving to Swarthmore College. She taught there for 26 years, reaching the position of James H. Hammons Professor of Chemistry and Biochemistry before going on "permanent sabbatical leave." She has been a visiting scholar at Oxford University, University of California, San Diego, University of Pennsylvania, and the Weizmann Institute of Science, Israel. She is Co-Editor-in-Chief of the journal Biochemistry and Molecular Biology Education. She has been a member of the Education and Professional Development Committee of the American Society for Biochemistry and Molecular Biology as well as the Education Committee of the International Union of Biochemistry and Molecular Biology. Her hobbies include hiking, backpacking, scuba diving, and tap dancing.

Charlotte Pratt received her B.S. in Biology from the University of Notre Dame and her Ph.D. in Biochemistry from Duke University under the direction of Salvatore Pizzo. Although she originally intended to be a marine biologist, she discovered that Biochemistry offered the most compelling answers to many questions about biological structure-function relationships and the molecular basis for human health and disease. She conducted postdoctoral researching the Center for Thrombosis and Hemostasis at the University of North Carolina at Chapel Hill. She has taught at the University of Washington and currently teaches at Seattle Pacific University. In addition to working as an editor of several Biochemistry textbooks, she has co-authored Essential Biochemistry and previous editions of Fundamentals of Biochemistry.

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Table of Contents

1 Introduction to the Chemistry of Life
2 Water

3 Nucleotides, Nucleic Acids, and Genetic Information
4 Amino Acids
5 Proteins: Primary Structure
6 Proteins: Three-Dimensional Structure
7 Protein Function: Myoglobin and Hemoglobin, Muscle Contraction, and Antibodies
8 Carbohydrates
9 Lipids and Biological Membranes
10 Membrane Transport

12 Enzyme Kinetics, Inhibition, and Control
13 Biochemical Signaling

14 Introduction to Metabolism
15 Glucose Catabolism
16 Glycogen Metabolism and Gluconeogenesis
17 Citric Acid Cycle
18 Electron Transport and Oxidative Phosphorylation
19 Photosynthesis
20 Lipid Metabolism
21 Amino Acid Metabolism
22 Mammalian Fuel Metabolism: Integration and Regulation

23 Nucleotide Metabolism
24 Nucleic Acid Structure
25 DNA Replication, Repair, and Recombination
26 Transcription and RNA Processing
27 Protein Synthesis
28 Regulation of Gene Expression

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  • Anonymous

    Posted September 4, 2014

    Despite being assured, multiple times, that this product does co

    Despite being assured, multiple times, that this product does contain the WileyPlus online access code, this product doesn't. It took having a new replacement copy for the textbook to arrive sans access code for someone in customer service to realize the error. Also, the expedited shipping took three days to arrive, irregardless of the two day shipping guarantee. If possible do not buy textbooks from Barnes and Noble, unless you are looking for disappointment.

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    Posted February 6, 2013

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