Fundamentals of Biochemistry: Life at the Molecular Level / Edition 3

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Fundamentals of Biochemistry, 2nd edition is a carefully organized, clearly written, and generously illustrated survey of the structures of biological molecules, the metabolic activities of cells, and the principles of molecular biology. The authors also include descriptions of major analytical techniques and wherever possible, correlate biochemical knowledge with human health and disease.
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Editorial Reviews

From The Critics
Donald Voet (U. of Pennsylvania) and Judith G. Voet (Swarthmore), two of this text's three authors (the third is Charlotte W. Pratt) already have under their belts a larger text, . The present text retains the philosophy of the earlier book, but it is less detailed and constitutes a re-vamped treatment of the subject both in organization and style. The material is organized to correspond with how the authors teach the course, but detailed division into sections and subsections allows instructors with other ideas to organize courses to their own tastes without apprehension that they've missed critical information. The included CD-ROM contains a variety of interactive three-dimensional molecular graphics displays and animations. Annotation c. Book News, Inc., Portland, OR (
Doody's Review Service
Reviewer: Sophie La Salle, PhD (Midwestern University Chicago College of Osteopathic Medicine)
Description: This book offers a broad, in-depth foundation of basic biochemical concepts by anchoring the biological content in its chemistry roots. This edition has been updated with the latest findings in biochemistry and their connection to human health, artwork to provide a clearer learning experience, and approaches to favor active learning. The previous edition was published in 2008.
Purpose: It serves many purposes, including delivering a solid foundation in modern biochemistry, developing problem-solving skills, and providing the historical background behind important biochemical discoveries. It is a complete guide to foundational biochemistry.
Audience: Although written for health sciences undergraduate and graduate students, the book may be used by premedical, medical, and other healthcare graduate students as a thorough reference. The authors are highly regarded educators, researchers, and teachers.
Features: Five major sections - an introduction, biomolecules, enzymes, metabolism and gene expression and replication — cover topics in modern biochemistry in the context of their chemical basis to help students understand the molecular foundation of biochemical reactions. In light of recent research findings, there is an emphasis on human health and diseases as well as novel pharmacological effectors. The book is well organized and beautifully illustrated, the artwork has been extensively revised, and process diagrams are clearly identified. It is enhanced with features that promote learning and self-assessment. For example, it includes "Key Concepts," reviews chemical principles when appropriate, provides sample calculations, contains "Checkpoint Questions" at the end of every section, and presents new end-of-chapter problems. It also contains a helpful glossary and a detailed index. The book is designed to provide a strong foundation in biochemistry by fostering student understanding rather than memorization.
Assessment: This is a magnificent textbook on biochemistry principles. (Readers looking for a quick review are advised to choose another book.) This edition includes up-to-date information and favors active learning by expanding its pedagogical tools and approaches. This book is of comparable caliber and coverage as Lehninger Principles of Biochemistry, 6th edition, Nelson and Cox, (W.H. Freeman, 2013). Students will certainly acquire a solid basis in biochemistry with this textbook.
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Product Details

  • ISBN-13: 9780470129302
  • Publisher: Wiley
  • Publication date: 1/9/2008
  • Edition description: Older Edition
  • Edition number: 3
  • Pages: 1240
  • Product dimensions: 8.60 (w) x 11.10 (h) x 1.80 (d)

Meet the Author

Donald Voet received a B.S. in Chemistry from the California Institute of Technology, a Ph.D. in Chemistry from Harvard University with William Lipscomb, and did postdoctoral research in the Biology Department at MIT with Alexander Rich. Upon completion of his postdoctoral research, Don took up a faculty position in the Chemistry Department at the University of Pennsylvania where, for the past 38 years, he has taught a variety of Biochemistry courses as well as general Chemistry. His major area of research is the X-ray crystallography of molecules of biological interest. He has been a visiting scholar at Oxford University, The University of California at San Diego, and the Weizmann Institute of Science in Israel. Together with Judith G. Voet, he is Co-Editor-in-Chief of the journal Biochemistry and Molecular Biology Education. He is a member of the Education Committee of the International Union of Biochemistry and Molecular Biology. His hobbies include backpacking, scuba diving, skiing, travel, photography, and writing Biochemistry textbooks.

Judith ("Judy") Voet received her B.S. in Chemistry from Antioch College and her Ph.D. in Biochemistry from Brandeis University with Robert H. Abeles. She has done postdoctoral research at the University of Pennsylvania, Haverford College, and the Fox Chase Cancer Center. Her main area of research involves enzyme reaction mechanisms and inhibition. She taught Biochemistry at the University of Delaware before moving to Swarthmore College. She taught there for 26 years, reaching the position of James H. Hammons Professor of Chemistry and Biochemistry before going on "permanent sabbatical leave." She has been a visiting scholar at Oxford University, University of California, San Diego, University of Pennsylvania, and the Weizmann Institute of Science, Israel. She is Co-Editor-in-Chief of the journal Biochemistry and Molecular Biology Education. She has been a member of the Education and Professional Development Committee of the American Society for Biochemistry and Molecular Biology as well as the Education Committee of the International Union of Biochemistry and Molecular Biology. Her hobbies include hiking, backpacking, scuba diving, and tap dancing.

Charlotte Pratt received her B.S. in Biology from the University of Notre Dame and her Ph.D. in Biochemistry from Duke University under the direction of Salvatore Pizzo. Although she originally intended to be a marine biologist, she discovered that Biochemistry offered the most compelling answers to many questions about biological structure-function relationships and the molecular basis for human health and disease. She conducted postdoctoral researching the Center for Thrombosis and Hemostasis at the University of North Carolina at Chapel Hill. She has taught at the University of Washington and currently teaches at Seattle Pacific University. In addition to working as an editor of several Biochemistry textbooks, she has co-authored Essential Biochemistry and previous editions of Fundamentals of Biochemistry.

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Table of Contents

Ch. 1 Introduction to the chemistry of life 2
Ch. 2 Water 22
Ch. 3 Nucleotides, nucleic acids, and genetic information 40
Ch. 4 Amino acids 76
Ch. 5 Proteins : primary structure 94
Ch. 6 Proteins : three-dimensional structure 129
Ch. 7 Protein function : myoglobin and hemoglobin 181
Ch. 8 Carbohydrates 206
Ch. 9 Lipids and biological membranes 233
Ch. 10 Membrane transport 284
Ch. 11 Enzymatic catalysis 312
Ch. 12 Enzyme kinetics, inhibition, and regulation 357
Ch. 13 Introduction to metabolism 395
Ch. 14 Glucose catabolism 427
Ch. 15 Glycogen metabolism and gluconeogenesis 472
Ch. 16 Citric acid cycle 514
Ch. 17 Electron transport and oxidative phosphorylation 545
Ch. 18 Photosynthesis 590
Ch. 19 Lipid metabolism 627
Ch. 20 Amino acid metabolism 682
Ch. 21 Mammalian fuel metabolism : integration and regulation 743
Ch. 22 Nucleotide metabolism 787
Ch. 23 Nucleic acid structure 817
Ch. 24 DNA replication, repair, and recombination 867
Ch. 25 Transcription and RNA processing 919
Ch. 26 Translation 960
Ch. 27 Regulation of gene expression 1010
Ch. 28 Protein function part II : cytoskeletal and motor proteins and antibodies 1072
App Bioinformatics exercises 1115
App Answers to bioinformatics exercises 1124
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