Fundamentals of Medicinal Chemistry / Edition 1

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10/03/2003 Hardcover Very good Ships from the UK within 24 hours. No Dustjacket. *****PLEASE NOTE: This item is shipping from an authorized seller in Europe. In the event that ... a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

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Overview

Fundamentals of Medicinal Chemistry is a concise introduction to the chemistry of therapeutically active compounds, written in a readable and accessible style. Opening with a review of the structures and nomenclature of the more common classes of naturally occurring compounds found in biological organisms, the text then covers the discovery and design of drugs, pharmacokinetics and drug metabolism. The book concludes with a chapter on organic synthesis, followed by a brief look at drug development from the research stage through to marketing of the final product. The text assumes little in the way of prior biological knowledge and only a basic chemical knowledge. Relevant biology is included through biological topics, examples and in the Appendices.
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Editorial Reviews

From the Publisher
"…it would be of great value to beginning graduate students in medicinal chemistry…it should be included in any practicing chemist's personal library." (Journal of Medicinal Chemistry, July 29, 2004)

"Thomas presents the fundamentals of medicinal chemistry in a clear, concise, and descriptive fashion.” (Choice, June 2004, Vol. 41 No. 10)

"...provides a concise introduction to the chemistry of therapeutically active compounds, written in a readable and accessible style..." (www.organische-chemie.ch, 19/01/2004)

“…well laid out, with an attractive typeface.” (Chemistry and Industry, 6th September 2004)

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Product Details

  • ISBN-13: 9780470843062
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 11/14/2003
  • Edition number: 1
  • Pages: 302
  • Product dimensions: 7.44 (w) x 9.69 (h) x 0.94 (d)

Table of Contents

Preface
Acknowledgements
Abbreviations/Acronyms
1 Biological Molecules 1
2 An Introduction to Drugs and their Action 37
3 An Introduction to Drug Discovery 57
4 The SAR and QSAR Approaches to Drug Design 71
5 Computer Aided Drug Design 95
6 Combinatorial Chemistry 113
7 Selected Examples of Drug Action at some Common Target Areas 131
8 Pharmacokinetics 159
9 Drug Metabolism 181
10 An Introduction to Lead and Analogue Syntheses 203
11 Drug Development and Production 223
Appendix 239
Answers to Questions 261
Selected Further Reading 273
Index 275
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