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Doody's Review ServiceReviewer: Joan M. Mankowski, MD (University of Illinois at Chicago)
Description: This is an organ system-based textbook of current principles and knowledge in toxicologic pathology.
Purpose: The purpose is to provide a condensed and updated version of the editors' 1991 reference text, the Handbook of Toxicologic Pathology. It describes the morphologic and structural affects of toxicants and the basic mechanisms which produce those changes. This revision foregoes the detailed description of mechanisms and descriptive morphology while retaining the core material. The editors have succeeded in producing a very readable, basic textbook of current toxicologic pathology.
Audience: The book's intended audience spans a wide spectrum from graduate students in toxicology, pathology, and environmental sciences to academic scientists and hospital pathologists. Its emphasis on core principles and mechanisms will prove most beneficial to graduate students and those requiring less detailed information.
Features: The book provides many high quality, well labeled reproductions of light and electron micrographs. The diagrams and tables generally achieve the correct balance of completeness and conciseness. The end of chapter suggested readings are up to date, although somewhat scant. A glossary completing the chapter on chemical carcinogenesis is a thoughtful and useful feature.
Assessment: This book will be an excellent resource for graduate students in toxicology, pathology, and environmental health studies. It provides a thorough organ system based overview of current knowledge and fundamental principles of toxicologic pathology, devoid of the detailed treatment of descriptive morphology and mechanisms provided in reference texts.