Fundus Autofluorescence

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Featuring over 250 illustrations, this detailed full-color textbook provides up-to-date information on the use of fundus autofluorescence imaging in the evaluation of retinal disease. The basic science chapters explain the synthesis and degradation of lipofuscin, the main fluorophore in the retina generating the fundus autofluorescence signal; the techniques available to image and quantify fundus autofluorescence and their basis; and the anatomo-pathologic correlations of autofluorescence findings. The clinical science chapters describe the distribution of autofluorescence across the fundus in the healthy eye and in various diseases—age-related maculopathy and macular degeneration, inherited retinal dystrophies, posterior uveitis, central serous chorioretinopathy, macular holes and related conditions, and intraocular tumors.

Emphasis is on the value of fundus autofluorescence as a diagnostic and prognostic tool. The authors discuss the clinical utility of fundus autofluorescence in the context of other imaging techniques, such as fluorescein and indocyanine green angiography and optical coherence tomography. Each chapter also points out the value of fundus autofluorescence findings in understanding the pathogenesis of the condition, and provides a comprehensive update on all aspects of the condition.

A companion Website will offer the fully searchable text and an image bank.

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Editorial Reviews

From the Publisher

"This book is an excellent comprehensive text on Fundus Autofluorescence...The illustrations provide an excellent correlation between colour photos, fundus fluorescein angiography (FFA), optical coherence tomography (OCT), and FAF...A must for ophthalmologists dealing with retinal diseases generally but particularly for clinicians involved in the management of inherited retinal diseases and macular degeneration."

Eye News, April/May 2010

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Product Details

  • ISBN-13: 9781582557991
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 7/1/2009
  • Pages: 400
  • Product dimensions: 8.60 (w) x 11.10 (h) x 0.70 (d)

Table of Contents


1. Lipofuscin: The "Wear and Tear" Pigment
Sabrina S. Seehafer and David. A. Pearce

2. Lipofuscin of the Retinal Pigment Epithelium
Michael E. Boulton

3. Lipofuscin: The Origin of the Autofluorescence Signal
François Delori

4. Lipofuscin and Autofluorescence in Experimental Animal Models
Heping Xu

5. Imaging Techniques of Fundus Autofluorescence
Steffen Schmitz-Valckenberg and Fred W. Fitzke

6. Near-Infrared Fundus Autofluorescence
Ulrich Kellner and Simone Kellner

7. Interpreting Fundus Autofluorescence
Alan C. Bird

8. Quantifying Fundus Autofluorescence
Dietrich Schweitzer


Fundus Autofluorescence in the Healthy Eye

9. Fundus Autofluorescence in the Healthy Eye
R. Theodore Smith

Fundus Autofluorescence in the Diseased Eye

10. Age-Related Maculopathy and Age-Related Macular Degeneration

10A. Fundus Autofluorescence in Age-Related Maculopathy
Almut Bindewald-Wittich, Robert P. Finger, and Frank G. Holz

10B. Fundus Autofluorescence in Neovascular Age-Related Macular Degeneration
Ehab Abdelkader, Vikki McBain, and Noemi Lois

10C. Fundus Autofluorescence in Atrophic Age-Related Macular Degeneration
Steffen Schmitz-Valckenberg, Monika Fleckenstein, Almut Bindewald-Wittich, Hendrik P.N. Scholl, and Frank G. Holz

11. Inherited Retinal Dystrophies

11A. Fundus Autofluorescence in Retinitis Pigmentosa
Anthony G. Robson, Isabelle Audo, Phil Hykin, and Andrew R. Webster

11B. Fundus Autofluorescence in Cone and Cone-Rod Dystrophies
Michel Michaelides

11C. Fundus Autofluorescence in X-linked Retinoschisis
Irena Tsui and Stephen H. Tsang

11D. Fundus Autofluorescence in Leber Congenital Amaurosis
Hendrik P.N. Scholl and Bettina Wabbels

11E. Fundus Autofluorescence in Pattern Dystrophy
Susan M. Downes

11F. Fundus Autofluorescence in Best Disease
Markus Preising

11G. Fundus Autofluorescence in Stargardt's Disease
Vikki McBain and Noemi Lois

11H. Fundus Autofluorescence in Maternal Inherited Diabetes and Deafness (MIDD)
Caren Bellmann and Pamela Rath

11I. Fundus Autofluorescence in Choroideremia
Agnes B. Renner

12. Fundus Autofluorescence in Posterior Uveitis
John V. Forrester, Lucia Kuffová, Vikki McBain, and Noemi Lois

13. Fundus Autofluorescence in Central Serous Chorioretinopathy
Carsten Framme

14. Macular Holes and Related Conditions

14A. Fundus Autofluorescence in Full-Thickness Macular Holes
Andrea von Rückmann

14B. Fundus Autofluorescence in Lamellar Macular Holes and Pseudoholes
Ferdinando Bottoni

15. Fundus Autofluorescence of Intraocular Tumors: Choroidal Nevus and Melanoma
Daniel Lavinsky, Rubens Belfort Mattos Neto, Eduardo V. Navajas, and Rubens Belfort Mattos, Jr.

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