G Proteins, Receptors, and Diseaseby Allen M. Spiegel
More than a collection of review articles, G Proteins, Receptors, and Disease summarizes in depth the state of our knowledge today concerning not only how cells communicate via G-protein-coupled signal transduction processes, but also how defects in these proteins and their receptors can cause serious human disease involving many different organ systems. Written by… See more details below
More than a collection of review articles, G Proteins, Receptors, and Disease summarizes in depth the state of our knowledge today concerning not only how cells communicate via G-protein-coupled signal transduction processes, but also how defects in these proteins and their receptors can cause serious human disease involving many different organ systems. Written by leading investigators, each chapter describes in detail the structure and function of a particular G protein or receptor, outlines possible mutations, and discusses fully the molecular pathogenesis of associated diseases. Diagnostic and therapeutic implications are also discussed when relevant.
In its unique blend of cutting-edge basic science and clinical medicine, G Proteins, Receptors, and Disease offers deep insights into the physiological significance of this key signal transduction pathway, as well as into the molecular basis of diseases ranging from obesity to malignancy. The basic understanding of the complex signal transduction process achieved here provides a firm foundation for future efforts to prevent and cure these diseases.
Description: Written by experts in the field, this book is a collection of reviews covering the major topics in G protein molecular biology. The contributors summarize the current understanding of molecular defects involving G protein and G protein coupled receptors in human diseases and animal models.
Purpose: The stated purpose is to provide the reader with a complete review of the known molecular and genetic details of the G protein signal cascade and related disease. This objective is worthy; a single volume compilation of the current state of G protein related research will be a valuable resource for many researchers. The book meets the stated objective effectively, particularly because of the selection of experts who wrote the chapters.
Audience: The appropriate audience is researchers in a variety of fields whose interests involve G protein and G protein coupled receptor molecular biology and diseases, as well as progressive clinicians who deal with certain genetic diseases. The authority of the contributors is undisputed.
Features: The chapters are quite up-to-date. Each chapter is truly a state-of-the-art description. For example, Vassart's chapter on "hypo-hyperthyroidism caused by mutations of the TSH receptor" and the chapter by Koch and Lefkowitz on "altering adrenergic signaling and cardiac function" are excellent. The contributors provide the reader with appropriate and clear illustrations that contribute to the ease of understanding the subject. The references cited are significant publications that represent important contributions to the molecular and genetic knowledge of this topic.
Assessment: The subject matter is clearly expressed and the enthusiasm of the contributors is tangible. This book is appropriate for purchase by medical libraries, medical bookstores, and individuals as well. I would recommend it to those who would like to update their knowledge in the field of G proteins, G protein coupled receptors, signal transduction, and diseases.
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