Galectins / Edition 1

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This is the first book focusing on galectins. It was inspired by topics discussed at the symposium "Galectins: Structures, Functions, and Therapeutic Targets" that was a part of the 234th American Chemical Society meeting in 2007. To help chemists, biochemists, and others understand the challenges inherent in the study of galectins and build on recent advances in the field, the editors have compiled articles from leading experts on galectins and their biomedical applications. Galectins includes:

An overview of early galectin research

An explanation of the nature of galectins

A discussion of the structure and functions of galectins, their ligand specificity and molecular mechanisms of action, and the localization of galectins in the cell

An exploration of the roles galectins play in tumor growth and cancer, fibrosis, inflammation, and immunity

A discussion of the effect of galectins on cell migration, angiogenesis, and chemoresistance

An introduction to new approaches to designing galectin inhibitors

This is the premier reference on galectins for organic, medicinal, carbohydrate, and pharmaceutical chemists, biochemists, molecular and cell biologists, pharmacologists, cancer researchers, and graduate-level students in these disciplines, as well as clinicians and drug developers.

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Editorial Reviews

From the Publisher
"The book is the first galectin book and contains a wealth of information … .The chapters provide researchers with a solid overview of the state of the art in the various subjects and will be useful to many galectin researchers." (ChemBioChem, January 2009)

"A comprehensive guide to the current understanding of galectins, their promising potential in drug design." (Forbes, June 2008)

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Product Details

  • ISBN-13: 9780470373187
  • Publisher: Wiley
  • Publication date: 6/27/2008
  • Edition number: 1
  • Pages: 288
  • Product dimensions: 6.10 (w) x 9.20 (h) x 1.10 (d)

Meet the Author

Anatole A. Klyosov, PhD, is Chief Scientist and cofounder of Pro-Pharma-ceuticals, Inc. He has published more than 290 peer-reviewed articles in scientific journals; authored and edited books on enzymes, carbohydrates, and biotechnology, including Wood-Plastic Composites (Wiley); and holds thirty-nine patents.

Zbigniew J. Witczak, PhD, has extensive industrial and academic experience in carbohydrates. He has published more than ninety research papers and holds six patents in the fields of carbohydrate, medicinal, and biological chemistry. In 2000, Dr. Witczak was awarded the Melville L. Wolfrom Award of the ACS Division of Carbohydrate Chemistry for his outstanding research contribution to carbohydrate chemistry and service to the division.

David Platt, PhD, is Chief Executive Officer and cofounder of Pro-Pharmaceuticals, Inc. He has published peer-reviewed articles and holds many patents, primarily in the field of carbohydrate chemistry. Dr. Klyosov, Dr. Witczak, and Dr. Platt coedited the ACS symposium book Carbohydrate Drug Design.

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Table of Contents

Preface vii

Contributors ix

1 Stumbling on Galectins Samuel H. Barondes 1

2 Galectins and Their Functions in Plain Language Anatole A. Klyosov 9

3 Understanding Galectin Structure-Function Relationships to Design Effective Antagonists Irina V. Nesmelova Ruud P.M. Dings Kevin H. Mayo 33

4 Galectins as Regulators of Tumor Growth and Invasion by Targeting Distinct Cell Surface Glycans and Implications for Drug Design Hans-Joachim Gabius Albert M. Wu 71

5 Nuclear and Cytoplasmic Localization of Galectin-1 and Galectin-3 and Their Roles in Pre-mRNA Splicing John L. Wang Kevin C. Haudek Patricia G. Voss Ronald J. Patterson 87

6 Galectins in Regulation of Inflammation and Immunity Fu-Tong Liu Daniel K. Hsu Ri-Yao Yang Huan-Yuan Chen Jun Saegusa 97

7 Galectins as Danger Signals in Host-Pathogen and Host-Tumor Interactions: New Members of the Growing Group of "Alarmins"? Sachiko Sato Gabriel A. Rabinovich 115

8 The Role of Galectins in Organ Fibrosis Neil C. Henderson Tariq Sethi 147

9 Galecitin-1, Cancer Cell Migration, Angiogenesis, and Chemoresistance Florence Lefranc Marie Le Mercier Véronique Mathieu Robert Kiss 157

10 Galectin-3 in the Progression and Metastasis of Colorectal Neoplasia James C. Byrd Robert S. Bresalier 193

11 Galectins in Malignant Gliomas: Expression, Functions, and Possible Therapeutic Options Herwig M. Strik Anna Hoffmann 223

12 Food-Related Carbohydrate Ligands for Galectins Valeri V. Mossine Vladislav V. Glinsky Thomas P. Mawhinney 235

Index 271

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