Gas Chromatography and Mass Spectrometry: A Practical Guide

by O. David Sparkman, Zelda Penton, Fulton G. Kitson

Overview

The second edition of Gas Chromatography and Mass Spectrometry: A Practical Guide follows the highly successful first edition by F.G. Kitson, B.S. Larsen, and C.N. McEwen (1996), which was designed as an indispensible resource for GC/MS practitioners regardless of whether they are a novice or well experienced. The Fundamentals section has been extensively reworked from the original edition to give more depth of an understanding of the techniques and science involved with GC/MS. Even with this expansion, the original brevity and simple didactic style has been retained. Information on chromatographic peak deconvolution has been added along with a more in-depth understanding of the use of mass spectral databases in the identification of unknowns. Since the last edition, a number of advances in GC inlet systems and sample introduction techniques have occurred, and they are included in the new edition. Other updates include a discussion on fast GC and options for combining GC detectors with mass spectrometry. The section regarding GC Conditions, Derivatization, and Mass Spectral Interpretation of Specific Compound Types has the same number of compound types as the original edition, but the information in each section has been expanded to not only explain some of the spectra but to also explain why certain fragmentations take place. The number of Appendices has been increased from 12 to 17. The Appendix on Atomic Masses and Isotope Abundances has been expanded to provide tools to aid in determination of elemental composition from isotope peak intensity ratios. An appendix with examples on "Steps to follow in the determination of elemental compositions based on isotope peak intensities" has been added. Appendices on whether to use GC/MS or LC/MS, third-party software for use in data analysis, list of information required in reporting GC/MS data, X+1 and X+2 peak relative intensities based on the number of atoms of carbon in an ion, and list of available EI mass spectral databases have been added. Others such as the ones on derivatization, isotope peak patterns for ions with Cl and/or Br, terms used in GC and in mass spectrometry, and tips on setting up, maintaining and troubleshooting a GC/MS system have all been expanded and updated. - Covers the practical instruction necessary for successful operation of GC/MS equipment - Reviews the latest advances in instrumentation, ionization methods, and quantitation - Includes troubleshooting techniques and a variety of additional information useful for the GC/MS practitioner - A true benchtop reference - A guide to a basic understanding of the components of a Gas Chromatograph-Mass Spectrometer (GC-MS) - Quick References to data interpretation - Ready source for information on new analyses

Product Details

ISBN-13:	9780080920153
Publisher:	Elsevier Science & Technology Books
Publication date:	05/17/2011
Sold by:	Barnes & Noble
Format:	eBook
Pages:	632
File size:	13 MB
Note:	This product may take a few minutes to download.

Table of Contents

PrefaceAcknowledgmentsSection 1 THE FUNDAMENTALS OF GC/MS1 Introduction and History2 Gas Chromatography3 The GC/MS Interface4 Mass Spectrometry Instrumentation5 Mass Spectral Data Interpretation6 Quantitation with GC/MSSection 2 GC CONDITIONS, DERIVATIZATION, AND MASS SPECTRAL INTERPRETATION OF SPECIFIC COMPOUND TYPES7 Acids8 Alcohols9 Aldehydes10 Amides11 Amines12 Amino Acids13 Common Contaminants14 Drugs and Their Metabolites15 Esters16 Ethers17 Fluorinated Compounds18 Gases19 Glycols20 Halogenated Compounds (Other Than Fluorinated Compounds)21 Hydrocarbons22 Isocyanates23 Ketones24 Nitriles25 Nitroaromatics26 Nitrogen-Containing Heterocyclic Compounds27 Nucleosides (TMS Derivatives)28 Pesticides29 Phenols30 Phosphorus Compounds31 Plasticizers and Other Polymer Additives (Including Phthalates)32 Prostaglandins (MO–TMS Derivatives)33 Solvents and Their Impurities34 Steroids35 Sugars (Monosaccharides)36 Sulfur CompoundsSection 3 APPENDICESAppendix A Definitions of Terms Related to Gas ChromatographyAppendix B Definitions of Terms Related to Mass SpectrometryAppendix C Atomic Masses and Isotope Abundances and Other Information for the Determination of an Elemental Composition from Isotope Peak Intensity RatiosAppendix D X+1 and X+2 Values for Ions Containing Atoms of C and H Based on Isotope ContributionsAppendix E Isotope Peak Patterns for Ions Containing Atoms of Cl and/or BrAppendix F Steps to Follow in the Determination of an Elemental Composition Based on Isotope Peak Intensity RatiosAppendix G Derivatization in GC/MSAppendix H Points of Comparison of LC/MS vs GC/MSAppendix I List of Available EI Mass Spectral DatabasesAppendix J Information Required for Reporting a GC/MS AnalysisAppendix K Third-Party Software for Use with GC/MSAppendix L GC Installation and MaintenanceAppendix M Troubleshooting Common GC ProblemsAppendix N Maintenance, Operating Tips, and Troubleshooting for Mass SpectrometersAppendix O Mixtures for Determining Mass Spectral ResolutionAppendix P Cross-Index Chart for GC Stationary PhasesAppendix Q Ions for Determining Unknown StructuresIndex

What People are Saying About This

From the Publisher

An essential resource for the GC/MS practitioner

Editorial Reviews

"The authors have kept this book relevant and timely and have achieved their goal of providing useful information for practitioners. They understand what those who actually use GC/MS need, and continue to add appendixes of numerical information (increased from 12 to 17 in this revision)…The entire book has been updated and improved where needed; for example, chapter 6, covering the challenging topic of quantitation, has been "completely reworked." Sparkman and his collaborators continue to write high-quality books that are extremely useful, precise, and interesting to both novices and experienced scientists. Summing Up: Highly recommended. Upper-division undergraduates through professionals/practicioners."
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From the Publisher