Gene and Cell Therapy: Therapeutic Mechanisms and Strategies / Edition 3

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Since the publication of the second edition of this book in 2004, gene therapy and cell therapy clinical trials have yielded some remarkable successes and some disappointing failures. Now in its third edition, Gene and Cell Therapy: Therapeutic Mechanisms and Strategies assembles many of the new technical advances in gene delivery, clinical applications, and new approaches to the regulation and modification of gene expression.

New Topics Covered in this Edition:

  • Gene and Cell Therapies for Diabetes and Cardiovascular Diseases
  • Clinical Trials
  • Human Embryonic Stem Cells
  • Tissue Engineering Combined with Cell Therapies
  • Novel Polymers
  • Relevant Nanotechnologies
  • SiRNA Therapeutic Strategies
  • Dendrimer Technologies

Comprised of contributions from international experts, this book begins with a discussion of delivery systems and therapeutic strategies, exploring retroviral vectors and adenovirus vectors, as well as other therapeutic strategies.

The middle section focuses on gene expression and detection, followed by an examination of various therapeutic strategies for individual diseases, including hematopoietic disorders, cardiovascular conditions, cancer, diabetes, cystic fibrosis, neurological disorders, and childhood-onset blindness.

The final section discusses recent clinical trials and regulatory issues surrounding the new technology.

This compendium is assembled by noted molecular biologist and biochemist Nancy Smyth Templeton. Baylor College of Medicine and several other institutions have used Dr. Templeton’s non-viral therapeutics in clinical trials for the treatment of lung, breast, head and neck, and pancreatic cancers, as well as Hepatitis B and C. She continues to work at the forefront of research in gene and cell therapies. Her contributions, as well as those contained in this volume, are sure to advance the state of the art of these revolutionary life-saving technologies.

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Product Details

  • ISBN-13: 9780849387685
  • Publisher: Taylor & Francis
  • Publication date: 10/8/2008
  • Edition description: REV
  • Edition number: 3
  • Pages: 1120
  • Product dimensions: 8.90 (w) x 11.10 (h) x 2.30 (d)

Table of Contents

Delivery Systems and Therapeutic Strategies
Retroviral Vectors for Cell and Gene Therapy, A. Schambach, T. Maetzig, and C. Baum
Production of Retroviral Vectors: From the Producer Cell to the Final Product, P.E. Cruz, A.S. Coroadinha, T. Rodrigues, and H. Hauser
Adenovirus Vectors for Gene Therapy, N.R. Hackett and R.G. Crystal
Modified Adenoviruses for Gene Therapy, J.N. Glasgow, A. Hemminki, and D.T. Curiel
Helper-Dependent Adenoviral Vectors for Gene Therapy, N. Brunetti-Pierri and P. Ng
Adeno-Associated Virus and AAV Vectors for Gene Delivery, B.J. Carter, H. Burstein, and R.W. Peluso
Therapeutic Gene Transfer with Replication-Defective Herpes Simplex Viral Vectors, D. Wolfe, W.F. Goins, A. Frampton, M. Mata, D.J. Fink, and J.C. Glorioso
Oncolytic Viruses for Treatment of Cancer, M. Raki, M. Rajecki, D. Kirn, and A. Hemminki
Lentiviral Vectors, J.M. Felder III and R. Sutton
Vaccinia Viral Vectors, J.A. McCart and D.L. Bartlett
Baculovirus-Mediated Gene Transfer: An Emerging Universal Concept, K.J. Airenne, A.J. Mähönen, O.H. Laitinen, and S. Ylä-Herttuala
Bacterial Vector in Gene Therapy, M.-S. Dai and G. Vassaux
Redox-Responsive Polymer-Based Gene Delivery Systems, D. Oupický, Y.-Z. You, and D.S. Manickam
Polymers and Dendrimers for Gene Delivery in Gene Therapy, I.F. Uchegbu, C. Dufès, P.L. Kan, and A.G. Schätzlein
Receptor-Targeted Polyplexes for DNA and siRNA Delivery, A. Philipp and E. Wagner
Electroporation of Plasmid-Based Vaccines and Therapeutics, R. Draghia-Akli and A.S. Khan
Magnetofection: Using Magnetic Particles and Magnetic Force to Enhance and to Target Nucleic Acid Delivery, F. Scherer and C. Plank
Biolistic and Other Needle-Free Delivery Systems, M.A.F. Kendall
Optimization of Nonviral Gene Therapeutics, N. Smyth Templeton
Photochemical Internalization: A Technology for Efficient and Site-Specifi c Gene Delivery, A. Bonsted, A. Høgset, and K. Berg
Interactions in Macromolecular Complexes Used as Nonviral Vectors for Gene Delivery, R. Podgornik, D. Harries, J. DeRouchey, H.H. Strey, and V.A. Parsegian
Other Therapeutic Strategies
In vivo Applications of Morpholino Oligonucleotides, J.S. Isenberg, W.A. Frazier, and D.D. Roberts
Antisense Oligonucleotide-Based Therapeutics, C.F. Bennett, E. Swayze, R. Geary, L. Tillman, and G. Hardee
Development of RNAi Therapeutics, A.R. de Fougerolles
Suicide Gene Therapy, N. Ballian, B.W. O’Malley Jr., and F.C. Brunicardi
Selectable Markers for Gene Therapy, J.-P. Gillet, C. Kimchi-Sarfaty, S. Shinar, T. Licht, C. Lee, P. Hafkemeyer, C.A. Hrycyna, I. Pastan, and M.M. Gottesman
Embryonic Stem Cells and Their Application in Regenerative Medicine and Tissue Engineering,.D. Evans and J.M. Polak
Polymeric Nano- and Microparticles for the Delivery of Antisense Oligonucleotides and siRNA, E. Fattal and G. De Rosa
Gene Expression and Detection
Deliberate Regulation of Therapeutic Transgenes, N. Vilaboa and R. Voellmy
Monitoring Gene and Cell Therapies in Living Subjects with Molecular Imaging Technologies, S. Ray, S. Biswal, and S.S. Gambhir
Nonviral Genome Modification Strategies for Gene Therapy: Transposon, Integrase,
and Homologous Recombination Systems, L.E. Woodard and M.P. Calos
Disease Targets and Therapeutic Strategies
Hematopoietic Progenitor Cells, K.-Y.K. Lin, O. Sirin, and M.A. Goodell
Gene Therapy for Hematopoietic Disorders,.M. Kang, M.E. Horwitz, and H.L. Malech
Use of Genetically Modified Stem Cells in Experimental Gene Therapies, T.P. Zwaka
Cardiovascular Gene and Cell Therapy, K. Oka
Gene Therapy for Cancer, K. Brand
Molecular Therapy for Type 1 and Type 2 Diabetes, S.L. Samson, V. Yechoor, and L. Chan
Progress toward Gene Therapy for Cystic Fibrosis, R.S. Everett and L.G. Johnson
Gene Therapy for Neurological Diseases, W.J. Bowers, S. de Silva, and H.J. Federoff
Principles of Gene Therapy for Inborn Errors of Metabolism, J.A. Wolff and C.O. Harding
RNA Interference–Based Gene Therapy Strategies for the Treatment of HIV Infection, L. Scherer and J.J. Rossi
Cutaneous Gene Transfer: Cell and Gene Therapy of Skin and Systemic Disorders, W. Buitrago and D.R. Roop
Gene Therapy for Childhood Onset Blindness, M.C. Canver and J. Bennett
DNA Vaccines, J. Yan and D.B. Weiner
Immunoisolation for CNS Cell Therapy, D.F. Emerich and C.G. Thanos
Clinical Trials and Regulatory Issues
Cardiovascular Gene Therapy, J. Tongers, J. Roncalli, and D.W. Losordo
Gene Therapy for the Treatment of Cancer: From Laboratory to Bedside, G. Dotti, B. Savoldo, F. Okur, R.F. Rousseau, and M.K. Brenner
p53 Tumor Suppressor Opens Gateways for Cancer Therapy, M.-S. Dai, J.R. Gallegos, and H. Lu
Recombinant Adenoviral-p53 Agent for Treatment of Cancers, Z. Peng, Q. Yu, and J. Zhu
Gene Marking Studies of Hematopoietic Cells, C.M. Bollard, S.K. Tey, M.K. Brenner, and H.E. Heslop
Regulatory Aspects of Gene Therapy, S.L. Simek and L. Bi

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