Gene Expression and Its Discontents: The Social Production of Chronic Disease / Edition 1

Gene Expression and Its Discontents: The Social Production of Chronic Disease / Edition 1

by Rodrick Wallace, Deborah Wallace
     
 

ISBN-10: 1441914811

ISBN-13: 9781441914811

Pub. Date: 11/17/2009

Publisher: Springer New York

Gene Expression and its Discontents examines a class of probability models describing how epigenetic context affects gene expression and organismal development, using the asymptotic limit theorems of information theory in a highly formal manner. Taking classic results on spontaneous symmetry breaking abducted from statistical physics in groupoid, rather than group,

Overview

Gene Expression and its Discontents examines a class of probability models describing how epigenetic context affects gene expression and organismal development, using the asymptotic limit theorems of information theory in a highly formal manner. Taking classic results on spontaneous symmetry breaking abducted from statistical physics in groupoid, rather than group, circumstances, the work suggests that epigenetic information sources act as analogs to a tunable catalyst, directing development into different characteristic pathways according to the structure of external signals. The results have significant implications for epigenetic epidemiology, in particular for understanding how environmental stressors, in a large sense, can induce a broad spectrum of developmental disorders in humans. The authors then apply the perspective to a number of chronic diseases broadly associated with obesity, using data at different scales of observation.

Product Details

ISBN-13:
9781441914811
Publisher:
Springer New York
Publication date:
11/17/2009
Edition description:
2010
Pages:
227
Product dimensions:
1.70(w) x 2.60(h) x 0.50(d)

Table of Contents

Models of development.- Groupoid symmetries.- Epigenetic catalysis.- Developmental disorders.- An interim perspective.- The obesity pandemic in the US.- Coronary heart disease in the US.- Cancer: a developmental perspective.- Autoimmune disorders.- Demoralization and obesity in Upper Manhattan.- Death at an early age: AIDS and related mortality in New York City.- Final thoughts.- Mathematical appendix.- References.

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