Gene Genealogies, Variation and Evolution: A Primer in Coalescent Theory

by Jotun Hein, Mikkel H. Schierup, Carsten Wiuf

Overview

Coalescent theory tells us what gene genealogies are expected to look like if populations have different demographic histories - i.e, population size, structure, etc. The aim of this book is to provide an accessible introduction to Coalescent Theory with a view towards data analysis. Coalescent Theory has in the last two decades moved from being an obscure technique that appealed to mathematical population geneticists to a central tool in data analysis of DNA sequences. The completion of the sequencing of the human genome and accompanying determination of SNPs and haplotypes will increase its importance even further. This textbook, rich in examples and illustrations, is suitable for a graduate course in statistics, population-, molecular-, and medical genetics.

Product Details

ISBN-13:	9780198529965
Publisher:	Oxford University Press
Publication date:	02/17/2005
Edition description:	New Edition
Pages:	296
Product dimensions:	9.72(w) x 6.78(h) x 0.62(d)

About the Author

University of Oxford

University of Aarhus

University of Aarhus

Table of Contents

1. The basic coalescent2. From genealogies to sequences3. Trees and topologies4. Extensions to the basic coalescent5. The coalescent with recombination6. Getting paramaters from data7. LD mapping and the coalescent8. Human evolution

Editorial Reviews

"There has been a dire need for a good book introducing coalescent theory to biologists. Gene Genealogies, Variation and Evolution fills this important gap this book should be mandatory reading for any graduate student working on population-level molecular data."-Evolution

From the Publisher