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Gene Regulation by Steroid Hormones IV
     

Gene Regulation by Steroid Hormones IV

by Arun K. Roy (Editor), James H. Clark (Editor)
 

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The first Meadowbrook Symposium was held in 1978 and during the intervening ten years our knowledge concerning how steroid hormones function at the level of gene expression has advanced by leaps and bounds. In this volume, which sum­ marizes our fourth meeting, these advances are very evident. What seemed like science fiction ten years ago has become commonplace

Overview

The first Meadowbrook Symposium was held in 1978 and during the intervening ten years our knowledge concerning how steroid hormones function at the level of gene expression has advanced by leaps and bounds. In this volume, which sum­ marizes our fourth meeting, these advances are very evident. What seemed like science fiction ten years ago has become commonplace science. Who would have imagined that we could synthesize a nucleotide sequence that binds a specific steroid receptor and acts as a controlling element for gene expression? No one; but as is evident from the results reported in several chapters, this technique is yielding a wealth of information. Using these and other techniques it has become apparent that gene transcription is controlled by interactions between transacting factors and DNA recognition sequences (response elements). These transacting factors appear to be members of a large gene family that includes steroid hormone receptors, transcription factors, protooncogenes and homeobox proteins. Thus a great deal has been learned, but as usual, questions remain. Many of these questions are posed by the findings and observations found in several chapters in this volume. Non­ hormone binding forms of steroid receptors and their relevance to receptor down regulation, recycling and biological response remain a mystery. The quantitative relationship between receptor binding and biological response still presents agonizing problems. These and many other intriguing questions are discussed in this volume and set the stage for what should be a most rewarding time in endocrinology. Winter 1989 ARUN K.

Editorial Reviews

Booknews
Proceedings of the 4th conference on hormones, held at Meadow Brook in 1988. Offers 14 papers on the latest findings in gene activation. Coverage includes: control of transcription by transacting factors, DNA recognition sequences, protooncogenes, receptor down regulation, and steroid response elements. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Product Details

ISBN-13:
9781461281979
Publisher:
Springer New York
Publication date:
07/31/2012
Edition description:
Softcover reprint of the original 1st ed. 1989
Pages:
239
Product dimensions:
6.10(w) x 9.25(h) x 0.02(d)

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