Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicineby Johnny Huard (Editor)
With the development of improved methods of transferring genes into cells, new treatment options are becoming available in orthopaedics and sports medicine to aid in the healing capacity of musculoskeletal tissues. In this book, current techniques in gene therapy and tissue engineering are described in addition to their potential applications in the management of orthopaedic trauma and sports-related injuries such as muscle injury and ligament, meniscus, or cartilage damage. The book bridges the gap between the clinicians aiming to improve recovery following such injuries, and researchers interested in tissue engineering and gene therapy. This book will be read by physicians and researchers in orthopaedic surgery, sports medicine, and cell and molecular biology.
Description: This is a comprehensive review of the research that has been conducted in the area of gene therapy and tissue engineering for treating orthopedic injuries.
Purpose: The primary purpose is to establish a common language to be used by research scientists and clinicians working in the area of orthopedic- and sports medicine-related soft tissue injuries. Secondary purposes are to describe the techniques presently used in gene therapy and tissue engineering, as well as their potential for improving future treatments and limitations that currently prevent their broad usage.
Audience: Written by highly respected experts, the authors intended this book to be read by research scientists and clinicians working in the area of orthopedic-related soft tissue injuries.
Features: The book covers the basic description of the processes involved in gene therapy and tissue engineering, a review of the research that has been conducted related to soft tissue injury, and applications to orthopedics and sports medicine. The current limitations of gene therapy and tissue engineering that prevent their broad practical usage and possible solutions to these problems are also presented. The thoroughness and objectivity of the reviewed literature is commendable. However, the use of black-and-white illustrations for histologic and anatomic material detracts from their intended purpose. Also, the title of the book is somewhat misleading in that there is currently limited practical use of these therapies. Most of the book focuses on description of animal experiments, with references to potential use in human applications.
Assessment: This well-written book should be considered by all who are interested in a thorough and comprehensive review of the research that has been conducted to improve tissue healing through gene therapy and tissue engineering, as well as those interested in learning about the potential that these therapies hold.
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