Gene Therapy for Cancer / Edition 1

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The possibility of treating cancer, a disease frequently defined by genetic defects, by introducing genes that target these very alterations has generated tremendous enthusiasm. This enthusiasm, however, has been tempered by an increasing number of obstacles to successful therapy, including vector systems that do not reach systemic metastases, therapeutic genes with redundant mechanisms allowing for cellular resistance, and toxicities in clinical trials that result in premature closure. The three comprehensive sections of this volume present currently available cancer gene therapy techniques, with specific attention to these trouble spots. Part I describes the various aspects of gene delivery including vehicles, or vectors, and their respective characteristics and production methods. In Part II, the contributors discuss strategies and targets for the treatment of cancer, including methods for cell-death therapies, correction of underlying genetic defects at the molecular level, and activation of the immune system or tumor microenvironment. The contributors provide a succinct framework for understanding the basic underlying oncogenic changes, which encourages the development of vectors engineered to exploit these gene mutations through selective spread of the vector in tumor cells with the specific changes. Finally, in Part III, experts in clinical gene therapy trials discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic, and principal investigators present gene therapy approache in the clinical testing stage and the results that have reached the stage of clinical testing of these trials. Vectors used in gene therapy for cancer, Characteristicsand production methods of cancer gene vectors, Targets and specific approaches for the therapy of cancer, Clinical applications of cancer gene therapy.
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Editorial Reviews

From the Publisher
From the reviews:

"The book is divided into 3 sections. … this book is informative and provides a comprehensive review of the advances and limitations of cancer gene therapy. … Overall, the book provides enjoyable and instructive reading material. I highly recommend this book to scientists as well as clinicians as a reference source for cancer gene therapy. Readers would benefit from this excellent reading material, whether they are relatively new to this subspecialty or are actively working within the field of cancer gene therapy." (Prem Seth, JAMA, Vol. 299 (11), 2008)

"Gene Therapy for Cancer … covers the current technologies of cancer gene therapy as well as the difficult task of applying these in clinical trials. … The book also benefits through its helpful tables, drawings and illustrations. … Gene Therapy for Cancer provides a good overview of currently available techniques for cancer gene therapy and their limitations and potential for clinical applications. The book is a useful addition to the library of both researchers and clinicians working in the field." (S. Schepelmann and C. J. Springer, British Journal of Cancer, Vol. 98 (3), 2008)

“This new volume in Humana’s series is written for oncologists, hematologists, cancer researchers, geneticists.” (Tumori, Vol. 93, 2007)

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Product Details

  • ISBN-13: 9781588294722
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 2/28/2007
  • Series: Cancer Drug Discovery and Development Series
  • Edition description: 2007
  • Edition number: 1
  • Pages: 469
  • Product dimensions: 7.40 (w) x 10.20 (h) x 0.90 (d)

Table of Contents

Preface     v
Contributors     ix
Adenovector-Mediated Cancer Gene Therapy   Bingliang Fang   Jack A. Roth     3
Efficacy, Toxicity, and Immunogenicity of Adenoviral Vectors   Dmitry M. Shayakhmetov     23
Lentiviral and Retroviral Vector Systems   Renata Stripecke   Noriyuki Kasahara     39
Vaccinia and Pox-Virus   Sricharan Chalikonda   David L. Bartlett     73
Herpes Simplex Virus as a Therapy for Cancer   Ian J. Mohr     87
Alphavirus Vectors for Gene Therapy Applications   Kenneth Lundstrom     109
Vesicular Stomatitis Virus and RNA Viruses as Gene Therapy Vectors   Glen N. Barber     121
Parvovirus Vectors   Selvarangan Ponnazhagan     141
Nonviral Vector Systems   Pui-yan Lee   Leaf Huang     157
Gene Therapy Approaches
Oncogenes, Tumor Suppressor Genes, and Apoptosis-Inducing Genes Utilized in Cancer Gene Therapy   Lidong Zhang   Bingliang Fang     173
Gene Silencing Therapy Against Cancer   Chao-Zhong Song     185
Tumor Targeting-Retargeted Adenovirus   Masato Yamamoto   David T. Curiel     197
Oncolytic HerpesSimplex for Gene Therapy in Preclinical and Clinical Trials   Richard H. Pin   Maura Reinblatt   Yuman Fong   William R. Jarnagin     213
Cytokine Gene Therapy for Genitourinary Cancer   Terry L. Timme   Tetsuo Fujita   Hongyu Wang   Koji Naruishi   Dov Kadmon   Robert J. Amato   Brian J. Miles   Gustavo Ayala   Thomas M. Wheeler   Bin S. Teh   E. Brian Butler   Timothy C. Thompson     223
Combination of Gene Therapy with Radiation   Anupama Munshi   Raymond E. Meyn     243
Gene Transfer for Chemoprotection and Enrichment of Hematopoietic Stem Cells   Justin C. Roth   Stanton L. Gerson     257
Nonviral Genetic Vaccines for Cancer   Steven R. Little   Daniel G. Anderson   Robert Langer     281
Gene Therapy Targeted at Angiogenesis and Lymphangiogenesis for Cancer Treatment   Anita T. Tandle   Steven K. Libutti     301
Tumor-Specific Replicating Adenoviruses: [Delta] 24 for Human Gliomas   Giacomo G. Vecil   Juan Fueyo   Frederick F. Lang     331
Clinical Applications
Problems, Side Effects, and Disappointments in Clinical Cancer Gene Therapy   Ta-Chiang Liu    David H. Kirn     351
Trials and Tribulations in Developing Clinical Trials of Gene Therapy: E1A for Breast or Ovarian Cancer   Naoto T. Ueno   Judith K. Wolf   David M. Gershenson   Gabriel N. Hortobagyi   Mien-Chie Hung     387
Phase I Clinical Experience with Intravenous Administration of PV701, an Oncolytic Virus   Andrew L. Pecora   Robert M. Lorence     399
MDA-7/IL-24 as a Multi-Modality Therapy for Cancer   Sunil Chada   Dora Bocangel   Abujiang Pataer   Abner M. Mhashilkar   Satoshi Inoue   Ryo Miyahara   Jack A. Roth   Elizabeth A. Grimm   Stephen G. Swisher   Kelly K. Hunt   Rajagopal Ramesh     413
Development of Therapeutic Genes for Breast Cancer Treatment   Mien-Chie Hung   Duen-Hwa Yan     435
Steps in a Translational Cancer Gene Therapy Trial   Urs W. von Holzen   Stephen G. Swisher     447
Index     461
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