Gene Therapy for Cancer / Edition 1

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The possibility of treating cancer, a disease frequently defined by genetic defects, by introducing genes that target these very alterations has generated tremendous enthusiasm. This enthusiasm, however, has been tempered by an increasing number of obstacles to successful therapy, including vector systems that do not reach systemic metastases, therapeutic genes with redundant mechanisms allowing for cellular resistance, and toxicities in clinical trials that result in premature closure. The three comprehensive sections of this volume present currently available cancer gene therapy techniques, with specific attention to these trouble spots. Part I describes the various aspects of gene delivery including vehicles, or vectors, and their respective characteristics and production methods. In Part II, the contributors discuss strategies and targets for the treatment of cancer, including methods for cell-death therapies, correction of underlying genetic defects at the molecular level, and activation of the immune system or tumor microenvironment. The contributors provide a succinct framework for understanding the basic underlying oncogenic changes, which encourages the development of vectors engineered to exploit these gene mutations through selective spread of the vector in tumor cells with the specific changes. Finally, in Part III, experts in clinical gene therapy trials discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic, and principal investigators present gene therapy approache in the clinical testing stage and the results that have reached the stage of clinical testing of these trials. Vectors used in gene therapy for cancer, Characteristicsand production methods of cancer gene vectors, Targets and specific approaches for the therapy of cancer, Clinical applications of cancer gene therapy.
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Editorial Reviews

From the Publisher
From the reviews:

"The book is divided into 3 sections. … this book is informative and provides a comprehensive review of the advances and limitations of cancer gene therapy. … Overall, the book provides enjoyable and instructive reading material. I highly recommend this book to scientists as well as clinicians as a reference source for cancer gene therapy. Readers would benefit from this excellent reading material, whether they are relatively new to this subspecialty or are actively working within the field of cancer gene therapy." (Prem Seth, JAMA, Vol. 299 (11), 2008)

"Gene Therapy for Cancer … covers the current technologies of cancer gene therapy as well as the difficult task of applying these in clinical trials. … The book also benefits through its helpful tables, drawings and illustrations. … Gene Therapy for Cancer provides a good overview of currently available techniques for cancer gene therapy and their limitations and potential for clinical applications. The book is a useful addition to the library of both researchers and clinicians working in the field." (S. Schepelmann and C. J. Springer, British Journal of Cancer, Vol. 98 (3), 2008)

“This new volume in Humana’s series is written for oncologists, hematologists, cancer researchers, geneticists.” (Tumori, Vol. 93, 2007)

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Product Details

  • ISBN-13: 9781617375903
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 12/9/2010
  • Series: Cancer Drug Discovery and Development Series
  • Edition description: Softcover reprint of hardcover 1st ed. 2007
  • Edition number: 1
  • Pages: 469
  • Product dimensions: 0.97 (w) x 10.00 (h) x 7.00 (d)

Table of Contents

Table of Contents



- Kelly K. Hunt, M.D. and Stephan A. Vorburger, M.D., M.C.R.


1. Adenovector-mediated Cancer Gene Therapy

- Bingliang Fang, M.D., Ph.D. and Jack A. Roth, M.D.

2. Efficacy, Toxicity and Immunogenicity of Adenoviral vectors

- Dmitry Shayakhmetov, Ph.D.

3. Lentiviral and Retroviral Vector Systems

- Renata Stripecke and Noriyuki Kasahara, M.D., Ph.D.

4. Vaccinia and Pox-Virus

- Sricharan Chalikonda, M.D. and David L. Bartlett, M.D.

5. Spinning Straw into Gold: The Potential of Replicating Herpes Simplex Virus as a Therapy for Cancer revealed by Genetic Alchemy

- Ian J. Mohr, Ph.D.

6. Alphavirus Vectors for Gene Therapy Applications

- Kenneth Lundstrom, Ph.D.

7. Vesicular Stomatitis Virus and RNA Viruses as Gene Therapy Vectors

- Glen N. Barber, Ph.D.

8. Parvovirus Vectors

- Selvarangan Ponnazhagan, Ph.D.

9. Non-Viral Vector Systems

- Pui-yan Lee and Leaf Huang, Ph.D.

Gene Therapy Approaches

10. Oncogenes, Tumor Suppressor Genes, and Apoptosis-Inducing Genes Utilized in Cancer Gene Therapy

- Lidong Zhang and Bingliang Fang, M.D., Ph.D.

11. Gene Silencing Therapy against Cancer

- Chao-Zhong Song, M.D., Ph.D.

12. Tumor Targeting-Retargeted Adenovirus

- Masato Yamamoto, M.D., Ph.D. and David T. Curiel, M.D., Ph.D.

13. Herpes Simplex Mediated Gene Therapy: Preclinical and and Clinical Approaches

- Richard H. Pin, Maura Reinblatt, Yuman Fong, and William R. Jarnagin, M.D.

14. Cytokine Gene Therapy for Genitourinary Cancer

- Terry L. Timme, Tetsuo Fujita, Hongyu Wang, Koji Naruishi, Dov Kadmon, Robert J. Amato, Brian J. Miles, Gustavo Ayala, Thomas M. Wheeler, Bin S. Teh, E. Brian Butler and Timothy C. Thompson, Ph.D.

15. Combination of Gene Therapy with Radiation

- Anupama Munshi, Ph.D. and Raymond E. Meyn, Ph.D.

16. Gene Transfer into Hematopoietic Stem Cells for Chemoprotection and in vivo Selection

- Justin C. Roth and Stanton L. Gerson, M.D.

17. Non-Viral Genetic Vaccines for Cancer

- Steven R. Little, Daniel G. Anderson Ph.D., and Robert Langer, Sc.D.

18. Gene Therapy Targeted at Angiogenesis and Lymphangiogenesis for Cancer Treatment

- Anita T. Tandle, Ph.D. and Steven K. Libutti, M.D.

19. Tumor-Specific Replicating Adenoviruses: Delta 24 for Human Gliomas

- Giacomo G. Vecil, M.D., Juan Fueyo, M.D., and Frederick F. Lang, M.D.

Clinical Applications

20. Problems, Side Effects and Disappointments in Clinical Cancer Gene Therapy

- Ta-Chiang Liu and David H. Kirn, M.D.

21. Trials and Tribulations in Developing Clinical Trials of Gene Therapy: E1A for Breast or Ovarian Cancer

- Naoto Ueno, M.D., Ph.D., Judith K. Wolf, M.D., David M. Gershenson, M.D., Gabriel N. Hortobagyi, M.D., and Mien-Chie Hung, Ph.D.

22. Phase I Clinical Experience with Intravenous Administration of PV701, an Oncolytic Virus

- Andrew L. Pecora, M.D. and Robert M. Lorence

23. MDA-7/IL-24 as a Multi-Modality Therapy for Cancer

- Sunil Chada, Ph.D., Dora Bocangel, Abujiang Pataer, Abner M. Mhashilkar, Satoshi Inoue, Ryo Miyahara, Jack A. Roth, Elizabeth A. Grimm, Stephen G. Swisher, M.D., Kelly K. Hunt, M.D. and Rajagopal Ramesh, Ph.D.

24. Development of Therapeutic Genes for Breast Cancer Treatment

- Mien-Chie Hung, Ph.D. and Duen-Hwa Yan, Ph.D.

25. Steps in a Translational Cancer Gene Therapy Trial

- Urs W. von Holzen, M.D. and Stephen G. Swisher, M.D.

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