Gene Therapy: Therapeutic Mechanisms And Strategies / Edition 1

Gene Therapy: Therapeutic Mechanisms And Strategies / Edition 1

by Nancy Smyth Templeton
     
 

ISBN-10: 0824776658

ISBN-13: 9780824776657

Pub. Date: 06/15/2000

Publisher: Taylor & Francis

This up-to-date, comprehensive reference/text covers all aspects of gene therapy, including basic principles, viral and nonviral delivery systems, targeted diseases, regulatory issues, and FDA requirements.

Investigates genetic bullets to block HIV-1 replication and genetic guns to deliver antiviral agents! Including over 4000 references, drawings, micrographs,

Overview

This up-to-date, comprehensive reference/text covers all aspects of gene therapy, including basic principles, viral and nonviral delivery systems, targeted diseases, regulatory issues, and FDA requirements.

Investigates genetic bullets to block HIV-1 replication and genetic guns to deliver antiviral agents! Including over 4000 references, drawings, micrographs, tables, and equations, and contributions from nearly 80 international experts, Gene Therapy examines:

  • donor cells, vector systems, and functional genes
  • defines extra- and intracellular pathways and barriers for gene delivery
  • details the advantages of myoblasts and RetroTet vectors
  • addresses the interaction of micelles and liposomes with nucleic acids
  • � describes the formulations, pharmacology, and toxicology of oligonucleotides
  • considers RNA catalysis and decoy RNAs
  • outlines hematopoietic stem cell procurement
  • reveals strategies to circumvent barriers to airway gene transfer
  • discusses the bystander effect � and much more!
Offering perspective on how to choose the most responsive pathologies, Gene Therapy is a cutting-edge reference for biochemists, geneticists, hematologists, oncologists, molecular and cell biologists, virologists, and immunologists, and an excellent text for medical school and graduate students in these disciplines.

Product Details

ISBN-13:
9780824776657
Publisher:
Taylor & Francis
Publication date:
06/15/2000
Pages:
608
Product dimensions:
8.40(w) x 11.00(h) x 1.20(d)

Related Subjects

Table of Contents

Forewordv
Prefacevii
Contributorsxi
Part I.Viral Delivery and Therapeutic Strategies
1.Retroviral Vectors for Gene Therapy1
2.Adenovirus Vectors for Gene Therapy17
3.Adeno-Associated Virus and Adeno-Associated Virus Vectors for Gene Delivery41
4.Ex Vivo Gene Therapy Using Myoblasts and Regulatable Retroviral Vectors61
5.Design and Use of Herpes Simplex Viral Vectors for Gene Therapy81
6.Alphavirus-Based Vectors for Vaccine and Gene Therapy Applications109
Part IINonviral Delivery and Therapeutic Strategies
7.Gene Delivery with Polyethylenimine131
8.Receptor-Mediated Gene Transfer141
9.Modification of Melanoma Cells via Ballistic Gene Delivery for Vaccination165
10.Polymer-Encapsulated Cells for Gene Therapy181
11.Molecular Interactions in Lipids, DNA, and DNA-Lipid Complexes209
12.Bioorganic Colloids: Macromolecules, DNA, Self-Assembled Particles, and Their Complexes241
13.Synthetic Virus Systems for Systemic Gene Therapy267
Part III.Other Therapeutic Strategies and Regulatory Aspects
14.Gene Therapy Applications of Ribozymes291
15.Antisense Oligonucleotide-Based Therapeutics305
16.Selectable Markers for Gene Therapy333
17.Suicide Gene Therapy353
18.Regulatory Aspects of Gene Therapy371
Part IV.Disease Targets and Therapeutic Strategies
19.Gene Transfer into Hematopoietic Stem Cells383
20.Gene Therapy for Hematopoietic Disorders405
21.Gene Therapy for Cardiovascular Disease and Vascular Grafts421
22.Gene Therapy for Cancer439
23.Barriers to Efficient Airway Epithelial Gene Transfer: Lessons from Cystic Fibrosis473
24.Gene Transfer to the Central Nervous System489
25.Principles of Gene Therapy for Inborn Errors of Metabolism507
26.Gene Therapy and HIV-1 Infection519
27.Gene Delivery to the Skin535
28.DNA Vaccines549
Index569

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