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Gene Therapy of Cancer: Methods and Protocols / Edition 2
     

Gene Therapy of Cancer: Methods and Protocols / Edition 2

by Wolfgang Walther, Ulrike S. Stein
 

ISBN-10: 1934115851

ISBN-13: 9781934115855

Pub. Date: 04/28/2009

Publisher: Springer-Verlag New York, LLC

Despite various difficulties, the field of gene therapy, particularly with regard to cancer, has accumulated a tremendous amount of vital pre-clinical and clinical data. Gene Therapy of Cancer: Methods and Protocols Second Edition fully updates the first edition with expert coverage of established and novel protocols involving both experimental and clinical

Overview

Despite various difficulties, the field of gene therapy, particularly with regard to cancer, has accumulated a tremendous amount of vital pre-clinical and clinical data. Gene Therapy of Cancer: Methods and Protocols Second Edition fully updates the first edition with expert coverage of established and novel protocols involving both experimental and clinical approaches to cancer-gene therapy. This state-of-the-art volume contains overviews of new concepts and strategies with chapters on regulatory and ethical issues, developments, problems and possible limitations of design and production of gene therapeutics as well as translational issues. Written in the highly successful Methods in Molecular Biology" series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Cutting edge and authoritative, Gene Therapy of Cancer: Methods and Protocols, Second Edition is an ideal guide for all those who wish to explore the fast-paced and critical study of non viral, viral, experimental and clinical cancer gene therapy.

Product Details

ISBN-13:
9781934115855
Publisher:
Springer-Verlag New York, LLC
Publication date:
04/28/2009
Series:
Methods in Molecular Biology Series , #542
Edition description:
2nd ed. 2009
Pages:
738
Product dimensions:
7.60(w) x 10.30(h) x 1.60(d)

Table of Contents

Preface v

Contributors xi

Section I Experimental Approaches in Cancer Therapy

Subsection A Introduction

1 The Development of Gene Therapy: From Monogenic Recessive Disorders to Complex Diseases Such as Cancer Jean-Pierre Gillet Benjamin Macadangdang Robert L. Fathke Michael M. Gottesman Chava Kimchi-Sarfaty

Subsection B Vectorology For Cancer Gene Therapy

2 Designing Adenoviral Vectors for Tumor-Specific Targeting Ramon Alemany 57

3 Analysis of HSV Oncolytic Virotherapy in Organotypic Cultures Giulia Fulci Brent Passer 75

4 Use of Minicircle Plasmids for Gene Therapy Peter Mayrhofer Martin Schleef Wolfgang Jechlinger 87

5 Transposable Elements as Plasmid-Based Vectors for Long-Term Gene Transfer into Tumors John R. Ohlfest Zoltán Ivics Zsuzsanna Izsvák 105

6 Designing Plasmid Vectors Oleg Tolmachov 117

7 Development of Bacterial Vectors for Tumor-Targeted Gene Therapy Li-Jun Jia Zi-Chun Hua 131

Subsection C Nonviral Transfer Technologies in Cancer Gene Therapy

8 Electroporative Gene Transfer Marco Schmeer 157

9 Gene Gun Delivery Systems for Cancer Vaccine Approaches Kandan Aravindaram Ning Sun Yang 167

10 Ultrasound-Mediated Gene Transfection Loreto B. Feril Jr. 179

11 Nonviral Jet-Injection Technology for Intratumoral In Vivo Gene Transfer of Naked DNA Wolfgang Walther Iduna Fichtner Peter M. Schlag Ulrike S. Stein 195

Subsection D Experimental Studies In Cancer Gene Therapy

12 Methods for Constructing and Evaluating Antitumor DNA Vaccines Brian M. Olson Douglas G. McNeel 211

13 Immunity of Lentiviral Vector-Modified Dendritic Cells Shuhong Han Lung-Ji Chang 245

14 Saporin Suicide Gene Therapy Natasa Zarovni Riccardo Vago MariaSerena Fabbrini 261

15 Using In Vivo Biopanning for the Development of Radiation-Guided Drug Delivery Systems Jerry J. Jaboin Zhaozhong Han Dennis E. Hallahan 285

16 Chemosensitization of Tumor Cells: Inactivation of Nuclear Factor-Kappa B Associated with Chemosensitivity in Mealanoma Cels After Combination Treatment with E2F-1 and Doxorubicin Hongying Hao H. Sam Zhou Kelly M. McMasters 301

17 Induction of Tumor Cell Apoptosis by TRAIL Gene Therapy Thomas S. Griffith 315

18 Silencing Epidermal Growth Factor Receptor by RNA Interference in Glioma Chunsheng Kang Peiyu Pu Hao Jiang 335

19 Delivery of Phosphorodiamidate Morpholino Antisense Oligomers in Cancer Cells Gayathri R. Devi 351

20 Use of RNA Aptamers for the Modulation of Cancer Cell Signaling Sunjoo Jeong Hee Kyu Lee Mee Young Kim 363

21 G-Rich Oligonucleotides for Cancer Treatment Paula J. Bates Enid W. Choi Lalitha V. Nayak 379

Section II Clinical Approaches in Cancer Gene Therapy

Subsection A Requirements for Clinical Gene Therapy Trials

22 Regulatory Aspects for Translating Gene Therapy Research into the Clinic Carolyn M. Laurencot Sheryl Ruppel 397

23 Ethics of Cancer Gene Transfer Clinical Research Jonathan Kimmelman 423

24 Virus Production for Clinical Gene Therapy Tiago Vicente Cristina Peixoto Manuel J.T. Carrondo Paula M. Alves 447

25 Production of Plasmid DNA as Pharmaceutical Martin Schleef Markus Blaesen 471

Subsection B Clinical Protocols in Cancer Gene Therapy

26 Gene Immunotherapy for Non-Small Cell Lung Cancer John J. Nemunaitis 499

27 Gene Therapy for Antitumor Vaccination Seunghee Kim-Schulze Howard L. Kaufman 515

28 HSV-tk/IL-2 Gene Therapy for Glioblastoma Multiforme Luisa Barzon Monia Pacenti Elisa Franchin Federico Colombo Giorgio Palú 529

29 Construction and Characterization of an Oncolytic HSV Vector Containing a Fusogenic Glycoprotein and Prodrug Activation for Enhanced Local Tumor Control Guy R. Simpson Robert S. Coffin 551

30 Newcastle Disease Virus: A Promising Vector for Viral Therapy, Immune Therapy, and Gene Therapy of Cancer Volker Schirrmacher Philippe Fournier 565

31 Oncolytic Viral Therapy Using Reovirus Chandini Thirukkumaran Don G. Morris 607

32 Design and Testing of Novel Oncolytic Vaccinia Strains Steve H. Thorne 635

33 Tumor-Targeted Salmonella typhimurium Overexpressing Cytosine Deaminase: A Novel, Tumor-Selective Therapy Ivan King Martina Itterson David Bermudes 649

34 Chemoprotection by Transfer of Resistance Genes Tulin Budak-Alpdogan Joseph R. Bertino 661

35 Phase I Clinical Trial of Locoregional Administration of the Oncolytic Adenovirus ONYX-015 in Combination with Mitomycin-C, Doxorubicin, and Cisplatin Chemotherapy in Patients with Advanced Sarcomas Mateusz Opyrchal Ileana Aderca Evanthia Galanis 705

Index 719

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