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Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications / Edition 1

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Overview

The use of gene transfer as a potential therapeutic approach represents a rapidly emerging field of basic and applied medical research that has recently begun to mature into initial clinical trials for a substantial variety of inherited as well as acquired diseases. The diseases which are being evaluated as potential targets for therapeutic approaches involving the use of genetic material encompass illnesses typically treated within a wide range of medical specialties. The field of cardiovascular medicine is no exception to this.
The purpose of this book is to help those involved, considering involvement, or merely interested in the various aspects of gene transfer as it is being developed for the tissues of the cardiovascular system.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Allen Mark Samarel, MD (Loyola University Stritch School of Medicine)
Description: This is multiauthored monograph contains contributions by experts in the field of cardiovascular gene therapy. The editor, Dr. Keith March, a well-respected cardiovascular scientist in this rapidly developing field, has done an outstanding job of integrating into a unique book contributions from a very diverse group of writers.
Purpose: The overall goal is to incorporate recent information from the entire spectrum of the discipline into a single source.
Audience: According to the editor, the book is intended to be a helpful resource to cardiovascular scientists and molecular biologists involved in or interested in the field of gene transfer in the cardiovascular system.
Features: The book is divided into six parts, containing a total of 21 chapters, and features contributions by academic and industry leaders. To expedite publishing, the book was prepared as camera-ready copy, but it is remarkably easy to read. Despite this fact, references appear to be somewhat dated (only up to 1994 in some chapters). Most chapters are appropriately illustrated with useful black-and-white figures and schematics. Several color plates precede a well-organized index, and there are numerous cross-references within individual chapters to improve readability of this multiauthored work. The overall appearance of the book is very good. It provides a thoughtful overview of a complex subject that offers great promise.
Assessment: The book is an excellent addition to any cardiovascular scientist's library, and it should be a useful resource for those in this rapidly growing field.
From The Critics
Reviewer: Allen Mark Samarel, MD(Loyola University Stritch School of Medicine)
Description: This is multiauthored monograph contains contributions by experts in the field of cardiovascular gene therapy. The editor, Dr. Keith March, a well-respected cardiovascular scientist in this rapidly developing field, has done an outstanding job of integrating into a unique book contributions from a very diverse group of writers.
Purpose: The overall goal is to incorporate recent information from the entire spectrum of the discipline into a single source.
Audience: According to the editor, the book is intended to be a helpful resource to cardiovascular scientists and molecular biologists involved in or interested in the field of gene transfer in the cardiovascular system.
Features: The book is divided into six parts, containing a total of 21 chapters, and features contributions by academic and industry leaders. To expedite publishing, the book was prepared as camera-ready copy, but it is remarkably easy to read. Despite this fact, references appear to be somewhat dated (only up to 1994 in some chapters). Most chapters are appropriately illustrated with useful black-and-white figures and schematics. Several color plates precede a well-organized index, and there are numerous cross-references within individual chapters to improve readability of this multiauthored work. The overall appearance of the book is very good. It provides a thoughtful overview of a complex subject that offers great promise.
Assessment: The book is an excellent addition to any cardiovascular scientist's library, and it should be a useful resource for those in this rapidly growing field.
Allen M. Samarel
This is multiauthored monograph contains contributions by experts in the field of cardiovascular gene therapy. The editor, Dr. Keith March, a well-respected cardiovascular scientist in this rapidly developing field, has done an outstanding job of integrating into a unique book contributions from a very diverse group of writers. The overall goal is to incorporate recent information from the entire spectrum of the discipline into a single source. According to the editor, the book is intended to be a helpful resource to cardiovascular scientists and molecular biologists involved in or interested in the field of gene transfer in the cardiovascular system. The book is divided into six parts, containing a total of 21 chapters, and features contributions by academic and industry leaders. To expedite publishing, the book was prepared as camera-ready copy, but it is remarkably easy to read. Despite this fact, references appear to be somewhat dated (only up to 1994 in some chapters). Most chapters are appropriately illustrated with useful black-and-white figures and schematics. Several color plates precede a well-organized index, and there are numerous cross-references within individual chapters to improve readability of this multiauthored work. The overall appearance of the book is very good. It provides a thoughtful overview of a complex subject that offers great promise. The book is an excellent addition to any cardiovascular scientist's library, and it should be a useful resource for those in this rapidly growing field.
Booknews
Twenty-one contributions discuss the molecular vectors that are being developed for many therapeutic applications; the issues surrounding techniques for achieving local delivery of genetic as well as standard pharmaceutical agents specific for vascular targets; studies relating to local gene transfer to regions of the vessel wall or myocardium; the range of genetic approaches directed towards cardiovascular targets which could function by systemic rather than local expression of desired genes; and issues involved in the interaction between the physics of delivery modalities and the properties of vectors and tissue targets. Annotation c. by Book News, Inc., Portland, Or.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780792398592
  • Publisher: Springer US
  • Publication date: 3/28/1997
  • Series: Developments in Cardiovascular Medicine Series , #189
  • Edition description: 1997
  • Edition number: 1
  • Pages: 516
  • Product dimensions: 6.14 (w) x 9.21 (h) x 1.25 (d)

Table of Contents

Preface: Molecular and Mechanical Aspects of Gene Transfer; K.L. March. Acknowledgements. Vectors and Gene Transfer Systems: Molecular Aspects of Delivery. 1. Development of Viral Vectors for Human Gene Therapy; Retrovirus and Adenovirus (Part I); B.C. Trapnell, M.N. Pensiero. 2. Adenoviruses (Part II): Improvement of Adenoviral Vectors for Human Gene Therapy: E1 and E4 Deleted Recombinant Adenoviruses; J.F. Dedieu, et al. 3. Adeno-Associated Virus and Other New DNA Virus Vectors; T.R. Floote, et al. 4. Plasmid and Other Non-Viral Vectors; L.B. Jacobsen. 5. The HVJ/Liposome Molecular Delivery System for In Vivo Genetic Engineering; G.H. Gibbons. 6. Endogenous Expression Modification: Antisense Approaches; M. Simons. Methods for Localizing Gene Transfer: Mechanical Aspects of Delivery. 7. Catheter-Based Local Drug and Gene Delivery; R.L. Wilensky. 8. Fluid Dynamics of Catheter Delivery: Effects on Delivery Efficiency and Localization; C.R. Lambert, S. Rowland. 9. Targeted and Sustained-Release Delivery Concepts in Gene Therapy; R.W. Schroff, L.L. Kunz. Gene Delivery For Local Vascular Expression. 10. Viral Vector-Based Vascular Gene Delivery: Basic Studies and Therapeutic Applications; E.G. Nabel. 11. Cell-Based Vascular Gene Delivery: Endothelial Cells as Carriers; J. Burke, et al. 12. Cell-Based Gene Delivery: Smooth Muscle Cells as Carriers; A.W. Clowes. 13. Vascular Cell Proliferation Dynamics: Implications for Gene Transfer and Restenosis; R.S. Schwartz, et al.14. Angiogenesis and Collateral Formation; J.M. Isner. Gene Delivery for Local Cardiac Expression. 15. Cell-Based Myocardial Protein Delivery; M.H. Soonpaa, L.J. Field. 16. Skeletal Myoblast Therapy in Cardiovascular Disease; D.A. Taylor, et al. 17. Adenovirus and the Myocardium; J.A. Towbin. Gene Delivery for Systemic Expression. 18. Gene Delivery for Systemic Expression: Plasmid, Retroviral, and Adenoviral Approaches; K. Parker Ponder. 19. Adenoviral Gene Delivery Approaches for Systemic Expression; S.C. Stevenson, A. McClelland. 20. Experimental Approaches Using Kallikrein Gene Therapy for Hypertension; J. Chao, L. Chao. Biophysical Considerations in Vector Delivery. 21. Pharmacokinetics of Local Vector Delivery to Vascular Tissues: Implications for Efficiency and Localization; K.L. March, B. Trapnell. Color Plates. Index.

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