Genes and Signals / Edition 1

Paperback (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $3.14
Usually ships in 1-2 business days
(Save 91%)
Other sellers (Paperback)
  • All (10) from $3.14   
  • New (2) from $65.00   
  • Used (8) from $3.14   
Sort by
Page 1 of 1
Showing All
Note: Marketplace items are not eligible for any coupons and promotions
Seller since 2014

Feedback rating:



New — never opened or used in original packaging.

Like New — packaging may have been opened. A "Like New" item is suitable to give as a gift.

Very Good — may have minor signs of wear on packaging but item works perfectly and has no damage.

Good — item is in good condition but packaging may have signs of shelf wear/aging or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Acceptable — item is in working order but may show signs of wear such as scratches or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Used — An item that has been opened and may show signs of wear. All specific defects should be noted in the Comments section associated with each item.

Refurbished — A used item that has been renewed or updated and verified to be in proper working condition. Not necessarily completed by the original manufacturer.

Brand new.

Ships from: acton, MA

Usually ships in 1-2 business days

  • Standard, 48 States
  • Standard (AK, HI)
Seller since 2014

Feedback rating:


Condition: New
Brand new.

Ships from: acton, MA

Usually ships in 1-2 business days

  • Standard, 48 States
  • Standard (AK, HI)
Page 1 of 1
Showing All
Sort by


Genes & Signals analyzes gene regulation from a new perspective. The first chapter describes mechanisms found in bacteria, and two subsequent chapters discuss which of these is most highly exploited in higher organisms. A final chapter relates these molecular strategies to other enzymatic processes, including those involving kinases, RNA splicing enzymes, proteases, and others. A general theme emerges, one that proposes how a rather restricted set of signals and enzymatic functions has been used in evolution to generate complex life forms of different types.
Read More Show Less

Editorial Reviews

In Genes & Signals, Ptashne and Gann have written a unique book that is driven by ideas and broad concepts, yet is based on solid information. It is accessible to undergraduates with some knowledge of biology, yet it is also valuable to experts in the field. I highly recommend it.
Nature Genetics
A compelling and deeply conceptual work about how biological reactions are regulated. . . . What this book provides is a guide to the concepts that form the framework for the gene expression field. The concepts allow students to understand the context of the facts and apply this information to their own studies. Students who are lucky enough to read Genes & Signals won't be slithering out of transcription seminars in 30 years, when our field has been condensed to an in silico version of an intermediary metabolism wall chart.
From The Critics
Ptashne (Memorial Sloan-Kettering Cancer Center) and Gann (Cold Spring Harbor Laboratory, New York) introduce readers to general principles of how genes are controlled—how genes are expressed, or not, in response to environmental signals—and examine ways that molecular mechanisms underlying gene expression apply to many other biological regulatory processes. Specific chapter coverage includes mechanisms found in bacteria, which of these is mostly highly exploited in higher organisms, and how this molecular strategy relates to other enzymatic processes, including those involving kinases, RNA splicing enzymes, proteases, and others. Academic, but accessible to readers who have had a basic introduction to molecular biology. Annotation c. Book News, Inc., Portland, OR (
Read More Show Less

Product Details

  • ISBN-13: 9780879696337
  • Publisher: Cold Spring Harbor Laboratory Press
  • Publication date: 12/11/2001
  • Series: Textbook Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 192
  • Product dimensions: 6.10 (w) x 8.88 (h) x 0.52 (d)

Table of Contents




Chapter 1 - Lessons from Bacteria
RNA Polymerase
Regulated Recruitment: The lac genes
More Regulated Recruitment: The Bacteriophage l
Panel: Antitermination: N and Q
Polymerase Activation: glnA and Related Genes
PANEL: Phage T4 Late Genes
Promoter Activation: merT and Related Genes
General Summary
PANEL: More on Repression in Bacteria

Chapter 2 - Yeast: A Single-celled Eukaryote
RNA Polymerase
Other Parts of the Transcriptional Machinery
An Overview of Activation
A Model Case: The GAL Genes
How Gal4 Works
PANEL: Activator Bypass Experiments
Signal Integration and Combinatorial Control
PANEL: Variegation Visualized
PaneL: Epigenetics
DNA Looping

Chapter 3- Some Notes on Higher Eukaryotes
Mechanism of Activation: Recruitment
What Is Recruited?
Detecting and Transmitting Physiological Signals
Panel: Transport-dependent Proteolysis: The Case of SREBP
Signal Integration, Combinatorial Control, and Alternative Enhancers
Action at a Distance
DNA Methylation, Insulators, and Imprinting
Chromosomal Position and Gene Expression

Chapter 4 - Enzyme Specificity and Regulation
Ubiquitylation and Proteolysis
Imposing Specificity on Kinases
Interim Summary and Extensions
Further Generalizations


Appendix 1: More on Cooperativity
Appendix 2: Topogenic Sequences
Appendix 3: All-or-none Effects and Levels of Gene Expression


Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)