Genes and Signals / Edition 1

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Overview

Genes & Signals analyzes gene regulation from a new perspective. The first chapter describes mechanisms found in bacteria, and two subsequent chapters discuss which of these is most highly exploited in higher organisms. A final chapter relates these molecular strategies to other enzymatic processes, including those involving kinases, RNA splicing enzymes, proteases, and others. A general theme emerges, one that proposes how a rather restricted set of signals and enzymatic functions has been used in evolution to generate complex life forms of different types.
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Editorial Reviews

Nature
In Genes & Signals, Ptashne and Gann have written a unique book that is driven by ideas and broad concepts, yet is based on solid information. It is accessible to undergraduates with some knowledge of biology, yet it is also valuable to experts in the field. I highly recommend it.
Nature Genetics
A compelling and deeply conceptual work about how biological reactions are regulated. . . . What this book provides is a guide to the concepts that form the framework for the gene expression field. The concepts allow students to understand the context of the facts and apply this information to their own studies. Students who are lucky enough to read Genes & Signals won't be slithering out of transcription seminars in 30 years, when our field has been condensed to an in silico version of an intermediary metabolism wall chart.
From The Critics
Ptashne (Memorial Sloan-Kettering Cancer Center) and Gann (Cold Spring Harbor Laboratory, New York) introduce readers to general principles of how genes are controlled—how genes are expressed, or not, in response to environmental signals—and examine ways that molecular mechanisms underlying gene expression apply to many other biological regulatory processes. Specific chapter coverage includes mechanisms found in bacteria, which of these is mostly highly exploited in higher organisms, and how this molecular strategy relates to other enzymatic processes, including those involving kinases, RNA splicing enzymes, proteases, and others. Academic, but accessible to readers who have had a basic introduction to molecular biology. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780879696337
  • Publisher: Cold Spring Harbor Laboratory Press
  • Publication date: 12/11/2001
  • Series: Textbook Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 192
  • Product dimensions: 6.10 (w) x 8.88 (h) x 0.52 (d)

Table of Contents

Preface

Foreword

Introduction

Chapter 1 - Lessons from Bacteria
RNA Polymerase
Regulated Recruitment: The lac genes
More Regulated Recruitment: The Bacteriophage l
Panel: Antitermination: N and Q
Polymerase Activation: glnA and Related Genes
PANEL: Phage T4 Late Genes
Promoter Activation: merT and Related Genes
General Summary
PANEL: More on Repression in Bacteria
Footnotes
Bibliography

Chapter 2 - Yeast: A Single-celled Eukaryote
RNA Polymerase
Other Parts of the Transcriptional Machinery
An Overview of Activation
A Model Case: The GAL Genes
How Gal4 Works
PANEL: Activator Bypass Experiments
Signal Integration and Combinatorial Control
Silencing
PANEL: Variegation Visualized
PaneL: Epigenetics
DNA Looping
Summary
Footnotes
Bibliography

Chapter 3- Some Notes on Higher Eukaryotes
Mechanism of Activation: Recruitment
What Is Recruited?
Repression
Detecting and Transmitting Physiological Signals
Panel: Transport-dependent Proteolysis: The Case of SREBP
Signal Integration, Combinatorial Control, and Alternative Enhancers
Action at a Distance
DNA Methylation, Insulators, and Imprinting
Chromosomal Position and Gene Expression
Compartmentalization
Overview
Footnotes
Bibliography

Chapter 4 - Enzyme Specificity and Regulation
Ubiquitylation and Proteolysis
Splicing
Imposing Specificity on Kinases
Interim Summary and Extensions
Further Generalizations
Footnotes
Bibliography

Afterword

Appendices
Appendix 1: More on Cooperativity
Appendix 2: Topogenic Sequences
Appendix 3: All-or-none Effects and Levels of Gene Expression

Index

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