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Genes VIII / Edition 1

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Overview

Two decades ago Benjamin Lewin's Genes revolutionized the way we think about and teach molecular biology and molecular genetics. His approach unified the discipline by providing an integrated account of the structure and function of genes in both prokaryotes and eukaryotes.

Setting a standard for currency, Genes continually embraces emerging trends in this field, such as introducing the molecular aspect of the gene before the traditional analysis of formal genetics. Genes VIII continues to innovate; expanding the early discussion of the genome and integrating new information on gene sequencing throughout the text.

New Content
  • Human and mouse genome sequence data incorporated throughout
  • Integrated coverage of recent advances in genomics and gene organization
Updated Content
  • DNA replication, repair, and recombination
  • Transcription and translation
  • Cancer and signal transduction

Genes VIII includes access to an innovative Website featuring a complete E-book with Flash illustrations. The text will be continuously updated online, providing coverage of the most recent advances in the field. Links to primary research articles are available whenever possible. ()

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Product Details

  • ISBN-13: 9780131439818
  • Publisher: Pearson
  • Publication date: 12/28/2003
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 1056
  • Product dimensions: 8.48 (w) x 11.10 (h) x 1.49 (d)

Table of Contents

Pt. 1 Genes
1 Genes are DNA
2 The interrupted gene
3 The content of the genome
4 Clusters and repeats
Pt. 2 Proteins
5 Messenger RNA
6 Protein synthesis
7 Using the genetic code
8 Protein localization
Pt. 3 Gene expression
9 Transcription
10 The operon
11 Regulatory circuits
12 Phage strategies
Pt. 4 DNA
13 The replicon
14 DNA replication
15 Recombination and repair
16 Transposons
17 Retroviruses and retroposons
18 Rearrangement of DNA
Pt. 5 The Nucleus
19 Chromosomes
20 Nucleosomes
21 Promoters and enhancers
22 Activating transcription
23 Controlling chromatin structure
24 RNA splicing and processing
25 Catalytic RNA
26 Immune diversity
Pt. 6 Cells
27 Protein trafficking
28 Signal transduction
29 Cell cycle and growth regulation
30 Oncogenes and cancer
31 Gradients, cascades, and signaling pathways
Glossary
Index
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Preface

With this eighth edition of GENES, 20 years have passed since the first edition. A novel feature of that first edition was the a presentation of prokaryotic and eukaryotic work in the context of a unified approach. Such an approach has now become commonplace as a result of along string of discoveries showing similarities in solutions to arc'-biological problems that often extend across many or even all species.

This new edition has been extensively revised and reorganized. The two most striking driving forces for change have been the sequencing of many genomes, providing information that permeates many sections of the book, and the availability of crystal structures, which in many cases replaces speculations about mechanism with detailed views.

A major change in presentation is made possible by the advent of the internet. A continuously updated version of GENES is maintained at www.ergito.com. Aside from some obvious differences in presentation, which allow the reader to customize a variety of views, the web version cites references within the text (compared with at the end of each chapter in the print version), and of course the citations are hyperlinked to original source material wherever possible. A concordance allows readers to find the section of the web site that is equivalent to any print section of the book (or vice versa).

A word is in order about the choice of references. With widespread adoption of policies that allow free access to material after a reasonable delay, the advantages to the scientific community for transparency in access have been made abundantly clear. In these circumstances, I do not regard publications in journals thatneither adopt this policy nor are widely available (often because they are unreasonably expensive) as legitimate contributions to the scientific literature. I see no point in citing publications to which many readers will not have access. References are cited at the end of each chapter, organized by sections, and are classed into reviews (rev), research articles (ref), and accounts by authors of classic experiments on the ergito web site (exp).

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Introduction

With this eighth edition of GENES, 20 years have passed since the first edition. A novel feature of that first edition was the a presentation of prokaryotic and eukaryotic work in the context of a unified approach. Such an approach has now become commonplace as a result of along string of discoveries showing similarities in solutions to arc'-biological problems that often extend across many or even all species.

This new edition has been extensively revised and reorganized. The two most striking driving forces for change have been the sequencing of many genomes, providing information that permeates many sections of the book, and the availability of crystal structures, which in many cases replaces speculations about mechanism with detailed views.

A major change in presentation is made possible by the advent of the internet. A continuously updated version of GENES is maintained atergito.com. Aside from some obvious differences in presentation, which allow the reader to customize a variety of views, the web version cites references within the text (compared with at the end of each chapter in the print version), and of course the citations are hyperlinked to original source material wherever possible. A concordance allows readers to find the section of the web site that is equivalent to any print section of the book (or vice versa).

A word is in order about the choice of references. With widespread adoption of policies that allow free access to material after a reasonable delay, the advantages to the scientific community for transparency in access have been made abundantly clear. In these circumstances, I do not regard publications in journals that neither adoptthis policy nor are widely available (often because they are unreasonably expensive) as legitimate contributions to the scientific literature. I see no point in citing publications to which many readers will not have access. References are cited at the end of each chapter, organized by sections, and are classed into reviews (rev), research articles (ref), and accounts by authors of classic experiments on the ergito web site (exp).

Read More Show Less

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