Genetic Approaches to Mental Disorders / Edition 1

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Arlington, Virginia, U.S.A. 1994 Hardcover New 0880489510. FLAWLESS COPY, AVOID WEEKS OF DELAY ELSEWHERE. --clean and crisp, tight and bright pages, with no writing or markings ... to the text. Read more Show Less

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Overview

Since the 1940s, the American Psychopathological Association has been a driving force in psychiatric genetic research. Having studied the Kallmann and Kety Hoch Award papers, many researchers have attempted to advance psychiatric genetic knowledge from epidemiological findings to biological findings.

Genetic Approaches to Mental Disorders provides the latest information on the relationship between genetics and mental disorders. Divided into four sections, this book presents analysis of the genetic data, linkage mapping and association, debate over genetic Kraepelinian dichotomy, and mapping and association results in psychiatry.

American Psychiatric Publishing

This book contains black-and-white illustrations.

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Editorial Reviews

From The Critics
Reviewer: Howard M. Kravitz, DO, MPH (Rush University Medical Center)
Description: This book comprises the proceedings of the 82nd annual meeting of the American Psychopathological Association. Papers on the relationship between genetics and mental disorders are divided into four sections: analysis of genetic data; linkage mapping and association; debate over genetic kraepelinian dichotomy; and mapping and association results in psychiatry.
Purpose: The purpose is to present the latest information on psychiatric genetics. In accomplishing these objectives, the book is presented at a level more appropriate for clinical researchers than for practicing clinicians, especially the first two sections.
Audience: Although suggested for psychiatrists and geneticists, this recommendation should be qualified as a book for research-oriented clinicians. The general psychiatric clinician may find most of the first two sections presumes a basic knowledge of quantitative and molecular genetics. The authors, experts in their fields, articulate well what is known as well as the limitations of the current state of psychiatric genetics. I would have liked a full chapter by Kendler.
Features: The text is well written and edited, with very readable print on good quality paper. Figures and tables complement the text, and references from 1993 are included (the meeting was in 1992). This is not the usual tedious postproceedings publication. The apparent updating of the text and references and the smooth flow and continuity with little redundancy are evidence of a unique effort to make this a valuable communication.
Assessment: This is an up-to-date book on the state of the knowledge and the controversies in psychiatric genetics. However, because the text is not written at a basic introductory level and requires familiarity with genetic concepts, it may not appeal to the clinically oriented general psychiatrist. Geneticists with an interest in psychiatry will find that the clinical and genetic epidemiology oriented chapters provide a nice substantive overview of the state of the field. Medical libraries should carry a copy, and it should be available in medical bookstores.
Howard M. Kravitz
This book comprises the proceedings of the 82nd annual meeting of the American Psychopathological Association. Papers on the relationship between genetics and mental disorders are divided into four sections: analysis of genetic data; linkage mapping and association; debate over genetic kraepelinian dichotomy; and mapping and association results in psychiatry. The purpose is to present the latest information on psychiatric genetics. In accomplishing these objectives, the book is presented at a level more appropriate for clinical researchers than for practicing clinicians, especially the first two sections. Although suggested for psychiatrists and geneticists, this recommendation should be qualified as a book for research-oriented clinicians. The general psychiatric clinician may find most of the first two sections presumes a basic knowledge of quantitative and molecular genetics. The authors, experts in their fields, articulate well what is known as well as the limitations of the current state of psychiatric genetics. I would have liked a full chapter by Kendler. The text is well written and edited, with very readable print on good quality paper. Figures and tables complement the text, and references from 1993 are included (the meeting was in 1992). This is not the usual tedious postproceedings publication. The apparent updating of the text and references and the smooth flow and continuity with little redundancy are evidence of a unique effort to make this a valuable communication. This is an up-to-date book on the state of the knowledge and the controversies in psychiatric genetics. However, because the text is not written at a basic introductory level and requires familiarity withgenetic concepts, it may not appeal to the clinically oriented general psychiatrist. Geneticists with an interest in psychiatry will find that the clinical and genetic epidemiology oriented chapters provide a nice substantive overview of the state of the field. Medical libraries should carry a copy, and it should be available in medical bookstores.
Booknews
Reviews the latest findings on the links between genetics and mental disorders for professionals in either field. The 22 papers are from the American Psychopathological Association annual meeting, apparently in 1990. They cover the analysis of genetic data, linkage mapping and association, the debate on whether there is a genetic Kraepelinian dichotomy for manic-depressive illness and schizophrenia, and the impact of research on psychiatry. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780880489515
  • Publisher: American Psychiatric Publishing, Incorporated
  • Publication date: 1/1/1994
  • Series: American Psychopathological Association Series
  • Edition description: 1st ed
  • Edition number: 1
  • Pages: 394
  • Product dimensions: 6.00 (w) x 9.00 (h) x 1.10 (d)

Meet the Author

Eliott S. Gershon, M. D., is Chief of the Clinical Neurogenetics Branch at the National Institute of Mental Health in Bethesda, Maryland.

C. Robert Clonninger, M.D., is the Wallace Renard Professor and Head of the Department of Psychiatry at Washington University School of Medicine in St. Louis, Missouri.

American Psychiatric Publishing

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Table of Contents

Analysis of Genetic Data. Values, power, and pitfalls in the linkage analysis of psychiatric disorders. Problems of replicating linkage claims in psychiatry. Mapping genes for psychiatric disorders. Choice of genetic models for linkage analysis of psychiatric traits. Genetic heterogeneity and other complex models: a problem for linkage detection. Sensitivity of linkage analysis to changes in diagnosis: what happens to lod scores when one person changes diagnostic status. Genetic analysis. Linkage Mapping and Association. Linkage mapping using short tandem repeat polymorphisms. An approach to identifying genes that predispose to schizophrenia. The genetic linkage map. Debate: Is There a Genetic Kraepelinian Dichotomy for Manic-Depressive Illness and Schizophrenia? Pro: tests of alternative models of the relationship of schizophrenic and affective psychoses. Con: the demise of the Kraepelinian binary system as a prelude to genetic advance. Discussion of debate: is there a genetic Kraepelinian dichotomy for manic-depressive illness and schizophrenia? Mapping and Association Results in Psychiatry. Detecting discrete genes for susceptibility to manic-depressive illness or schizophrenia. Genetic linkage analysis and clinical approaches to the resolution of heterogeneity in the schizophrenias. Is there a gene for manic-depressive illness on the long arm of the X chromosome? A systematic search for vulnerability genes in bipolar disorder. The Iowa linkage study of panic disorder. Is there a single locus contributing to alcohol vulnerability? D2dopamine receptor genotype and linkage disequilibrium and dopamine function in Finnish, American Indian, and U. S. Caucasian patients. Linkage study of panic disorder: a preliminary report. Identification of clinical phenotypes for genetic research on mental disorders. Index.

American Psychiatric Publishing

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