Genetic Breakthroughs-- Their Implications for You and Your Health (Collection) [NOOK Book]

Overview

3 cutting-edge books reveal the latest genetic breakthroughs – and their implications for you, your health, and your world

These three cutting-edge books reveal how modern genetics has already transformed the world – and will transform it again and again in the coming years. Mobile DNA book thoroughly reviews our current scientific understanding of the significant role that mobile genetic elements play in the evolution and function of genomes and organisms–from plants and ...

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Genetic Breakthroughs-- Their Implications for You and Your Health (Collection)

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Overview

3 cutting-edge books reveal the latest genetic breakthroughs – and their implications for you, your health, and your world

These three cutting-edge books reveal how modern genetics has already transformed the world – and will transform it again and again in the coming years. Mobile DNA book thoroughly reviews our current scientific understanding of the significant role that mobile genetic elements play in the evolution and function of genomes and organisms–from plants and animals to humans. Renowned geneticist Haig Kazazian offers an accessible intellectual history of the field’s research strategies and concerns, explaining how advances have opened up new questions, and how new tools and capabilities have encouraged still more progress. He introduces today’s key strategies for advancing the field, and previews long-term research strategies that may lead to even deeper insights. Next, in Investigating the Human Genome, leading medical genetics scholar Moyra Smith reviews current and recent work in genetics and genomics to assess progress in understanding human variation and the pathogenesis of common and rare diseases linked to genetics. You’ll discover how these advances are shedding new light on issues ranging from human origins to psychiatric disease, Alzheimer’s to epigenetics. Finally, in Genes, Chromosomes, and Disease, Nicholas Wright Gillham offers an exceptionally readable overview of the rise and transformations of medical genetics – and of the eugenic impulses that it has inspired.

From world-renowned leaders and experts, including Haig H. Kazazian, Moyra Smith, and Nicholas Wright Gillham

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Product Details

  • ISBN-13: 9780133039634
  • Publisher: Pearson Education
  • Publication date: 3/12/2012
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 1
  • Pages: 864
  • File size: 6 MB

Meet the Author

Haig H. Kazazian spent 25 years on the Johns Hopkins faculty before joining the University of Pennsylvania School of Medicine as Chair of the Department of Genetics in 1994. In July 2010, he returned to Johns Hopkins as Professor in the Institute of Genetic Medicine. Still heavily involved in molecular genetic research, he has concentrated for 20 years on mammalian and human transposable elements (“jumping genes”). A member of the Institute of Medicine of the National Academy of Sciences and the American Academy of Arts and Sciences, he was awarded the 2008 William Allan Award, the top honor of the American Society of Human Genetics. Moyra Smith is Professor of Pediatrics and Human Genetics at the School of Medicine at University of California, Irvine. A leading scholar in her field, she has served as an editor of McKusick’s classic “Red Book,” Mendelian Inheritance in Man, and has written several monographs in the Oxford Series on Human Genetics. Nicholas Wright Gillham is James B. Duke Professor of Biology emeritus at Duke University. A leading expert on the genetics of cellular organelles, he has a longstanding interest in the history of science. He taught Duke’s innovative course “The Social Implications of Genetics.”

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Table of Contents

Mobile DNA: Finding Treasure in Junk

Preface: Thoughts on Doing Science xii

Chapter 1 Introduction to Mobile DNA 1

Chapter 2 Varieties of Mobile DNA 5

Chapter 3 DNA Transposons 19

Chapter 4 Mobile DNA of Model Organisms 29

Chapter 5 Exceptional Scientists Working on Mobile DNA in Lower Organisms 35

Chapter 6 Role of Bioinformatics in Genome Analysis 43

Chapter 7 The Prologue 49

Chapter 8 “Welcome to the Wonderful World of LINEs” 59

Chapter 9 An Experimental Breakthrough 73

Chapter 10 Reverse Transcriptase to the Rescue 81

Chapter 11 A Quirk of L1 Elements–A Lousy 3’ End Is Important for Genome Evolution 85

Chapter 12 A Tour de Force from Tom Eickbush 89

Chapter 13 “I don’t believe all those colonies represent retrotransposition events.” 93

Chapter 14 L1 Encodes an Endonuclease 101

Chapter 15 The Jocks 105

Chapter 16 The Mayor and the Frenchman 115

Chapter 17 Ostertag’s Coups 121

Chapter 18 The Independent Canadian 133

Chapter 19 The Musician Scientist 141

Chapter 20 Young Ladies in the Back Bay 145

Chapter 21 The Brilliant Young Lady from China 157

Chapter 22 Hiroki’s Big Surprises 163

Chapter 23 A Young Man with a Purpose 173

Chapter 24 Other Mobile DNA in Mammalian Genomes 179

Chapter 25 Effects of Retrotransposons on Mammalian Genomes 187

Chapter 26 Host Factors Involved in L1 Retrotransposition 201

Chapter 27 Why Mobile DNA? 207

Chapter 28 The Future of Mobile DNA Research 209

Chapter 29 Predictions for Mobile DNA 221

References 225

Glossary 249

Index 255

Investigating the Human Genome: Insights into Human Variation and Disease Susceptibility

Preface vii

Chapter 1 Genome Architecture and Sequence Variation in Health and Disease 1

Chapter 2 Genes and Transcripts: Insight into Regulation at Different Levels 23

Chapter 3 Epigenetics: Modifications of DNA, Chromatin, and Gene Expression 37

Chapter 4 Gene Environment Interactions 53

Chapter 5 Pathways, Phenotypes, and Phenocopies 67

Chapter 6 Dynamic Function, Synaptic Activity, and Plasticity 81

Chapter 7 Late Onset Neurodegenerative Diseases 101

Chapter 8 Genes and Genomes in Cancer: Targeted Therapies 131

Chapter 9 Functional Genomics: Personalized Medicine and Therapeutics 153

Epilogue 167

References 171

About the Author 203

Index 205

Genes, Chromosomes, and Disease: From Simple Traits, to Complex Traits, to Personalized Medicine

Preface ix

Chapter 1: Hunting for disease genes 1

Chapter 2: How genetic diseases arise 25

Chapter 3: Ethnicity and genetic disease 55

Chapter 4: Susceptibility genes and risk factors 81

Chapter 5: Genes and cancer 103

Chapter 6: Genes and behavior 129

Chapter 7: Genes and IQ: an unfinished story 151

Chapter 8: Preventing genetic disease 175

Chapter 9: Treating genetic disease 199

Chapter 10: The dawn of personalized medicine 235

Postscript: a cautionary note 249

References and notes 253

Glossary 293

Some useful human genetics Web sites 307

Acknowledgments 309

About the author 311

Index 313

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