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Computer access is the only way to retrieve up-to-date nucleic acid and protein sequence and structure information.
This book, edited by Martin Bishop, describes the available information and where to find it, and is essential reading for any researcher puzzled by the wealth of on-line data.
The reader will be guided through the maze of URLs, sites and searches to reach information on:
• DNA, RNA, protein sequence, and structure databases
• Sequence comparison and alignmen
• Phenotype, mutation and genetic linkage databases
• Simple repetitive DNA sequences
• Gene feature identification
• Prediction of structure and function of proteins from sequence information
The book includes a directory of URLs for easy reference and it will be invaluable to those starting a career in life sciences research and also for established researchers wishing to make full use of available resources.
Audience: Graduates and researchers in genetics, biochemistry, molecular biology, cell biology, immunology, microbiology - any discipline using molecular biology in their research. There is also the possibility of promotion to specific courses, most of which are fairly new. In the US there are 84 courses on 'Computers in Medicine' and 30 courses on 'Computer Applications in Health'. There are also 2 graduate courses in the UK on bioinformatics.
M. Bishop, Introduction.
G. Williams, Nucleic Acid and Protein Sequence Databases.
R. Cotton, Phenotype, Mutation, and Genetic Linkage Databases and Their Links to Sequence Databases.
R. Guigo, DNA Composition, Codon Usage, and Exon Prediction.
W. Taylor, Properties of Amino Acids in Sequences.
M. Gribskov, Sequence Comparison.
J. Epplen, Simple Repetitive Sequences in DNA Databanks.
P. Bucher, Gene Feature Identification.
D. Higgins, Multiple Sequence Alignment.
K. Triman, RNAs.
C. Ponting and D.J. Blake, Predicting the Evolution, Structure, and Function of Proteins from Sequence Information.
D. Jones, Structure Databases and Structure Alignments.
M. Gribskov, Bourne, Smith, Integrated Data Resource for Protein Kinases.
R. Baldock, Gene Expression Databases.
P.D. Karp, Pathways and Development.