Genetic Dissection of Complex Traitsby Elsevier Science
This volume presents a long-awaited collection of state-of-the-art methods and strategies for the genetic dissection of complex human diseases and disease-related risk factors. Written by the world's leading experts in genetic epidemiology, this inspirational volume provides insights into emerging new methods and ideas on how best to tackle the impending challenges… See more details below
This volume presents a long-awaited collection of state-of-the-art methods and strategies for the genetic dissection of complex human diseases and disease-related risk factors. Written by the world's leading experts in genetic epidemiology, this inspirational volume provides insights into emerging new methods and ideas on how best to tackle the impending challenges of the new millenium. These futuristic methods will help fulfill the promise of the Human Genome Project by optimizing our ability to locate these genes. In time, genetic dissection of the major human disease traits will facilitate development of custom-tailored pharmacogenetic treatments. An authentic compilation of these evolving methods has been sorely lacking, and this volume fills that void with multiple approaches to very controversial issues.
Table of Contents
NEWTON MORTON'S CONTRIBUTIONS
Newton Morton: The Wisconsin Years.
Newton Morton's Influence on Genetics: The Morton Number.
OVERVIEW AND PRELIMINARIES
Genetic Dissection of Complex Traits: An Overview.
Familial Resemblance and Heritability.
Linkage and Association: Basic Concepts.
PHENOTYPES AND GENOTYPES
Definition of the Phenotype.
Genotyping for Human Whole-Genome Scans: Past, Present, and Future.
MODEL-BASED METHODS FOR LINKAGE ANALYSIS
The Lod Score Method.
Extension of the Lod Score: The Mod Score.
Major Strengths and Weaknesses of the Lod Score Method.
MODEL-FREE METHODS FOR LINKAGE AND ASSOCIATION ANALYSIS
Overview of Model-free Methods for Linkage Analysis.
Variance Component Methods for Detecting Complex Trait Loci.
Linkage and Association with Structural Relationships.
The Future of Genetic Case-Control Studies.
Cost of Linkage versus Association Methods.
Genotype-Environment Interaction in Transmission Disequilibrium Tests.
Major Strengths and Weaknesses of Model-free Methods.
MORE RECENT METHODS
Meta-analysis for Model-free Methods.
Classification Methods for Confronting Heterogeneity.
Applications of Neural Networks for Gene Finding.
Genome Partitioning and Whole-Genome Analysis.
Deciphering the Genetic Architecture of a Multivariate Phenotype.
On the Resolution and Feasibility of Genome Scanning Approaches.
One-Stage versus Two-Stage Strategies for Genome Scans.
MULTIPLE COMPARISONS AND SIGNIFICANCE LEVELS
Significance Levels in Genome Scans.
False Positives and False Negatives in Genome Scans.
Sequential Methods of Analysis for Genome Scans.
CHALLENGES FOR THE NEW MILLENNIUM
From Genetics to Mechanism of Disease Liability.
Complex Inheritance: The 21st Century.
Appendix: Research Contributions of Newton E. Morton.
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