Genetic Effects on Environmental Vulnerability to Disease / Edition 1

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More About This Textbook

Overview

While much research has attempted to show direct linear relations between genes and disorder, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. An alternative is to use a gene-environment interaction approach that focuses on the circumstances in which there is an environmental determinant of disease but where genes influence susceptibility to that environmental factor.
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Product Details

  • ISBN-13: 9780470777800
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 12/30/2008
  • Series: Novartis Foundation Symposia Series
  • Edition number: 1
  • Pages: 232
  • Product dimensions: 6.20 (w) x 9.00 (h) x 0.60 (d)

Table of Contents

1 Introduction: whither gene-environment interactions? Michael Rutter 1

2 Gene-environment interaction: overcoming methodological challenges Rudolf Uher 13

Discussion 26

3 Gene-environment interaction and behavioral disorders: a developmental perspective based on endophenotypes Marco Battaglia Cecilia Marino Michel Maziade Massimo Molteni Francesca D'Amato 31

Discussion 41

4 Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response Theory Naomi R. Wray William L. Coventry Michael R. James Grant W. Montgomery Lindon J. Eaves Nicholas G. Martin 48

Discussion 59

Appendix 64

General discussion I 68

5 Role of gene-stress interactions in gene finding studies Harold Snieder Xiaoling Wang Vasiliki Lagou Brenda W. J. H. Penninx Harriette Riese Catharina A. Hartman 71

Discussion 83

6 Practice and public policy in the era of gene-environment interactions Kenneth A. Dodge 87

Discussion 97

7 Gene-environment interaction and the metabolic syndrome Kristi B. Adamo Frederique Tesson 103

Discussion 119

General discussion II 122

8 Longitudinal studies of gene-environment interaction in common diseases-good value for money? Stephen P. Robertson Richie Poulton 128

Discussion 138

9 Gene-environment interactions in breast cancer Kee-Seng Chia 143

Discussion 150

10 Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections Malak Kotb Nourtan Fathey Ramy Aziz Sarah Rowe Robert W. Williams Lu Lu 156

Discussion 165

11 Gene-environment interactions inenvironmental lung diseases Steven R. Kleeberger Hye-Youn Cho 168

Discussion 178

General discussion III 181

12 Gene-environment interaction in complex diseases: asthma as an illustrative case Fernando D. Martinez 184

Discussion 192

13 Conclusions: taking stock and looking ahead Michael Rutter 198

Glossary 206

Index of contributors 215

Subject index 217

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