Genetic Effects on Environmental Vulnerability to Disease / Edition 1

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More About This Textbook


While much research has attempted to show direct linear relations between genes and disorder, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. An alternative is to use a gene-environment interaction approach that focuses on the circumstances in which there is an environmental determinant of disease but where genes influence susceptibility to that environmental factor.
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Product Details

  • ISBN-13: 9780470777800
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 12/30/2008
  • Series: Novartis Foundation Symposia Series
  • Edition number: 1
  • Pages: 232
  • Product dimensions: 6.20 (w) x 9.00 (h) x 0.60 (d)

Table of Contents

1 Introduction: whither gene-environment interactions? Michael Rutter 1

2 Gene-environment interaction: overcoming methodological challenges Rudolf Uher 13

Discussion 26

3 Gene-environment interaction and behavioral disorders: a developmental perspective based on endophenotypes Marco Battaglia Cecilia Marino Michel Maziade Massimo Molteni Francesca D'Amato 31

Discussion 41

4 Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response Theory Naomi R. Wray William L. Coventry Michael R. James Grant W. Montgomery Lindon J. Eaves Nicholas G. Martin 48

Discussion 59

Appendix 64

General discussion I 68

5 Role of gene-stress interactions in gene finding studies Harold Snieder Xiaoling Wang Vasiliki Lagou Brenda W. J. H. Penninx Harriette Riese Catharina A. Hartman 71

Discussion 83

6 Practice and public policy in the era of gene-environment interactions Kenneth A. Dodge 87

Discussion 97

7 Gene-environment interaction and the metabolic syndrome Kristi B. Adamo Frederique Tesson 103

Discussion 119

General discussion II 122

8 Longitudinal studies of gene-environment interaction in common diseases-good value for money? Stephen P. Robertson Richie Poulton 128

Discussion 138

9 Gene-environment interactions in breast cancer Kee-Seng Chia 143

Discussion 150

10 Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections Malak Kotb Nourtan Fathey Ramy Aziz Sarah Rowe Robert W. Williams Lu Lu 156

Discussion 165

11 Gene-environment interactions inenvironmental lung diseases Steven R. Kleeberger Hye-Youn Cho 168

Discussion 178

General discussion III 181

12 Gene-environment interaction in complex diseases: asthma as an illustrative case Fernando D. Martinez 184

Discussion 192

13 Conclusions: taking stock and looking ahead Michael Rutter 198

Glossary 206

Index of contributors 215

Subject index 217

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