Genetic Factors in Drug Therapy: Clinical and Molecular Pharmacogenetics

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Genetic Factors in Drug Therapy is the first comprehensive, in-depth survey of the current research on the genetic basis for the wide variety in people's responses to drugs. Dr. Evans shows how understanding inherited differences in the rates at which people metabolize drugs and in their response to drugs in general leads to a clearer conception of—and can help to predict—adverse reactions to drugs, responses to the drug treatment of disease, and the occurrence of spontaneous disorders. New discoveries have ...

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Overview

Genetic Factors in Drug Therapy is the first comprehensive, in-depth survey of the current research on the genetic basis for the wide variety in people's responses to drugs. Dr. Evans shows how understanding inherited differences in the rates at which people metabolize drugs and in their response to drugs in general leads to a clearer conception of—and can help to predict—adverse reactions to drugs, responses to the drug treatment of disease, and the occurrence of spontaneous disorders. New discoveries have allowed scientists to develop methods for direct genotyping of a person's DNA, permitting them to predict with greater accuracy a given individual's likely response to a course of drug treatment.

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Product Details

  • ISBN-13: 9780521412964
  • Publisher: Cambridge University Press
  • Publication date: 12/16/1993
  • Pages: 681
  • Product dimensions: 7.01 (w) x 10.00 (h) x 2.40 (d)

Table of Contents

Preface
1 The arrangement of the information in this volume 1
2 General introduction 2
3 Classification of pharmacogenetic phenomena 6
4 Cytochromes P450 - general features 9
5 Arylhydrocarbon hydroxylase (cytochrome P450 lA1 and lA2) 19
6 The mephenytoin hydroxylation polymorphism (cytochrome P450 2C18) 35
7 The debrisoquine/sparteine polymorphism (cytochrome P450 2D6) 54
8 The cytochrome P450 3A subfamily 102
9 Tolbutamide 113
10 Phenytoin 119
11 Some other drugs of special interest 132
12 Cytochrome P450 reductase 134
13 General conclusions 135
14 Cholinesterase 137
15 Alcohol and alcoholism 177
16 N-Acetyltransferase 211
17 The glucosidation of amobarbital 303
18 Glucuronosyltransferases 306
19 Glutathione-S-transferase 317
20 Methylation reactions 330
21 Paraoxonase 346
22 Sulphotransferases 364
23 Sulphoxidation deficiency 371
24 Halothane hepatitis and other topics 382
25 Glucose-6-phosphate dehydrogenase deficiency 391
26 The hepatic porphyrias 423
27 Malignant hyperthermia 459
28 Chlorpropamide-alcohol flushing 489
29 Glucocorticosteroids and intraocular pressure 499
30 Unstable haemoglobins 507
31 Human lymphocyte antigens and adverse reactions to drugs 512
32 The polymorphism for tasting phenylthiocarbamide (PTC syn phenylthiourea) 518
33 Hereditary anticoagulant resistance 547
34 NADH-cytochrome b5 reductase 555
35 Catalase 568
36 Antibiotic-induced deafness, chloramphenicol toxicity and other topics 574
37 Polygenic effects in pharmacogenetics 585
38 Common themes 593
39 Conclusions 615
Appendix I Computing the degree of dominance 619
Appendix II Exponential decay 621
Appendix III The disentanglement of overlapping frequency distribution curves 622
Appendix IV Chromosomal locations of genes 625
Appendix V General bibliography 627
Index 629
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