Genetic Predisposition to Cancer

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Genetic Predisposition to Cancer will be an invaluable guide for trainee and consultant/attending oncologists in clinical practice and research, and a useful reference for clinical geneticists and other allied health professionals involved in the care of patients with, and who may be at genetic risk for, cancer.

Mechanism of action of predisposing genes/retinoblastoma genetics/familial risk of breast cancer/familial melanoma.

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Overview

Genetic Predisposition to Cancer will be an invaluable guide for trainee and consultant/attending oncologists in clinical practice and research, and a useful reference for clinical geneticists and other allied health professionals involved in the care of patients with, and who may be at genetic risk for, cancer.

Mechanism of action of predisposing genes/retinoblastoma genetics/familial risk of breast cancer/familial melanoma.

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Editorial Reviews

From the Publisher
...valuable to a wide audience
British Medical Journal
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Product Details

  • ISBN-13: 9780412565809
  • Publisher: Taylor & Francis
  • Publication date: 3/1/1996
  • Series: A Hodder Arnold Publication Series
  • Edition number: 1
  • Pages: 432
  • Product dimensions: 7.20 (w) x 9.70 (h) x 1.20 (d)

Meet the Author

Rosalind A. Eeles is Clinical Senior Lecturer and Honorary Consultant in Cancer Genetics and Clinical Oncology; Team Leader, Translation Cancer Genetics Team, Institute of Cancer Research; and Head, Cancer Genetics Unit, Royal Marsden NHS Trust, Sutton, UK
Douglas F. Easton is Director, Cancer Research UK Genetic Epidemiology Unit, Strangeways Research Laboratory, Cambridge, UK
Bruce A. J. Ponder is Cancer Research UK Professor of Oncology; Director, Cancer Research UK Human Genetics Research Group; and Co-Director, Hutchison-MRC Research Centre and Strangeways Laboratory for Genetic Epidemiology, University of Cambridge, UK
Charis Eng is Dorothy E. Klotz Chair of Cancer Research; William C. and Joan E. Davis Professor of Cancer Research; Professor & Director, Division of Human Genetics, Department of Internal Medicine; and Director, Clinical Cancer Genetics Program, The Ohio State University, Columbus, Ohio, USA
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Table of Contents

Foreword
Foreword
1 Genetic predisposition to cancer : an introduction 3
2 Biological basis of cancer predisposition 11
3 From families to chromosomes : genetic linkage and association studies for finding cancer-predisposition genes 21
4 From chromosomes to genes : how to isolate cancer-predisposition genes 41
5 Screening for mutations in cancer-predisposition genes 48
6 Retinoblastoma : the paradigm for a genetically inherited cancer syndrome 63
7 Neurofibromatosis types 1 and 2 73
8a Multiple endocrine neoplasia type 1 97
8b Multiple endocrine neoplasia type 2 105
9 Wilms tumour and other childhood renal tumours 119
10 Genetic susceptibility to renal cell carcinoma 132
11 The Li-Fraumeni syndrome and the role of TP53 mutations in predisposition to cancer 141
12 Cowden syndrome 155
13 Clinical, cellular and mutational variations in ataxia telangiectasia 169
14 Fanconi anaemia 180
15 The Gorlin (nevoid basal cell carcinoma) syndrome 193
16 Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy : sun sensitivity, DNA repair defects and skin cancer 214
17 Genetics and the common cancers 235
18 Familial breast cancer 248
19 The BRCA1 and BRCA2 genes 256
20 Screening for breast cancer in high-risk populations 277
21 Risk-reducing mastectomy 286
22 The role of chemoprevention in breast cancer 296
23 Familial ovarian cancer : genetics and management 303
24 Familial colon cancer syndromes and their genetics 315
25 Screening and management of familial colon cancer 331
26 Familial prostate cancer and its management 339
27 Familial melanoma and its management 352
28 Familial predisposition to lung cancer 360
29 Genetic susceptibility to carcinoma of the head and neck, stomach, and pancreas 368
30 The cancer family clinic 391
31 Psychological issues in cancer genetics 404
32 The ethics of testing for cancer-predisposition genes 414
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