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Doody's Review ServiceReviewer: Roger W. Melvold, PhD (Northwestern University Feinberg School of Medicine)
Description: This book is the published proceedings of a 1994 symposium on interactions between DNA and metals, and it spans areas from molecular interactions to human genetic diseases.
Purpose: The 29 papers are divided into four general areas. The first section contains reports on the mutagenic and/or carcinogenic effects of metals. The second section includes papers on the role(s) of metal-containing compounds, such as zinc fingers and metalloporphyrins, in the binding and/or cleavage of DNA. The third section contains several papers on human genetic diseases, Merkes disease and Wilson disease, which result from defective transport and metabolic use of copper. Finally, the last section deals with the role(s) of metals in gene regulation, primarily metallothione systems, in yeast and in mammalian cells.
Audience: The book is directed at investigators in the area as well as at library collections. It is unsuitable for classroom use.
Features: The illustrations are all black-and-white and are appropriate to the material.
Assessment: This particular collection of papers brings together chemical/biochemical and genetic considerations on the role of metals in DNA structure and function. Although many question the value of published symposium proceedings, this volume does provide an interesting aggregation of topics unlikely to occur often under other circumstances.