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Genetic Response to Metals / Edition 1

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New York 1995 Hardcover New 488 pgs. BRAND NEW with very slight shelf wear. **We provide professional service and individual attention to your order, daily shipments, and sturdy ... packaging. e are a family business providing individual attention to each order. Read more Show Less

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Overview

"Based on the First International Symposium on Metals and Genetics held recently at the Hospital for Sick Children in Toronto, Ontario, Canada. The only book of its kind to focus on the effects of metals on DNA. Provides up-to-date information on new developments in the field and their wide-ranging implications. Discusses the molecular mechanisms of metal-induced mutagenicity and carcinogenicity."

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Roger W. Melvold, PhD (Northwestern University Feinberg School of Medicine)
Description: This book is the published proceedings of a 1994 symposium on interactions between DNA and metals, and it spans areas from molecular interactions to human genetic diseases.
Purpose: The 29 papers are divided into four general areas. The first section contains reports on the mutagenic and/or carcinogenic effects of metals. The second section includes papers on the role(s) of metal-containing compounds, such as zinc fingers and metalloporphyrins, in the binding and/or cleavage of DNA. The third section contains several papers on human genetic diseases, Merkes disease and Wilson disease, which result from defective transport and metabolic use of copper. Finally, the last section deals with the role(s) of metals in gene regulation, primarily metallothione systems, in yeast and in mammalian cells.
Audience: The book is directed at investigators in the area as well as at library collections. It is unsuitable for classroom use.
Features: The illustrations are all black-and-white and are appropriate to the material.
Assessment: This particular collection of papers brings together chemical/biochemical and genetic considerations on the role of metals in DNA structure and function. Although many question the value of published symposium proceedings, this volume does provide an interesting aggregation of topics unlikely to occur often under other circumstances.
Roger W. Melvold
This book is the published proceedings of a 1994 symposium on interactions between DNA and metals, and it spans areas from molecular interactions to human genetic diseases. The 29 papers are divided into four general areas. The first section contains reports on the mutagenic and/or carcinogenic effects of metals. The second section includes papers on the role(s) of metal-containing compounds, such as zinc fingers and metalloporphyrins, in the binding and/or cleavage of DNA. The third section contains several papers on human genetic diseases, Merkes disease and Wilson disease, which result from defective transport and metabolic use of copper. Finally, the last section deals with the role(s) of metals in gene regulation, primarily metallothione systems, in yeast and in mammalian cells. The book is directed at investigators in the area as well as at library collections. It is unsuitable for classroom use. The illustrations are all black-and-white and are appropriate to the material. This particular collection of papers brings together chemical/biochemical and genetic considerations on the role of metals in DNA structure and function. Although many question the value of published symposium proceedings, this volume does provide an interesting aggregation of topics unlikely to occur often under other circumstances.
Booknews
Based on the First International Symposium on Metals and Genetics, held in Toronto, Canada, May 1994, this volume provides a forum for investigators from diverse fields ranging from genetics to biochemistry and chemistry to reflect on the broad impact of the direct and indirect interactions of metals and DNA. The 29 chapters are arranged within four sections: molecular mechanism of metal- induced mutagenicity and carcinogenicity; metal-DNA, DNA cleavage, and zinc-finger proteins; metal-related genetic diseases--Menkes and Wilson diseases; and metals and gene regulation. Annotation c. Book News, Inc., Portland, OR booknews.com

3 Stars from Doody
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Product Details

  • ISBN-13: 9780824796150
  • Publisher: CRC Press
  • Publication date: 4/28/1995
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 512
  • Product dimensions: 6.25 (w) x 9.25 (h) x 1.00 (d)

Table of Contents

Part 1 Molecular mechanism of metal induced mutagenicity and carcinogenicity: regulation of nuclear calcium and zinc interference by toxic metal ions; effects of antioxidants, zinc, and chelators on free radical status of children living in the chernobyl area; the role of ascorbate in metabolism and geno-toxicity of chromium (VI); inactivation of critical cancer-related genes by nickel-induced DNA hypermethylation and increased chromatin condensation - a new model for epigenetic carcinogenesis; oxidative mechanisms of nickel(II) and cobalt(II) genotoxicity; the antimutagenic effects of metallothionein may involve free radical scavenging; protection from metal-induced DNA damage by metallothionein in an in vitro system; DNA strand breakage and lipid peroxidation as possible mechanisms of selenium toxicity; role of metal in oxidative DNA damage by nonmutagenic carcinogen. Part 2 Metal-DNA, DNA cleavage, and zinc-finger proteins: sequence-selective cleavage of DNA by cationic metalloporphyrins; lanthanide(III) complexes as synthetic nucleases - hydroxyalkyl group participation in catalysis; initiation of DNA strand cleavage by iron bleomycin - key role of DNA in determining the pathway of reaction; nickel complexes in modification of nucleic acids; new methods for determining the structure of DNA and DNA-protein complexes based on the chemistry of iron(II) EDTA; DNA recognition by steroid hormone receptor zinc fingers - effects of metal replacement and protein-protein dimerization interface; HIV-1 tat protein forms a zinc-finger-like structure. Part 3 Metal-related genetic diseases - Menkes and Wilson diseases: Menkes disease - from patients to gene; variability in clinical expression of an X-linked copper disturbance, Menkes disease; development of copper-histidine treatment for Menkes disease; copper-histidine therapy in Menkes disease - clinical, biochemical, and molecular aspects; biochemical and clinical benefits of copper-histidine therapy in Menkes disease; the Wilson disease gene - a copper-binding ATPase homologous to the Menkes disease gene; zinc therapy - an advance in the treatment of Wilson's disease. Part 4 Metals and gene regulation: transcriptional regulation and function of yeast metallothionein genes; transcriptional regulation of the metallothionein gene - metal-responsive element and zinc regulatory factor.

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