Genetic Response to Metals / Edition 1

Genetic Response to Metals / Edition 1

by Sarkar
     
 

ISBN-10: 0824796152

ISBN-13: 9780824796150

Pub. Date: 04/28/1995

Publisher: Taylor & Francis

"Based on the First International Symposium on Metals and Genetics held recently at the Hospital for Sick Children in Toronto, Ontario, Canada. The only book of its kind to focus on the effects of metals on DNA. Provides up-to-date information on new developments in the field and their wide-ranging implications. Discusses the molecular mechanisms of metal-induced

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Overview

"Based on the First International Symposium on Metals and Genetics held recently at the Hospital for Sick Children in Toronto, Ontario, Canada. The only book of its kind to focus on the effects of metals on DNA. Provides up-to-date information on new developments in the field and their wide-ranging implications. Discusses the molecular mechanisms of metal-induced mutagenicity and carcinogenicity."

Product Details

ISBN-13:
9780824796150
Publisher:
Taylor & Francis
Publication date:
04/28/1995
Edition description:
New Edition
Pages:
512
Product dimensions:
6.25(w) x 9.25(h) x 1.00(d)

Table of Contents

Part 1 Molecular mechanism of metal induced mutagenicity and carcinogenicity: regulation of nuclear calcium and zinc interference by toxic metal ions; effects of antioxidants, zinc, and chelators on free radical status of children living in the chernobyl area; the role of ascorbate in metabolism and geno-toxicity of chromium (VI); inactivation of critical cancer-related genes by nickel-induced DNA hypermethylation and increased chromatin condensation - a new model for epigenetic carcinogenesis; oxidative mechanisms of nickel(II) and cobalt(II) genotoxicity; the antimutagenic effects of metallothionein may involve free radical scavenging; protection from metal-induced DNA damage by metallothionein in an in vitro system; DNA strand breakage and lipid peroxidation as possible mechanisms of selenium toxicity; role of metal in oxidative DNA damage by nonmutagenic carcinogen. Part 2 Metal-DNA, DNA cleavage, and zinc-finger proteins: sequence-selective cleavage of DNA by cationic metalloporphyrins; lanthanide(III) complexes as synthetic nucleases - hydroxyalkyl group participation in catalysis; initiation of DNA strand cleavage by iron bleomycin - key role of DNA in determining the pathway of reaction; nickel complexes in modification of nucleic acids; new methods for determining the structure of DNA and DNA-protein complexes based on the chemistry of iron(II) EDTA; DNA recognition by steroid hormone receptor zinc fingers - effects of metal replacement and protein-protein dimerization interface; HIV-1 tat protein forms a zinc-finger-like structure. Part 3 Metal-related genetic diseases - Menkes and Wilson diseases: Menkes disease - from patients to gene; variability in clinical expression of an X-linked copper disturbance, Menkes disease; development of copper-histidine treatment for Menkes disease; copper-histidine therapy in Menkes disease - clinical, biochemical, and molecular aspects; biochemical and clinical benefits of copper-histidine therapy in Menkes disease; the Wilson disease gene - a copper-binding ATPase homologous to the Menkes disease gene; zinc therapy - an advance in the treatment of Wilson's disease. Part 4 Metals and gene regulation: transcriptional regulation and function of yeast metallothionein genes; transcriptional regulation of the metallothionein gene - metal-responsive element and zinc regulatory factor.

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