Genetic Testing for Alzheimer Disease: Ethical and Clinical Issues

Overview

The genetics of Alzheimer disease has been a point of intense concern and immense informational confusion for families in which a loved one is diagnosed with dementia. In recent years, however, scientists have begun to uncover the genetic bases for some forms of Alzheimer disease. Once a chromosomal defect is identified, it becomes possible to devise a test for its presence. The far-reaching implications of such tests are the focus of the present volume.

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SHRINKWRAPPED SHIPS FROM USA : DESCRIPTION: 304 Pages: The Johns Hopkins University Press; 1 edition (August 25, 1998) : The genetics of Alzheimer disease has been a point of ... intense concern and immense informational confusion for families in which a loved one is diagnosed with dementia. In recent years, however, scientists have begun to uncover the genetic bases for some forms of Alzheimer disease. Once a chromosomal defect is identified, it becomes possible to devise a test for its presence. The far-reaching implications of such tests are the focus of the present volume. In Genetic Testing for Alzheimer Disease, Stephen G. Post and Peter J. Whitehouse bring together experts from the fields of ethics, genetics, policy, neurology, philosophy, and anthropology to examine the ethical and social aspects of genetic testing for Alzheimer disease. The authors begin by focusing on current genetic findings and their clinical applicability. They then address ethical issues in genetic testing and genetic counseling for Alzheimer disease. They examine social issues such as confidentiality, discrimination, and fairness in health care. Finally, they discuss ways to educate professionals and laypeople regarding these issues. Read more Show Less

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Overview

The genetics of Alzheimer disease has been a point of intense concern and immense informational confusion for families in which a loved one is diagnosed with dementia. In recent years, however, scientists have begun to uncover the genetic bases for some forms of Alzheimer disease. Once a chromosomal defect is identified, it becomes possible to devise a test for its presence. The far-reaching implications of such tests are the focus of the present volume.

In Genetic Testing for Alzheimer Disease, Stephen G. Post and Peter J. Whitehouse bring together experts from the fields of ethics, genetics, policy, neurology, philosophy, and anthropology to examine the ethical and social aspects of genetic testing for Alzheimer disease. The authors begin by focusing on current genetic findings and their clinical applicability. They then address ethical issues in genetic testing and genetic counseling for Alzheimer disease. They examine social issues such as confidentiality, discrimination, and fairness in health care. Finally, they discuss ways to educate professionals and laypeople regarding these issues.

Contributors: Robert H. Binstock, Ph.D.•Thomas D. Bird, M.D. • Robert Mullan Cook-Deegan, M.D.• Leonard Fleck, Ph.D. • Atwood D. Gaines, Ph.D, M.P.H. • Eric T. Juengst, Ph.D. • Harry Karlinsky, M.D. • Steven Miles, M.D. • Thomas H. Murray, Ph.D. • Stephen G. Post, Ph.D. • Kimberly A. Quaid, Ph.D. • Allen D. Roses, M.D. • Greg A. Sachs, M.D. • Peter H. St. George-Hyslop, M.D. • Bonnie Steinbock, Ph.D. • Arthur B. Zinn, M.D., Ph.D.

The book contains black-and-white illustrations.

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Editorial Reviews

New England Journal of Medicine
This book's thoughtful approach to the fascinating yet complicated subject of genetic testing for Alzheimer's disease can serve as a model for the myriad other similar ethical and medical conflicts found today in modern medicine.
Booknews
In recent years, scientists have begun to uncover the genetic basis for some forms of Alzheimer disease. Sixteen papers examine the clinical, ethical, social, and educational implications of this discovery in connection with therapeutic interventions, prenatal genetic testing, managed care issues, genetics and long term care insurance, the primary care physician, and justice and rights. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780801858406
  • Publisher: Johns Hopkins University Press
  • Publication date: 8/25/1998
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 284
  • Product dimensions: 6.31 (w) x 9.27 (h) x 1.03 (d)

Meet the Author

Stephen G. Post, Ph.D., is an associate professor at the Center for Biomedical Ethics at the Case Western Reserve School of Medicine. He is the author of The Moral Challenge of Alzheimer Disease. Peter J. Whitehouse, M.D., Ph.D., is a professor of neurology at the CWRU Alzheimer Center at the Fairhill Center on Aging.

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Table of Contents

Acknowledgments
List of Contributors
1 Introduction: Genetics and the Moral Future of Dementia Care 1
Pt. 1 The Genetics of Alzheimer Disease
2 The Chromosome 1 Type of Familial Alzheimer Disease 17
3 Molecular Genetics of Early-Onset Alzheimer Disease Linked to Chromosome 14 and Chromosome 21 25
4 A New Paradigm for Clinical Evaluations of Dementia: Alzheimer Disease and Apolipoprotein E Genotypes 37
5 Therapeutic Interventions in Alzheimer Disease: Implications of Genetic Advances 65
6 Some Questions Arising in the Commercial Development of Genetic Tests for Alzheimer Disease 84
Pt. 2 Ethical Aspects
7 Genetic Testing and Counseling for Early-Onset Autosomal-Dominant Alzheimer Disease 103
8 Implications of Genetic Susceptibility Testing with Apolipoprotein E 118
9 Prenatal Genetic Testing for Alzheimer Disease 140
Pt. 3 Social Issues
10 Genetics and Long-Term-Care Insurance: Ethical and Policy Issues 155
11 The Ethical Implications of Alzheimer Disease Risk Testing for Other Clinical Uses of APOE Genotyping 177
12 Justice, Rights, and Alzheimer Disease Genetics 190
13 Managed Care Issues in Genetic Testing for Alzheimer Disease 209
Pt. 4 Educational Issues
14 Education for a Too-Hopeful Public 225
15 Alzheimer Genetics and the Primary Care Physician 239
16 Culture and Values at the Intersection of Science and Suffering: Encountering Ethics, Genetics, and Alzheimer Disease 256
Index 275
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