Genetic Variation and Human Disease: Principles and Evolutionary Approaches / Edition 1by Kenneth M. Weiss, Weiss
Pub. Date: 03/28/2004
Publisher: Cambridge University Press
This book provides an overview of the concepts and methods needed to understand the genetic basis of biological traits, including disease, in humans. See more details below
This book provides an overview of the concepts and methods needed to understand the genetic basis of biological traits, including disease, in humans.
- Cambridge University Press
- Publication date:
- Cambridge Studies in Biological and Evolutionary Anthropology Series, #11
- Edition description:
- Product dimensions:
- 5.98(w) x 8.98(h) x 0.83(d)
Table of Contents
Preface; Part I. Genes and Their Expression: 1. What is a gene?; 2. The logic of the genome; 3. Concepts of frequency and association in populations; 4. Genes and phenotypes in populations; Part II. Introduction to Genetic Epidemiology: Inference from Observational Data: 5. Segregation analysis: discrete traits in families; 6. Segregation analysis: quantitative traits in families; 7. Linkage analysis: finding and mapping genes for qualitative traits; 8. Linkage analysis: finding and mapping genes for quantitative traits; Part III. Evolution: The Time Dimension in Populations: 9. Genes over time and space; 10. Reconstructing history: the footprints of evolution; 11. Evolution generates heterogeneity; Part IV. Modification of the Inherited Genotype: The Time Dimension in Individuals: 12. Phenotype amplification by the environment; 13. Infectious disease: the response to biological challenge; 14. Variation within the inherited genotype; 15. Cancer and ageing: a microcosm of evolution during life; Afterwords: towards a unified general model; Conclusion; Notes; References; Index.
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