Genetics and Cancer: A Second Look

Overview

Cancer Surveys is produced as a service to all concerned with cancer, whether in diagnosis, treatment or research. It is published for the Imperial Cancer Research Fund by Cold Spring Harbor Laboratory Press and is advised by a strong international Editorial Board. Its main purpose is to break down the isolation between different disciplines by bridging the gap between the laboratory, the clinic and the epidemiologist so that each is aware of the state of the art and of the problems in related fields. Each issue ...
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1995 Hard cover Illustrated. Perfectly brand new(still in publisher's shrinkwrap)! ! -ships immediately Glued binding. 410 p. Contains: Illustrations. Cancer Surveys, 25. ... Audience: General/trade. Read more Show Less

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Overview

Cancer Surveys is produced as a service to all concerned with cancer, whether in diagnosis, treatment or research. It is published for the Imperial Cancer Research Fund by Cold Spring Harbor Laboratory Press and is advised by a strong international Editorial Board. Its main purpose is to break down the isolation between different disciplines by bridging the gap between the laboratory, the clinic and the epidemiologist so that each is aware of the state of the art and of the problems in related fields. Each issue in the series provides a comprehensive survey of the present state and future developments in a well-defined area in oncology in which there is current scientific or clinical interest. Each issue has one or more Guest Editors who have a special knowledge of the specific field. They provide a general assessment. The invited papers are from leaders in the field and are original contributions reviewing the author's own work, including as much new information as possible and setting the work in context. Authors are encouraged to use a selective approach, discussing those areas which they feel to be important, misunderstood or misinterpreted. They are also encouraged to identify areas of confusion and to speculate on possible ways forward. In particular, the possible interrelationship between laboratory and clinical findings is stressed. The enormous output of papers directly related to cancer and the many others dealing with the wide range of biological topics of interest to cancer workers make it almost impossible to keep track of new developments. Cancer Surveys provides a co-ordinated assessment of the relevance of new findings in the particular field considered in each issue.
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Editorial Reviews

Booknews
An update of cancer genetics now that many of the genes responsible for the major dominant inherited cancer syndromes have been cloned and identified through mutation detection, the research has been driven into cell biology and protein biochemistry and structure, and the resulting health care has become sophisticated enough to generate ethical debates. The topics include the genetic epidemiology of cancer, genomic imprinting, programmed cell death, and the molecular genetics of several types of cancer. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780879694692
  • Publisher: Cold Spring Harbor Laboratory Press
  • Publication date: 1/28/1995
  • Series: Cancer Surveys Series
  • Edition number: 1
  • Pages: 410

Table of Contents

Introduction 1
Prospects for Cancer Genetics 3
The Genetic Epidemiology of Cancer 13
Metabolic Polymorphisms and Cancer Susceptibility 27
Genetics of Embryonal Tumours of Childhood: Retinoblastoma, Wilms' Tumour and Neuroblastoma 67
Germline Mutations in the TP53 Gene 101
Nucleotide Excision Repair: Variations Associated with Cancer Development and Speciation 125
Role of Transgenie Mice in Identification and Characterization of Tumour Suppressor Genes 143
Genomic Imprinting and Cancer 161
The Genetics of Programmed (Apoptotic) Cell Death 173
Mutations of the RET Proto-oncogene in Multiple Endocrine Neoplasia Type 2 195
The Neurofibromatosis 2 (NF2) Tumour Suppressor Gene: Implications Beyond the Hereditary Tumour Syndrome? 207
Von Hippel-Lindau Disease and Sporadic Renal Cell Carcinoma 219
Genetics and Malignant Progression of Human Brain Tumours 233
Recent Advances in the Molecular Genetics of Malignant Melanoma 277
Molecular Genetics of Lung Cancer 293
Molecular Genetics of Sporadic and Familial Breast Cancer 315
Emergent Issues in the Genetics of Intestinal Neoplasia 335
Molecular Genetics of Prostate Cancer 357
Ethical, Social and Counselling Issues in Hereditary Cancer Susceptibility 381
Biographical Notes 399
Index 405
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