Genetics and Cancer Susceptibility: Implications for Risk Assessement

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Specialists in their respective fields review the impact of both intrinsic genetic factors and extrinsic modifiers on human cancer risk. The book's main thrust is on susceptibility factors that are targets for chemical carcinogens, intrinsic factors that modify cancer risk and biomonitoring and extrinsic risk modification.
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Overview

Specialists in their respective fields review the impact of both intrinsic genetic factors and extrinsic modifiers on human cancer risk. The book's main thrust is on susceptibility factors that are targets for chemical carcinogens, intrinsic factors that modify cancer risk and biomonitoring and extrinsic risk modification.
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Product Details

Table of Contents

Contributors
Preface
Acknowledgments
The Role of p53 Loss in Genomic Instability and Tumor Progression in a Murine Mammary Cancer Model
Genetic Susceptibility to In Vivo and In Vitro Chemical Transformation 13
Tlag 1, a Novel Murine Tumor Susceptibility Gene That Regulates MNU-Induced Thymic Lymphoma Development 23
Genetic Analysis of Multistage Hepatocarcinogenesis 33
Genetic Susceptibility to Tumor Progression in Mouse Skin Carcinogenesis 47
One Decade of Comparative Molecular Carcinogenesis 57
Validation Issues for the Use of Transgenic Mouse Mutation Assays in Risk Assessment 81
Cytochrome P-450 and Acetyltransferase Expression as Biomarkers of Carcinogen-DNA Adduct Levels and Human Cancer Susceptibility 109
Molecular Epidemiology 141
Epidemiology of Susceptibility to Breast Cancer 159
Identifying Genes and Proteins Involved in Human DNA Repair Processes Using Somatic Cell and Molecular Genetics 175
From Host Factors to Genetic Susceptibility 201
Epidemiology of Human Aflatoxin Exposures and Their Relationship to Liver Cancer 211
Diet Intervention for Modifying Cancer Risk 223
Genetic Variation in Susceptibility as a Key Parameter in Risk Assessment and Risk Communication: Policy Aspects 235
Index 249
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