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Genetics and Evolution of Aging / Edition 1

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Overview

The study of aging has recently been transformed by the application of tools and ideas from genetics and evolution. This development began in 1980, and has since been gathering momentum. The present volume collects most of the principles contributing to this new direction in aging research. Additionally the book incorporates elements from both molecular genetics and evolutionary genetics, uniting two divergent strategies in the study of aging. Some of the book's articles are more molecular, and some are more evolutionary in their orientation, some contributions combine both approaches in a way that has rarely been seen. The book will thus be of broad interest through all 'levels' of biology, from molecular biology to evolutionary biology.
The phylogenetic diversity covered by the articles is also fairly great: from yeast to plants, nematodes to Drosophila, and rodents to man. Nonetheless, there is a unity to the treatment, with questions like mutation-accumulation, number of loci, and the possibility of postponing aging arising repeatedly throughout the discussions of particular taxonomic groups.
There are few better starting places for graduate students interested in biological aging research than this volume. It is also a convenient collection for research workers in the area, who may need to track down an important idea or result. Finally, the book as a whole provides a bracing overview of biological aging.

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Product Details

Table of Contents

Preface 1
Pt. 1 General perspectives on aging
The Janiform genetics of aging 5
Evolutionary mechanisms of senescence 13
Mutation-selection balance and the evolution of senescence 22
Pathogen evolution within host individuals as a primary cause of senescence 29
Pt. 2 Diversity of aging
Comparative approaches to the study of senescence: bridging genetics and phylogenetics 45
The genetics of aging in the yeast Saccharomyces cerevisiae 54
Evolutionary senescence in plants 71
Comparing mutants, selective breeding, and transgenics in the dissection of aging processes of Caenorhabditis elegans 83
New model systems for studying the evolutionary biology of aging: crustacea 96
Pt. 3 Aging in Drosophila
Evolution of aging: testing the theory using Drosophila 109
Population density effects on longevity 119
Evolution of delayed reproductive senescence in male fruit flies: sperm competition 130
Genetic and environmental factors regulating the expression of an extended longevity phenotype in a long lived strain of Drosophila 145
The effect of superoxide dismutase alleles on aging in Drosophila 161
Use of recombinant inbred strains to map genes of aging 168
The effects of enhanced expression of elongation factor EF-1[alpha] on lifespan in Drosophila melanogaster IV. A summary of three experiments 183
Two-dimensional protein electrophoretic analysis of postponed aging in Drosophila 199
Pt. 4 Aging in mammals
Longevity and fecundity in eutherian mammals 217
Thoughts on the evolutionary basis of dietary restriction 226
Genetic control of retroviral disease in aging wild mice 232
Genetics of life span in mice 243
Genes of the major histocompatibility complex and the evolutionary genetics of lifespan 256
Genetic influences on glucose neurotoxicity, aging, and diabetes: a possible role for glucose hysteresis 270
Genetic heterogeneity of gene defects responsible for familial Alzheimer disease
Abiotrophic gene action in Homo sapiens: potential mechanisms and significance for the pathobiology of aging 294
Antagonistic pleiotropy, mutation accumulation, and human genetic disease 307
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