Genetics and Tuberculosis / Edition 1

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Overview

Genetics and Tuberculosis Chairman: Douglas Young 1998 More people die each year from tuberculosis than from any other infectious disease, the annual death toll being almost three million (over 95% of which are in developing countries) with eight million new cases being diagnosed every year. It is estimated that one-third of the world's population - nearly two billion people - is now infected, of which 5-10% will develop the disease. In 1993, the World Health Organization recognized tuberculosis as a 'global health emergency', the first time that a disease had ever been marked in this way. The emergence of drug-resistant forms of the disease combined with the paucity of new drugs makes the challenge of understanding and combating the disease especially urgent. This book explores the interplay between the Mycobacterium and its host by focusing on the research currently underway on the sequencing of the genome of Mycobacterium tuberculosis, and on the genetic and epidemiological studies of communities exposed to the disease (and on related animal models). From a synthesis of these data, new insights into the understanding of the pathogenesis, prevention and treatment of tuberculosis emerge.

Disc. epidemiology, immunotherapeutic intervention, susceptibility, resistance.

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Editorial Reviews

Booknews
With the resurgence of TB at the rate of eight million new cases annually and about one-third of the world population already infected, increasing attention is being focused on this once "conquered" disease<-->particularly on the dreaded drug-resistant varieties. The 18 papers of the November 1997 Cape Town symposium present research on the sequencing of the genome in the search for novel drugs and DNA vaccines; genetic and epidemiological studies of communities exposed to the disease (e.g. developing nations, the HIV-infected, and the homeless); host genetic susceptibility and resistance; and animal models. General discussions address endocytic trafficking and the myobacterial vacuole, and the biosynthesis of cell wall molecules. Edited by Derek Chadwick and Gail Cardew. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780471982616
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 1/28/1998
  • Series: Novartis Foundation Symposia Series , #236
  • Edition number: 1
  • Pages: 280
  • Product dimensions: 6.36 (w) x 9.33 (h) x 0.72 (d)

Table of Contents

Introduction 1
Host genetic susceptibility to human tuberculosis 3
The epidemiology of tuberculosis in South Africa 24
Using conventional and molecular epidemiological analyses to target tuberculosis control interventions in a low incidence area 42
Vaccines, genes and trials 57
Immunological and endocrinological characteristics of tuberculosis that provide opportunities for immunotherapeutic intervention 73
Recombinant interleukin 2 adjunctive therapy in multidrug-resistant tuberculosis 99
Cellular and genetic mechanisms underlying susceptibility of animal models to tuberculosis infection 112
Susceptibility to tuberculosis as a complex genetic trait: analysis using recombinant congenic strains of mice 120
Signals that regulate the host response to Mycobacterium tuberculosis 145
Analysis of the genome of Mycobacterium tuberculosis H37Rv 160
Bacterial genetics and strain variation 178
Antibiotic resistance in mycobacteria 195
Mechanisms for isoniazid action and resistance 209
The impact of genomics on the search for novel tuberculosis drugs 228
DNA vaccines against tuberculosis 239
Summary 254
Epilogue 258
Index of contributors 260
Subject index 262
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