Genetics and Tuberculosis / Edition 1by Novartis Foundation, Derek J. Chadwick, Gail Cardew
Pub. Date: 01/28/1998
Genetics and Tuberculosis Chairman: Douglas Young 1998 More people die each year from tuberculosis than from any other infectious disease, the annual death toll being almost three million (over 95% of which are in developing countries) with eight million new cases being diagnosed every year. It is estimated that one-third of the world's population - nearly two billion people - is now infected, of which 5-10% will develop the disease. In 1993, the World Health Organization recognized tuberculosis as a 'global health emergency', the first time that a disease had ever been marked in this way. The emergence of drug-resistant forms of the disease combined with the paucity of new drugs makes the challenge of understanding and combating the disease especially urgent. This book explores the interplay between the Mycobacterium and its host by focusing on the research currently underway on the sequencing of the genome of Mycobacterium tuberculosis, and on the genetic and epidemiological studies of communities exposed to the disease (and on related animal models). From a synthesis of these data, new insights into the understanding of the pathogenesis, prevention and treatment of tuberculosis emerge.
Table of Contents
Host Genetic Susceptibility to Human Tuberculosis (R. Bellamy & A. Hill).
The Epidemiology of Tuberculosis in South Africa (P. Donald).
Using Conventional and Molecular Epidemiological Analyses to Target Tuberculosis Control Interventions in a Low Incidence Area (P. Hopewell).
Vaccines, Genes and Trials (P. Fine).
Immunological and Endocrinological Characteristics of Tuberculosis that Provide Opportunities for Immunotherapeutic Intervention (G. Rook & R. Hernandez-Pando).
Recombinant Interleukin 2 Adjunctive Therapy in Multidrug-Resistant Tuberculosis (B. Johnson, et al.).
Cellular and Genetic Mechanisms Underlying Susceptibility of Animal Models to Tuberculosis Infection (I. Orme).
Susceptibility to Tuberculosis as a Complex Genetic Trait: Analysis Using Recombinant Congenic Strains of Mice (I. Kramnik, et al.).
ENDOCYTIC TRAFFICKING AND THE MYCOBACTERIAL VACUOLE.
Signals that Regulate the Host Response to Mycobacterium tuberculosis (A. Beyers, et al.).
Analysis of the Genome of Mycobacterium tuberculosis H37Rv (S. Cole & B. Barrell).
Bacterial Genetics and Strain Variation (P. van Helden).
Antibiotic Resistance in Mycobacteria (J. Davies).
Mechanisms for Isoniazid Action and Resistance (L. Miesel, et al.).
THE BIOSYNTHESIS OF CELL WALL MOLECULES.
The Impact of Genomics on the Search for Novel Tuberculosis Drugs (K. Duncan).
DNA Vaccines Against Tuberculosis (J. Ulmer, et al.).
Summary (D. Young).
Epilogue (S. Benatar).
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